DRSC/TRiP Functional Genomics Resources

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Protein Alignment Esyt2 and Esyt1

DIOPT Version :9

Sequence 1:NP_001247287.1 Gene:Esyt2 / 42929 FlyBaseID:FBgn0266758 Length:853 Species:Drosophila melanogaster
Sequence 2:NP_058945.2 Gene:Esyt1 / 29579 RGDID:3053 Length:1088 Species:Rattus norvegicus


Alignment Length:1092 Identity:294/1092 - (26%)
Similarity:467/1092 - (42%) Gaps:315/1092 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 PTGNGTPPTQTT---NGNSIVATKSVSDDNSIFSVFYTLGKKVAIVGSIYLVGYMGWSVAWLIAP 106
            |:|. :|.|.:|   :|.|.|........:...:|..:.|:::.::..:||.|..|.||.:::..
  Rat    13 PSGQ-SPATDSTRERDGGSGVPPAGPGAASEALAVLTSFGRRLLVLVPVYLAGAAGLSVGFVLFG 76

  Fly   107 VILSV----ARDQLAKTSEKKRDIAKASALASEKDVILARI-----DELPAWVYFPDVERCEWLN 162
            :.|.:    .||      .|:|.:..|..|..:::.|.|..     .||||||.|||||:.||||
  Rat    77 LALYLGWRRVRD------GKERSLRAARQLLDDEERITAETLYMSHRELPAWVSFPDVEKAEWLN 135

  Fly   163 KILKQVWPNANHFARTLVKETIEPNVALALANYKMHGFRFDRIILGTIPPRIGGVKIYDKNVDRN 227
            ||:.||||....:...|:.||:.|  |:..||..:..|.|.|:.||..|.||.|||::... .::
  Rat   136 KIVVQVWPFLGQYMEKLLAETVAP--AVRGANPHLQTFTFTRVELGEKPVRIIGVKVHPSQ-RKD 197

  Fly   228 EIIMDLDLFYASDCDINF----YLGGMKGGIKDFQIHGWVRVVMKPLIRSMPLVGGLQIFFLNNP 288
            :|::||::.|..|..|:.    |.  .|.|:|..|:||.:||:::|||..:|:||.:.:||:..|
  Rat   198 QILLDLNVSYVGDLQIDVEVKKYF--CKAGVKGMQLHGVLRVILEPLIGDLPIVGAVSMFFIKRP 260

  Fly   289 NIDFNLVGVIDFMDMPGLSDLLRRIIVEQIGNVMVLPNKLPISLSEEVSAVA-LKMPEPEGILRI 352
            .:|.|..|:.:.:|:||||.|...:|::.|...:||||:|.:.|..::..|| |:.|.|.||:||
  Rat   261 TLDINWTGMTNLLDIPGLSSLSDTMIMDSIAAFLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRI 325

  Fly   353 HVVEAKDLMKKDISVLG--KGKSDPYAIINVGAQEFKTQIIDNNVNPKWDYWCEACIFTTIGHYI 415
            |::.|:.|..||..|.|  :|||||||::.||.|.|.:::||..:||:|....|..:....|..|
  Rat   326 HLLAARGLSSKDKYVKGLIEGKSDPYALVRVGTQTFCSRVIDEELNPRWGETYEVIVHEVPGQEI 390

  Fly   416 GFSLWDYDQTMPGVQSDDVLGRASIDIASVIKKGVVDSWLTLEDAKHGLLHVRLQWYKLTADPND 480
            ...::|.|.     ..||.|||..:|:..|::.||:|:|..|:..: |.:|:||:|..|..|...
  Rat   391 EVEVFDKDP-----DKDDFLGRMKLDVGKVLQAGVLDNWYPLQGGQ-GQVHLRLEWLSLLPDAEK 449

  Fly   481 LQQILLETQLLR-VTSM----SSAVLSVFIDSARHLKQARSSSKPDPYLVCSVNKQKQQTAMIMR 540
            |.|:|   |..| :||.    |:|:|.|::|.|:.|...:.:.:|:|.:..||....|::.....
  Rat   450 LDQVL---QWNRGITSRPEPPSAAILVVYLDRAQDLPLKKGNKEPNPMVQLSVQDVTQESKATYS 511

  Fly   541 DDSPVWEQGFTFLVSNPDNESLNIKIYDQKTGNDIGQYTYTLSTLLKQFNMEVIQQPFQLQKSGP 605
            .:.||||:.|.|.:.:|.::.|::::.|......:|..|..|:.||....: .:.|.|||..|||
  Rat   512 TNCPVWEEAFRFFLQDPRSQELDVQVKDDSRALTLGALTLPLARLLTASEL-TLDQWFQLSSSGP 575

