DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Esyt2 and Esyt3

DIOPT Version :9

Sequence 1:	NP_001247287.1	Gene:	Esyt2 / 42929	FlyBaseID:	FBgn0266758	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_808443.2	Gene:	Esyt3 / 272636	MGIID:	1098699	Length:	891	Species:	Mus musculus

Alignment Length:	914	Identity:	251/914 - (27%)
Similarity:	427/914 - (46%)	Gaps:	137/914 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 PTTPTGNGTPPTQTTNGNSIVATKSVSDDNSIFSVFYTLGKKVAI-VGSIYLVGYMGWSVAWLIA 105
            |..|:..|.|........|......:|  ..:....|:...:|.. :..:||.||:|.||.||:.
Mouse     6 PCAPSAPGGPDVPERGQRSRDPGPRLS--GQLLPELYSFVARVLFYLAPVYLAGYLGLSVTWLLL 68

  Fly   106 PVILSV--ARDQLAKTSEKKRDIAKASALASEKDVILARI--DELPAWVYFPDVERCEWLNKILK 166
            ..:|.:  .|::..|....:   |....|..|::.|...:  ..||||::||||||.||.|||:.
Mouse    69 GALLWMWWRRNRRGKLGRLE---AAFEFLEHEREFISRELRGQHLPAWIHFPDVERVEWANKIII 130

  Fly   167 QVWPNANHFARTLVKETIEPNVALALANYKMHGFRFDRIILGTIPPRIGGVKIYDKNVDRNEIIM 231
            |:||..:......::|.:||.:  ...:..:..|.|.::..|...|::.|||::....:|.::.:
Mouse   131 QIWPYLSMIMENKIREKLEPKI--REKSIHLRTFTFTKLYFGQKCPKVNGVKVHTDKRNRRKVTL 193

  Fly   232 DLDLFYASDCDINFYLGGMKGGIKDFQIHGWVRVVMKPLIRSMPLVGGLQIFFLNNPNIDFNLVG 296
            ||.:.|..||:|:..|..::||:...|:.|.:||:::||:...|.:|.:.:|||..|::..|..|
Mouse   194 DLQICYIGDCEISVELQKIRGGVSGVQLQGTLRVILEPLLVDKPFIGAVTVFFLQKPHLQINWTG 258

  Fly   297 VIDFMDMPGLSDLLRRIIVEQIGNVMVLPNKLPISLSEEVSAVALKMPEPEGILRIHVVEAKDLM 361
            :.:.:||||:::|...::.:.|...:||||::.:.:.:.:....|::|.|.|::|:|::|||.|.
Mouse   259 LTNLLDMPGINELSDSLLEDLIAAHLVLPNRVTVPVKKGLDVTNLRVPLPCGVIRVHLLEAKKLA 323

  Fly   362 KKDISVLG-KGKSDPYAIINVGAQEFKTQIIDNNVNPKWDYWCEACIFTTIGHYIGFSLWDYDQT 425
            :|| :.|| .|||||||.:::|.|..:::.|..|:||.|:...|..::...|..:...|:|.|
Mouse   324 QKD-NFLGLGGKSDPYAKVSIGLQHCRSRTIYKNLNPTWNEVFEFMVYEVPGQDLEVDLYDED-- 385

  Fly   426 MPGVQSDDVLGRASIDIASVIKKGVVDSWLTLEDAKHGLLHVRLQWYKLTADPNDLQQILLETQL 490
               ...||.||...|.:..|:|..|||.|..|.|...|.||:||:|..|..|    |:.|.|..
Mouse   386 ---TDKDDFLGSLQICLGDVMKNRVVDEWFALNDTTSGRLHLRLEWLSLLTD----QEALTEND- 442

  Fly   491 LRVTSMSSAVLSVFIDSARHLK--------------------QARSSSKPDPYLVCSVNKQKQQT 535
               :.:|:|:|.||:::|.:|.                    :.::|..|..|:..:|.|:...:
Mouse   443 ---SGLSTAILVVFLENACNLPRNPFDYLNGEYRAKKLSRFVKNKASRDPSSYVKLTVGKKTFTS 504

