DRSC/TRiP Functional Genomics Resources

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Protein Alignment Esyt2 and Esyt1

DIOPT Version :10

Sequence 1:NP_001247287.1 Gene:Esyt2 / 42929 FlyBaseID:FBgn0266758 Length:853 Species:Drosophila melanogaster
Sequence 2:NP_035973.1 Gene:Esyt1 / 23943 MGIID:1344426 Length:1092 Species:Mus musculus


Alignment Length:1114 Identity:294/1114 - (26%)
Similarity:461/1114 - (41%) Gaps:326/1114 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 MNESPVVTPTTPTGNGTPPT--QTTNGNSIVATKSVSDDNSIFSVFYTLGKKVAIVGSIYLVGYM 96
            |..|| ....:|..:|.||.  .|.:|.|.|........:...:|..:.|:::.::..:||.|..
Mouse     1 MEHSP-EEGASPEPSGQPPATDSTRDGGSGVPPAGPGAASEALAVLTSFGRRLLVLVPVYLAGAA 64

  Fly    97 GWSVAWLIAPVILSV----ARDQLAKTSEKKRDIAKASALASEKDVILARI-----DELPAWVYF 152
            |.||.:::..:.|.:    .||      .|:|.:..|..|..:::.|.|..     .||||||.|
Mouse    65 GLSVGFVLFGLALYLGWRRVRD------GKERSLRAARQLLDDEERITAETLYMSHRELPAWVSF 123

  Fly   153 PDVERCEWLNKILKQVWPNANHFARTLVKETIEPNVALALANYKMHGFRFDRIILGTIPPRIGGV 217
            ||||:.||||||:.||||....:...|:.||:.|  |:..||..:..|.|.|:.||..|.||.||
Mouse   124 PDVEKAEWLNKIVAQVWPFLGQYMEKLLAETVAP--AVRGANPHLQTFTFTRVELGEKPLRIIGV 186

  Fly   218 KIYDKNVDRNEIIMDLDLFYASDCDINF----YLGGMKGGIKDFQIHGWVRVVMKPLIRSMPLVG 278
            |::... .:::|::||::.|..|..|:.    |.  .|.|:|..|:||.:||:::||...:|:||
Mouse   187 KVHPSQ-RKDQILLDLNVSYVGDVQIDVEVKKYF--CKAGVKGMQLHGVLRVILEPLTGDLPIVG 248

  Fly   279 GLQIFFLNNPNIDFNLVGVIDFMDMPGLSDLLRRIIVEQIGNVMVLPNKLPISLSEEVSAVA-LK 342
            .:.:||:..|.:|.|..|:.:.:|:||||.|...:|::.|...:||||:|.:.|..::..|| |:
Mouse   249 AVSMFFIKRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSIAAFLVLPNRLLVPLVPDLQDVAQLR 313

  Fly   343 MPEPEGILRIHVVEAKDLMKKDISVLG--KGKSDPYAIINVGAQEFKTQIIDNNVNPKWDYWCEA 405
            .|.|.||:|||::.|:.|..||..|.|  :|||||||::.||.|.|.:::||..:||.|....|.
Mouse   314 SPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRVGTQTFCSRVIDEELNPHWGETYEV 378

  Fly   406 CIFTTIGHYIGFSLWDYDQTMPGVQSDDVLGRASIDIASVIKKGVVDSWLTLEDAKHGLLHVRLQ 470
            .:....|..|...::|.|.     ..||.|||..:|:..|::.||:|:|..|:..: |.:|:||:
Mouse   379 IVHEVPGQEIEVEVFDKDP-----DKDDFLGRMKLDVGKVLQAGVLDNWYPLQGGQ-GQVHLRLE 437

  Fly   471 WYKLTADPNDLQQILLETQLLR-VTSM----SSAVLSVFIDSARHLKQARSSSKPDPYLVCSVNK 530
            |..|..|...|.|:|   |..| :||.    |:|:|.|::|.|:.|...:.:.:|:|.:..||..
Mouse   438 WLSLLPDAEKLDQVL---QWNRGITSRPEPPSAAILVVYLDRAQDLPLKKGNKEPNPMVQLSVQD 499