  Fly   606 ESKLYMSLSLRIL-----------KPGEIDKDSDA------------------------------ 629
            .|:|||.|.:|||           :||..|.||::                              
  Rat   576 NSRLYMKLVMRILYLDSSEMRLPTEPGAQDWDSESPETGSSVDAPPRPYHTTPNSHFGTENVLRI 640

  Fly   630 ----------------------------------------------------------------- 629
                                                                             
  Rat   641 HVLEAQDLIAKDRFLGGLVKGKSDPYVKLKVAGRSLRTHVVREDLNPRWNEVFEVIVTSIPGQEL 705

  Fly   630 ------------------------------------------------------------LEQV- 633
                                                                        ||:| 
  Rat   706 DIEVFDKDLDKDDFLGRYKVGLTTVLNSGFLDEWLTLEDVPSGRLHLRLERLSPRPTAAELEEVL 770

  Fly   634 ---------------AA-----LTRS----------------------SSVKTPDVAAVSPPAFK 656
                           ||     |.||                      :|.||..|:..|.|.::
  Rat   771 QVNSLIQTQKSSELAAALLSVYLERSEDLPLRKGTKPPSPYAILTVGETSHKTKTVSQTSAPIWE 835

  Fly   657 ES--------QASSKRL-----------SAESPISE---EDPVAATK------------------ 681
            ||        .|.|..|           |...|:||   |:.:...:                  
  Rat   836 ESASFLIRKPHAESLELQVRGEGTGTLGSISLPLSELLQEEQLCLDRWFALSGQGQVLMRVQLGI 900

  Fly   682 -ISP-------AMSASTSSEKP-----ISELATSVL--THRFP--DSTSSPGEHGLGRMQLSIRY 729
             :|.       :.|:|:.:|:|     .:..|:.||  .||..  ||.|......||:::|::.|
  Rat   901 LVSQHSGVEAHSHSSSSLNEEPEVLGDPTHTASPVLEVRHRLTHGDSPSEALIGPLGQVKLTVWY 965

  Fly   730 SAQRQKLDVTIHKIQKIPLRDPSNIPDPYVKLYLLPGRTKESKRKTSVIKDNCNPVYDASFEYLI 794
            .:..|||...||..:.: .::..::|||||.:.|||.:.:.:|||||..|...||.::..||:.:
  Rat   966 HSDEQKLISIIHSCRAL-RQNGRDLPDPYVSVLLLPDKNRGTKRKTSQKKRTLNPEFNERFEWDL 1029

  Fly   795 SIAELRQTELEVTVCTQKGFLSGGSPIIGMLKIPLDDAEITTQTGLNSWFDL 846
            .:....:.:|:|:|.:...|:|....::|  |:.||.|||....|...|:||
  Rat  1030 PLDGTLRRKLDVSVKSNSSFMSRERELLG--KVQLDLAEIDLSQGAAQWYDL 1079

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Esyt2NP_001247287.1 SMP_LBD 154..332 CDD:293652 71/181 (39%)
C2A_Synaptotagmin-like 348..471 CDD:175990 48/124 (39%)
C2B_Synaptotagmin-like 500..605 CDD:176015 29/104 (28%)
C2C_KIAA1228 719..847 CDD:175996 43/128 (34%)
Esyt1NP_058945.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..38 8/25 (32%)
SMP_LBD 127..305 CDD:293652 71/182 (39%)
C2A_C2C_Synaptotagmin_like 321..440 CDD:176037 48/124 (39%)
C2B_Synaptotagmin-like 471..575 CDD:176015 29/104 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 599..630 5/30 (17%)
C2A_C2C_Synaptotagmin_like 637..755 CDD:176037 0/117 (0%)
C2B_Synaptotagmin-like 788..890 CDD:176015 19/101 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 911..930 4/18 (22%)
C2C_KIAA1228 955..1079 CDD:175996 41/126 (33%)
Required for phosphatidylinositol 4,5-bisphosphate-dependent location at the cell membrane. /evidence=ECO:0000250 1002..1009 1/6 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166346273
Domainoid 1 1.000 138 1.000 Domainoid score I4714
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 423 1.000 Inparanoid score I1715
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D196935at33208
OrthoFinder 1 1.000 - - FOG0000510
OrthoInspector 1 1.000 - - otm46424
orthoMCL 1 0.900 - - OOG6_100476
Panther 1 1.100 - - O PTHR45761
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X61
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1211.900

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