DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Esyt2 and esyt-2

DIOPT Version :9

Sequence 1:	NP_001247287.1	Gene:	Esyt2 / 42929	FlyBaseID:	FBgn0266758	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_001366808.1	Gene:	esyt-2 / 175882	WormBaseID:	WBGene00020443	Length:	808	Species:	Caenorhabditis elegans

Alignment Length:	821	Identity:	259/821 - (31%)
Similarity:	422/821 - (51%)	Gaps:	77/821 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 VAIVGS------IYLVGYMGWSVAWLIAPVILSVARDQLAKTSEKKRDIAKASALASEKDVILAR 142
            |.:|||      .:.:|...:|..|::..:|.||.:..|.:..|::....:|:|| .|::||:|:
Worm     8 VPLVGSAILSTFTFFLGKWDYSFVWVLIIIIASVTKSYLWRKRERRLIALRATAL-REREVIMAQ 71

  Fly   143 IDELPAWVYFPDVERCEWLNKILKQVWPNANHFARTLVKETIEPNVALALANYKMHGFRFDRIIL 207
            :.:|||||.|||.||.|||||::.|:||....:.:|.:.:.|.|.|...:.. ....|:|.::.:
Worm    72 LQDLPAWVQFPDTERVEWLNKVIHQLWPYVGEYTKTFMNDFIIPQVKAQMPG-MFKNFKFTKMDM 135

  Fly   208 GTIPPRIGGVKIYDKNVDRNEIIMDLDLFYASDCDINFYLGGMKGGIKDFQIHGWVRVVMKPLIR 272
            |.||.|:||:|:|..||.|:.||:|:|:.||.|.|......|..||:.:.|..|.:|.::|||:.
Worm   136 GDIPCRVGGIKVYTTNVGRDRIIVDMDVAYAGDADFTVSCCGFTGGMNNIQFSGKLRAILKPLLP 200

  Fly   273 SMPLVGGLQIFFLNNPNIDFNLVGVIDFMDMPGLSDLLRRIIVEQIGNVMVLPNKLPISLSEEVS 337
            ..|:|||:...||..|.:||||.|:.:.:::|||.|.:|.:|..||..:.||||::.:.|:.:|.
Worm   201 YPPMVGGVSGTFLEMPKMDFNLTGMGEMVELPGLIDAIRSVINSQIAALCVLPNEIVVPLAPDVD 265

  Fly   338 AVALKMPEPEGILRIHVVEAKDLMKKDISVLGKGKSDPYAIINVGAQEFKTQIIDNNVNPKWDYW 402
            ...|..|||:|::|:.::|||:|..:|||.:.||||||||.|.||:|.|||:.||:::||.|:.:
Worm   266 VTQLYFPEPDGVVRLKIIEAKNLENRDISFIKKGKSDPYAEIQVGSQFFKTRTIDDDLNPIWNEY 330

  Fly   403 CEACIFTTIGHYIGFSLWDYDQTMPGVQSDDVLGRASIDIASVIKKGVVDSWLTLEDAKHGLLHV 467
            .||.:....|..:...|:|.||     ..|:.|||.|:|:..|..||.:|.|..||..|||.||:
Worm   331 FEAVVDQADGQKLRIELFDEDQ-----GKDEELGRLSVDLKLVQAKGTIDKWYPLEGCKHGDLHI 390

  Fly   468 RLQWYKLTADPNDLQQILLETQLLRVTS-MSSAVLSVFIDSARHLKQARSSSKPDPYLVCSVNKQ 531
            :..|..|:.:...|::...|.:..:... :.||:|.|:|||...|...:|..:|.|::..|:.|:
Worm   391 KATWMNLSTELRHLEKQEWEAEWGQADKPIHSALLMVYIDSVADLPYPKSKLEPSPFVEVSLGKE 455

  Fly   532 KQQTAMIMRDDSPVWEQGFTFLVSNPDNESLNIKIYDQKTGNDIGQYTYTLSTLLKQFNMEVIQQ 596
            .|:|.:.::..:|:::..|.|.|.:.:.:.|..:..|..|...:|.....|:||||:.|:|..||
Worm   456 TQRTPVKVKTVNPLFQSKFLFFVRHLEGQELKFEAVDDGTRRSLGSLNIPLTTLLKEPNLEQNQQ 520

  Fly   597 PFQLQKSGPESKLYMSLSLRILKPGEID----------KDSDALEQVAAL-----TRSSSVKTPD 646
            ...|.....:|.:.::..:|:|:..|.|          |:.:.|...|.:     ..::|....|
Worm   521 MHMLTLGVHQSPIVITTRIRVLQKTEGDAIKMQELRQEKEEEKLRNNALIQGKPKKGNNSELGHD 585

  Fly   647 VAAVSPPAFKESQASSKRLSAESPISEEDPVAATKISPAMSASTSSEKPISELATSVLTHRF--P 709
            |......||...:|:.|        ...|.||   :.||.:.:..:.....|:..:|..::.  .
Worm   586 VLGEYGNAFHIERANGK--------VNGDVVA---VEPAKTVNQDAADDEVEIKLNVDNYQMLRS 639

  Fly   710 DSTSSPGEHG-----LGRM--------QLSIRYSAQRQKLDVTIH--------KIQKIPLRDPSN 753
            ||..|...||     |||:        :...|....|.::::.|.        ||..|..||...
Worm   640 DSQGSLNSHGRSNSRLGRLFRSKHEMKKRETRADENRGEIEIQIDFDDLVNQLKIALIRCRDLMT 704

  Fly   754 IP-----DPY--VKLYLLPGRTKESKRKTSVIKDNCNPVYDASFEYLISIAELRQTELEVTV--C 809
            ..     :||  |||..|.|..:..|:||...|:..:|.:|...|..|:.::|...::.:.|  .
Worm   705 FDKKDQCNPYVSVKLVALDGNKEVFKKKTPTAKNTRHPHFDNHVEIDINPSDLLNHKVVINVKDD 769

  Fly   810 TQKG-FLSGGSPIIGMLKIPLDDAEITTQTGLNSWFDLQPE 849
            |..| |::  .|::|.|:|.||  .:..:.....|..|..|
Worm   770 TNYGTFVA--KPVLGCLEIRLD--SLMNRQLSQRWIPLSVE 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esyt2	NP_001247287.1	SMP_LBD	154..332	CDD:293652	69/177 (39%)
		C2A_Synaptotagmin-like	348..471	CDD:175990	54/122 (44%)
		C2B_Synaptotagmin-like	500..605	CDD:176015	31/104 (30%)
		C2C_KIAA1228	719..847	CDD:175996	39/158 (25%)
esyt-2	NP_001366808.1	SMP_LBD	83..260	CDD:293652	69/177 (39%)
		C2A_C2C_Synaptotagmin_like	276..394	CDD:176037	54/122 (44%)
		C2B_Synaptotagmin-like	424..528	CDD:176015	31/103 (30%)
		C2	691..800	CDD:214577	31/112 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159137
Domainoid	1	1.000	150	1.000	Domainoid score	I2702
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32699
Inparanoid	1	1.050	389	1.000	Inparanoid score	I1145
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48596
OrthoDB	1	1.010	-	-		D196935at33208
OrthoFinder	1	1.000	-	-		FOG0000510
OrthoInspector	1	1.000	-	-		oto18936
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45761
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.010