  Fly   531 QKQQTAMIMRDDSPVWEQGFTFLVSNPDNESLNIKIYDQKTGNDIGQYTYTLSTLLKQFNMEVIQ 595
            ..:::......:|||||:.|.|.:.:|.::.|::::.|......:|..|..|:.||....: .:.
Mouse   500 VTRESKATYSTNSPVWEEAFRFFLQDPRSQELDVQVKDDSRALTLGALTLPLARLLTASEL-TLD 563

  Fly   596 QPFQLQKSGPESKLYMSLSLRIL-----------KPGEIDKDSDALE------------------ 631
            |.|||..|||.|:|||.|.:|||           .||..|.|.::||                  
Mouse   564 QWFQLSSSGPNSRLYMKLVMRILYLDYSEIRFPTVPGAQDWDRESLETGSSVDAPPRPYHTTPNS 628

  Fly   632 ----------------------------------------------------------------- 631
                                                                             
Mouse   629 HFGTENVLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKVAGKSFRTHVVREDLNPRWNEVFEV 693

  Fly   632 ----------------------------------------------------------------- 631
                                                                             
Mouse   694 IVTSIPGQELEIEVFDKDLDKDDFLGRYKVSLTTVLNSGFLDEWLTLEDVPSGRLHLRLERLTPR 758

  Fly   632 ----------QVAALTRS----------------------------------------SSVKTPD 646
                      ||.:|.::                                        :|.||..
Mouse   759 PTAAELEEVLQVNSLIQTQKSSELAAALLSVFLERAEDLPLRKGTKPPSPYATITVGETSHKTKT 823

  Fly   647 VAAVSPPAFKES--------QASSKRL-----------SAESPISE---EDP------------- 676
            |:..|.|.::||        .|.|..|           |...|:||   ||.             
Mouse   824 VSQSSAPVWEESASFLIRKPHAESLELQVRGEGTGTLGSVSLPLSELLQEDQLCLDHWFALSGQG 888

  Fly   677 -----------------VAATKISPAMSASTSS--------------EKPISELATSVLTHRFPD 710
                             |.|...|.:.|.|:||              ..|:.|:... |||  .|
Mouse   889 QVLMRAQLGILVSQHSGVEAHSHSYSHSHSSSSLNDEPEALGGPTHPASPVLEVRHR-LTH--GD 950

  Fly   711 STSSPGEHGLGRMQLSIRYSAQRQKLDVTIHKIQKIPLRDPSNIPDPYVKLYLLPGRTKESKRKT 775
            |.|......||:::|::.|.:..|||...||..:.: .::..::|||||.:.|||.:.:.:||||
Mouse   951 SPSEAPVGPLGQVKLTVWYHSDEQKLISIIHSCRAL-RQNGRDLPDPYVSVLLLPDKNRSTKRKT 1014

  Fly   776 SVIKDNCNPVYDASFEYLISIAELRQTELEVTVCTQKGFLSGGSPIIGMLKIPLDDAEITTQTGL 840
            ...|...||.::..||:.:.:....:.:|:|:|.:...|:|....::|  |:.||.|||....|.
Mouse  1015 PQKKRTLNPEFNERFEWDLPLDGTLRRKLDVSVKSNSSFMSRERELLG--KVQLDLAEIDLSQGA 1077

  Fly   841 NSWFDLQPE 849
            ..|:||..:
Mouse  1078 AQWYDLMDD 1086

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Esyt2NP_001247287.1 SMP_ESyt 156..332 CDD:439226 68/179 (38%)
C2A_Synaptotagmin-like 348..471 CDD:175990 48/124 (39%)
C2B_Synaptotagmin-like 500..605 CDD:176015 29/104 (28%)
C2C_KIAA1228 719..847 CDD:175996 41/127 (32%)
Esyt1NP_035973.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36 11/35 (31%)
SMP_SF 127..302 CDD:459248 68/179 (38%)
C2A_C2C_Synaptotagmin_like 319..438 CDD:176037 48/124 (39%)
C2B_Synaptotagmin-like 469..573 CDD:176015 29/104 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 604..628 3/23 (13%)
C2A_C2C_Synaptotagmin_like 635..753 CDD:176037 0/117 (0%)
C2B_Synaptotagmin-like 786..888 CDD:176015 17/101 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 909..937 5/27 (19%)
C2C_KIAA1228 959..1084 CDD:175996 41/127 (32%)
Required for phosphatidylinositol 4,5-bisphosphate-dependent location at the cell membrane. /evidence=ECO:0000250|UniProtKB:A0FGR8 1006..1013 1/6 (17%)

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