  Fly   536 AMIMRDDSPVWEQGFTFLVSNPDNESLNIKIYDQKTGNDIGQYTYTLSTLLKQFNMEVIQQPFQL 600
            ........|||.|.|:|.|.:...|.|.:|:.|.:....:|...:.|..:|...:: .::|.|||
Mouse   505 KTCPHSKDPVWSQVFSFFVHSVAAEQLCLKVLDDELECALGVLEFPLCRILPCADL-TLEQCFQL 568

  Fly   601 QKSGPESKLYMSLSLRILKP-----GEIDKDSDALEQ----VAALTRSSSVKTP-------DVAA 649
            ..||.:|.:.|.|.||.|:.     |......|||::    :..:..:...|.|       ||.:
Mouse   569 DHSGLDSLISMRLVLRFLRVEGRELGSPYTGPDALKKGPLFIKKVATNQGCKAPPLNEGLADVTS 633

  Fly   650 VSPPA--FKESQASSKRLSA----------------------------ESPISEEDPVAA----- 679
            .|.||  .|.:..|...:||                            |||..:::|...
Mouse   634 TSNPASYIKGASKSIDNISAATTDPEPMPEPQGPGPEPKGKDSARGLCESPGKKKNPATTFLTVP 698

  Fly   680 -------------------------TKISPAMSASTSSEKPISELATSVLTHRFPDSTSSPGEHG 719
                                     |:::|:||:..|......:|....|.....||.    :..
Mouse   699 GLHSPGPIKSPRPMSRPAFPFAWPLTRVAPSMSSLNSLASSCFDLTDVSLNTEAGDSR----QGR 759

  Fly   720 LGRMQLSIRYSAQRQKLDVTIHKIQKI-PLRDPSNIPDPYVKLYLLPGRTKESKRKTSVIKDNCN 783
            ||.:||::||...|..|.|.::..:.: |.  .|:..||||::||||.|...|::||||.:....
Mouse   760 LGEIQLTVRYVCLRHCLRVLVNGCRNLTPC--TSSGADPYVRIYLLPERRWASRKKTSVKQKTLE 822

  Fly   784 PVYDASFEYLISIAELRQTELEVTVCTQKGFLSGGSPIIGMLKIPLDDAEITTQTGLNSWFDL-- 846
            |::|.:||:.:.:.|:::..|:|.|...:...|.....:|.:.|.|...::.  .|.:.|::|
Mouse   823 PLFDETFEFFVPMGEVQKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKQDLI--KGFSQWYELTA 885

  Fly   847 --QP 848
              ||
Mouse   886 DGQP 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esyt2	NP_001247287.1	SMP_LBD	154..332	CDD:293652	56/177 (32%)
		C2A_Synaptotagmin-like	348..471	CDD:175990	48/123 (39%)
		C2B_Synaptotagmin-like	500..605	CDD:176015	29/124 (23%)
		C2C_KIAA1228	719..847	CDD:175996	40/132 (30%)
Esyt3	NP_808443.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		5/23 (22%)
		SMP_LBD	118..294	CDD:293652	56/177 (32%)
		C2A_C2C_Synaptotagmin_like	310..428	CDD:176037	48/123 (39%)
		C2B_Synaptotagmin-like	449..572	CDD:176015	28/123 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	652..711		6/58 (10%)
		C2C_KIAA1228	759..884	CDD:175996	39/128 (30%)
		Required for phosphatidylinositol 4,5-bisphosphate-dependent location at the cell membrane. /evidence=ECO:0000250	806..813		2/6 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842804
Domainoid	1	1.000	157	1.000	Domainoid score	I4148
eggNOG	1	0.900	-	-		E1_COG5038
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	462	1.000	Inparanoid score	I1541
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48596
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000510
OrthoInspector	1	1.000	-	-		otm44327
orthoMCL	1	0.900	-	-		OOG6_100476
Panther	1	1.100	-	-	LDO	PTHR45761
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2311
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790