DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Esyt2 and Pla2g4a

DIOPT Version :9

Sequence 1:	NP_001247287.1	Gene:	Esyt2 / 42929	FlyBaseID:	FBgn0266758	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_598235.2	Gene:	Pla2g4a / 24653	RGDID:	67366	Length:	752	Species:	Rattus norvegicus

Alignment Length:	412	Identity:	89/412 - (21%)
Similarity:	149/412 - (36%)	Gaps:	105/412 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   477 DPNDLQQILLETQ--------LLRVTSMSSAVLSVFIDSARHLKQARSSSKPDPYL---VCSVNK 530
            ||  .|.|::|.|        :||.|.::.......:|:            ||||:   :.:...
  Rat     5 DP--YQHIIVEHQYSHKFTVVVLRATKVTKGTFGDMLDT------------PDPYVELFISTTPD 55

  Fly   531 QKQQTAMIMRDDSPVWEQGFTFLVSNPDNES-LNIKIYDQKTGND--IGQYTYTLSTLLKQFNME 592
            .:::|.....|.:|||.:.|.|:: :|:.|: |.|.:.|.....|  :|..|:.:|::......|
  Rat    56 SRKRTRHFNNDINPVWNETFEFIL-DPNQENVLEITLMDANYVMDETLGTATFPVSSMKVGEKKE 119

  Fly   593 VIQQPFQLQKSGPESKLYMSLSLRILKPGEIDKDSDAL---EQVAALTRSSSVKTPDVAAVSPPA 654
            |   ||...:   .:::.:.:||.:....:: :.|.||   |:.....|..::|......:.|
  Rat   120 V---PFIFNQ---VTEMILEMSLEVCSCPDL-RFSMALCDQEKTFRQQRKENIKENMKKLLGP-- 175

  Fly   655 FKESQASSKRLSAESPISEED-PVAA-----------TKISPAMSASTSSEKPISELATSVLTHR 707
             |:|         |...|..| ||.|           ...|..|.|  ..|..|.:.||.|.
  Rat   176 -KKS---------EGLYSTRDVPVVAILGSGGGFRAMVGFSGVMKA--LYESGILDCATYVA--- 225

  Fly   708 FPDSTSSPGEHGLGRMQLSIRYSAQRQKLDVTIHKIQKIPLRDPSNIPDPYVK-------LYLLP 765
                       ||..   |..|.:       |::.....|.:.|..|.:..:|       |.|.|
  Rat   226 -----------GLSG---STWYMS-------TLYSHPDFPEKGPEEINEELMKNVSHNPLLLLTP 269

  Fly   766 GRTKESKRKTSVIKDNCNPV-YDASFEYLISIAELRQTELEVTVCTQKGFLSGGS---PIIGMLK 826
            .:.|.........|.:..|| :...|..||. ..|.|..:..|:.:.|..:|...   |:...|.
  Rat   270 QKVKRYVESLWKKKSSGQPVTFTDIFGMLIG-ETLIQNRMSTTLSSLKEKVSAARCPLPLFTCLH 333

  Fly   827 IPLDDAEITTQTGLNSWFDLQP 848
            :..|.:|:.    ...|.:..|
  Rat   334 VKPDVSELM----FADWVEFSP 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esyt2	NP_001247287.1	SMP_LBD	154..332	CDD:293652
		C2A_Synaptotagmin-like	348..471	CDD:175990
		C2B_Synaptotagmin-like	500..605	CDD:176015	25/110 (23%)
		C2C_KIAA1228	719..847	CDD:175996	29/138 (21%)
Pla2g4a	NP_598235.2	Phospholipid binding. /evidence=ECO:0000305	1..178		44/197 (22%)
		C2_cPLA2	20..138	CDD:176001	30/136 (22%)
		cPLA2_Grp-IVA	144..730	CDD:132839	53/252 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	427..457
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810