DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Esyt2 and ESYT1

DIOPT Version :9

Sequence 1:	NP_001247287.1	Gene:	Esyt2 / 42929	FlyBaseID:	FBgn0266758	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_001171725.1	Gene:	ESYT1 / 23344	HGNCID:	29534	Length:	1114	Species:	Homo sapiens

Alignment Length:	1148	Identity:	293/1148 - (25%)
Similarity:	468/1148 - (40%)	Gaps:	358/1148 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SPSVPLAEFTIPPDPTETEPFVPLVEVKKMNESPVVTPTTPTGNGTPPTQTTNGNSIVATKSVSD 69
            ||| |:.:.:.|.|||:..|        ..:..|     .|...|.|......|.::
Human    10 SPS-PMDQPSAPSDPTDQPP--------AAHAKP-----DPGSGGQPAGPGAAGEAL-------- 52

  Fly    70 DNSIFSVFYTLGKKVAIVGSIYLVGYMGWSVAWLIAPVILSV----ARDQLAKTSEKKRDIAKAS 130
                 :|..:.|:::.::..:||.|.:|.||.:::..:.|.:    .||      ||:|.:..|.
Human    53 -----AVLTSFGRRLLVLIPVYLAGAVGLSVGFVLFGLALYLGWRRVRD------EKERSLRAAR 106

  Fly   131 ALASEKDVILARI-----DELPAWVYFPDVERCEWLNKILKQVWPNANHFARTLVKETIEPNVAL 190
            .|..:::.:.|:.     .||||||.|||||:.||||||:.||||....:...|:.||:.|  |:
Human   107 QLLDDEEQLTAKTLYMSHRELPAWVSFPDVEKAEWLNKIVAQVWPFLGQYMEKLLAETVAP--AV 169

  Fly   191 ALANYKMHGFRFDRIILGTIPPRIGGVKIYDKNVDRNEIIMDLDLFYASDCDINF----YLGGMK 251
            ..:|..:..|.|.|:.||..|.||.|||:: ....:.:|::||::.|..|..|:.    |.  .|
Human   170 RGSNPHLQTFTFTRVELGEKPLRIIGVKVH-PGQRKEQILLDLNISYVGDVQIDVEVKKYF--CK 231

  Fly   252 GGIKDFQIHGWVRVVMKPLIRSMPLVGGLQIFFLNNPNIDFNLVGVIDFMDMPGLSDLLRRIIVE 316
            .|:|..|:||.:||:::|||..:|.||.:.:||:..|.:|.|..|:.:.:|:||||.|...:|::
Human   232 AGVKGMQLHGVLRVILEPLIGDLPFVGAVSMFFIRRPTLDINWTGMTNLLDIPGLSSLSDTMIMD 296

  Fly   317 QIGNVMVLPNKLPISLSEEVSAVA-LKMPEPEGILRIHVVEAKDLMKKDISVLG--KGKSDPYAI 378
            .|...:||||:|.:.|..::..|| |:.|.|.||:|||::.|:.|..||..|.|  :|||||||:
Human   297 SIAAFLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYAL 361

  Fly   379 INVGAQEFKTQIIDNNVNPKWDYWCEACIFTTIGHYIGFSLWDYDQTMPGVQSDDVLGRASIDIA 443
            :.:|.|.|.:::||..:||:|....|..:....|..|...::|.|.     ..||.|||..:|:.
Human   362 VRLGTQTFCSRVIDEELNPQWGETYEVMVHEVPGQEIEVEVFDKDP-----DKDDFLGRMKLDVG 421

  Fly   444 SVIKKGVVDSWLTLEDAKHGLLHVRLQWYKLTADPNDLQQILLETQLL--RVTSMSSAVLSVFID 506
            .|::..|:|.|..|:..: |.:|:||:|..|.:|...|:|:|.....:  |....|:|:|.|::|
Human   422 KVLQASVLDDWFPLQGGQ-GQVHLRLEWLSLLSDAEKLEQVLQWNWGVSSRPDPPSAAILVVYLD 485

  Fly   507 SARHLKQARS----------SSKPDPYLVCSVNKQKQQTAMIMRDDSPVWEQGFTFLVSNPDNES 561
            .|:.|....|          :.:|:|.:..|:....|::..:...:.||||:.|.|.:.:|.::.
Human   486 RAQDLPMVTSELYPPQLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQE 550

