Protein Alignment Esyt2 and tcb3

DIOPT Version :10

• Sequence 1: NP_001247287.1
• Gene: Esyt2 / 42929
• FlyBaseID: FBgn0266758
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: NP_593974.1
• Gene: tcb3 / 2542267
• PomBaseID: SPAPYUK71.03C
• Length: 1225
• Species: Schizosaccharomyces pombe
• Alignment Length: 622
• Identity: 134/622 - (21%)
• Similarity: 251/622 - (40%)
• Gaps: 127/622 - (20%)

  Fly    76 VFYTLGKKVAIVGSIYLVGYM--GWSVAWLIAPVILSVAR--DQLAKTSEKKRDIAKASALASEK 136
            |.||     |::.  :|.||:  |:...::|..|.:...|  |:..|.:.|.......|....|.
pombe   159 VLYT-----AVMS--FLFGYLRFGFLSLFIIMAVCIQYYRICDRRVKVNFKDDYTRYLSTRKLEN 216

  Fly   137 DVILARIDELPAWVYFPDVERCEWLNKILKQVW----PNANHFARTLVKETIEPNV-----ALAL 192
                             |.|...|||..|:|.|    |:.:.....:..:.:..||     ::||
pombe   217 -----------------DSETVTWLNTFLQQFWYIFEPSLSERITEITDQILSENVPSFIDSMAL 264

  Fly   193 ANYKMHGFRFDRIILGTIPPRIGGVKIYDKNVDRNEIIMDLDLFYASDCDINFYLG--------- 248
            :.:          .|||..||:|.::.|.| .:.:.::|||.|.::.: ||:...|
pombe   265 SEF----------TLGTKSPRMGFIRSYPK-TEEDTVMMDLRLAFSPN-DISDLTGREIAACIKP 317

  Fly   249 ----GMKGG-----------IKDFQIHGWVRVVMKPLIRSMPLVGGLQIFFLNNPNIDFNLVGV- 297
                .:|.|           |:|....|.:||.:| ||...|....:.:.|...|...:.|..:
pombe   318 KIALDLKIGKSIASAKMPVLIEDLSFTGNLRVKVK-LIDKYPYAKTVGLTFTEKPVFSYILKPLG 381

  Fly   298 -----IDFMDMPGLSDLLRRIIVEQIGNVMVLPNKLPISLSEEVSAVALKMPEPEGILRIHVVEA 357
                 .|..::|||:..:...|...:|.:|..||...:.:...:.|..|.       ..:..||.
pombe   382 GDKFGFDIGNIPGLTTFITEQIHNTLGPMMYSPNVYELDIESMMGAAGLN-------TALGAVEF 439

  Fly   358 KDLMKKDISVLGKGKS-DPYAIINVGAQEF--KTQIIDNNVNPKWD---YWCEACIFTTIGHYIG 416
            | |.|.|....|.|.: |||.:|...|...  |:::..|..:|.::   |    .:..:....:.
pombe   440 K-LRKGDGFKDGLGGAVDPYVVIKNSADRVIGKSKVAHNTGSPVFNETFY----SVLNSFSENLN 499

  Fly   417 FSLWDYDQTMPGVQSDDVLGRASIDIASVIKKGVV-DSW--LTLEDAKHGLLHVRLQWYKLTADP 478
            ..::|::.    ::||.:||.|.:.:|::....|. |::  |||:....|.|:..::::.:..|.
pombe   500 LEVYDFND----IRSDKLLGSAVLPLATLEAMPVTNDAFVELTLKGKTVGRLNYDMKFHAVVPDS 560

  Fly   479 NDLQQILLETQLLRVTSMSS-AVLSVFIDSARHLKQARSSSKPDPYLVCSV-NKQKQQTAMIMRD 541
            .:           .:|.:.. .||...:...:.|.. ..|.:|..|....: ||:...|..|.::
pombe   561 GE-----------EITKVDGPGVLQFTVHQCKELSN-DPSKRPTAYAKLIINNKEVYTTRKIKKN 613

  Fly   542 DSPVWEQGFTFLVSNPDNESLNIKIYDQKTGNDIGQYTYTLSTLLKQFNMEVIQQPFQLQKSGPE 606
            ::|.||:.|..|:....|.:|.::|:.:::.:..|....:|..|.......::..|.|   ..|.
pombe   614 NNPSWEESFGTLLPEGKNATLGVQIFTEESEHPFGTANVSLQDLFAATKTGLLWFPLQ---HAPS 675

  Fly   607 SKLYMSLSLRILKPGEIDKDSDALEQVAALTRSSSVK 643
            .::.||:   :.||.:::.||  :..:|..|...:::
pombe   676 GRVRMSV---MWKPAQLNNDS--ISSMALATPIGAIR 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Esyt2	NP_001247287.1	SMP_ESyt	156..332	CDD:439226	50/214 (23%)
		C2A_Synaptotagmin-like	348..471	CDD:175990	31/131 (24%)
		C2B_Synaptotagmin-like	500..605	CDD:176015	23/105 (22%)
		C2C_KIAA1228	719..847	CDD:175996
tcb3	NP_593974.1	COG5038	1..1225	CDD:227371	134/622 (22%)