  Fly   562 LNIKIYDQKTGNDIGQYTYTLSTLLKQFNMEVIQQPFQLQKSGPESKLYMSLSLRIL-------- 618
            |::::.|......:|..|..|:.||....: ::.|.|||..|||.|:|||.|.:|||
Human   551 LDVQVKDDSRALTLGALTLPLARLLTAPEL-ILDQWFQLSSSGPNSRLYMKLVMRILYLDSSEIC 614

  Fly   619 ----------------------------------------------------------------- 618

Human   615 FPTVPGCPGAWDVDSENPQRGSSVDAPPRPCHTTPDSQFGTEHVLRIHVLEAQDLIAKDRFLGGL 679

  Fly   619 -----------------------------------------KPGE------IDKDSD-------- 628
                                                     .||:      .|||.|
Human   680 VKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVIVTSVPGQELEVEVFDKDLDKDDFLGRC 744

  Fly   629 -----------------------------------------ALEQV------------------- 633
                                                     .||:|
Human   745 KVRLTTVLNSGFLDEWLTLEDVPSGRLHLRLERLTPRPTAAELEEVLQVNSLIQTQKSAELAAAL 809

  Fly   634 -----------------------AALT-RSSSVKTPDVAAVSPPAFKES--------QASSKRL- 665
                                   |.|| ..||.||..::..|.|.:.||        ...|..|
Human   810 LSIYMERAEDLPLRKGTKHLSPYATLTVGDSSHKTKTISQTSAPVWDESASFLIRKPHTESLELQ 874

  Fly   666 ----------SAESPISE----------------------------------EDPVAATKISPAM 686
                      |...|:||                                  ...|.|...|.:.
Human   875 VRGEGTGVLGSLSLPLSELLVADQLCLDRWFTLSSGQGQVLLRAQLGILVSQHSGVEAHSHSYSH 939

  Fly   687 SASTSSEKP--------ISELATSV---LTHRFPDSTSSPGEHGLGRMQLSIRYSAQRQKLDVTI 740
            |:|:.||:|        |:..|..:   |||  .||........||:::|::.|.::.:||...:
Human   940 SSSSLSEEPELSGGPPHITSSAPELRQRLTH--VDSPLEAPAGPLGQVKLTLWYYSEERKLVSIV 1002

  Fly   741 HKIQKIPL--RDPSNIPDPYVKLYLLPGRTKESKRKTSVIKDNCNPVYDASFEYLISIAELRQTE 803
            |..:.:..  |||   |||||.|.|||.:.:.:||:||..|...:|.::..||:.:.:.|.::.:
Human  1003 HGCRSLRQNGRDP---PDPYVSLLLLPDKNRGTKRRTSQKKRTLSPEFNERFEWELPLDEAQRRK 1064

  Fly   804 LEVTVCTQKGFLSGGSPIIGMLKIPLDDAEITTQTGLNSWFDL 846
            |:|:|.:...|:|....::|  |:.||.||.....|:..|:||
Human  1065 LDVSVKSNSSFMSRERELLG--KVQLDLAETDLSQGVARWYDL 1105

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esyt2	NP_001247287.1	SMP_LBD	154..332	CDD:293652	70/181 (39%)
		C2A_Synaptotagmin-like	348..471	CDD:175990	46/124 (37%)
		C2B_Synaptotagmin-like	500..605	CDD:176015	29/114 (25%)
		C2C_KIAA1228	719..847	CDD:175996	43/130 (33%)
ESYT1	NP_001171725.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48		13/51 (25%)
		SMP_LBD	135..313	CDD:293652	70/182 (38%)
		C2A_C2C_Synaptotagmin_like	329..448	CDD:176037	46/124 (37%)
		C2B_Synaptotagmin-like	479..593	CDD:176015	29/114 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	627..651		0/23 (0%)
		C2A_C2C_Synaptotagmin_like	657..776	CDD:176037	6/118 (5%)
		C2B_Synaptotagmin-like	809..910	CDD:176015	17/100 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	934..960		7/25 (28%)
		C2C_KIAA1228	981..1106	CDD:175996	43/130 (33%)
		Required for phosphatidylinositol 4,5-bisphosphate-dependent location at the cell membrane. /evidence=ECO:0000250	1028..1035		1/6 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	157	1.000	Domainoid score	I4142
eggNOG	1	0.900	-	-		E1_COG5038
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	463	1.000	Inparanoid score	I1556
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D196935at33208
OrthoFinder	1	1.000	-	-		FOG0000510
OrthoInspector	1	1.000	-	-		otm42273
orthoMCL	1	0.900	-	-		OOG6_100476
Panther	1	1.100	-	-	O	PTHR45761
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2311
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860