DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Esyt2 and LOC100493446

DIOPT Version :9

Sequence 1:	NP_001247287.1	Gene:	Esyt2 / 42929	FlyBaseID:	FBgn0266758	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_017948766.2	Gene:	LOC100493446 / 100493446	-ID:	-	Length:	588	Species:	Xenopus tropicalis

Alignment Length:	547	Identity:	160/547 - (29%)
Similarity:	276/547 - (50%)	Gaps:	30/547 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 KKVAIVGSIYLVGYMGWSVAWLIAPVILSVARDQLAKTSEKKRDIAKASALASEKDVILARIDEL 146
            |.|.|:...|.:|.:.:.:.::|  :||.|.:..:...|.::....|...:..||       .:.
Frog    18 KYVLILVLSYFLGCLQFKIGYVI--LILLVLKCYMLWRSRRRPTEKKTEEIPKEK-------KKA 73

  Fly   147 PAWVYFPDVERCEWLNKILKQVWPNANHFARTLVKETIEPNVALALANYKMHGFRFDRIILGTIP 211
            |..|.....||.:.||.|.:.:||....:..|::::.|:|.:. :.:.| :...||..|..|..|
Frog    74 PGRVPGEHFERSKSLNAIFENIWPYLTEYLETMLRQKIQPKIR-SSSKY-LASLRFINIDFGDKP 136

  Fly   212 PRIGGVKIYDKNVDRNEIIMDLDLFYASD--CDINFYLGGMKGGIKDFQIHGWVRVVMKPLIRSM 274
            |.:..::.:. :.:|.:||:||::.|.::  .||.|.......|:|..::.|.:|:::.||:...
Frog   137 PEVTALRAHG-DPERKQIILDLEISYDTEVKIDIGFNEKTPIAGVKSIKLEGTLRIILAPLMEDA 200

  Fly   275 PLVGGLQIFFLNNPNIDFNLVGVIDFMDMPGLSDLLRRIIVEQIGNVMVLPNKLPISLSEEVSAV 339
            ||.|.:..:|...|.:|...:|:...:::|||..:..:.||.:|...||.|......:..:....
Frog   201 PLFGAITFYFPQRPVLDLRWIGLTHLLNIPGLHTMSDKKIVNKIAKFMVAPQHFSQRIKAKFDLN 265

  Fly   340 ALKMPEPEGILRIHVVEAKDLMKKDISVLGKGKSDPYAIINVGAQEFKTQIIDNNVNPKWDYWCE 404
            .|...||..:|||||:|||:|..||:|     .||||.:|:.|....:|::|..::||:|:...|
Frog   266 ELHFKEPRIVLRIHVIEAKNLRAKDLS-----SSDPYVVIHGGGTTVQTKVIQKDLNPQWNETFE 325

  Fly   405 ACIFTTIGHYIGFSLWDYDQTMPGVQSDDVLGRASIDIASVIKKGVVDSWLTLEDAKHGLLHVRL 469
            .......|..:.|:|::.|:.:   ..|..||...|.||.|.::..:|.|:.||:|:.|.||::|
Frog   326 ILYTDLPGQEVEFNLFNKDKEL---AKDQPLGSCKIRIADVPERMYLDKWIQLENAESGQLHIKL 387

  Fly   470 QWYKLTADPNDLQQILLE---TQLLRVTSMSSAVLSVFIDSARHLKQAR-SSSKPDPYLVCSVNK 530
            :..:|.:||..|:::|.|   ||..|.|.||||||..||:.||.|...: ...|.:|..|..|..
Frog   388 ERLQLLSDPTKLEEVLKENEQTQTERRTQMSSAVLYTFIEKARGLPVVQVQKGKLNPLAVVQVAV 452

  Fly   531 QK--QQTAMIMRDDSPVWEQGFTFLVSNPDNESLNIKIYDQKTGNDIGQYTYTLSTLLKQFNMEV 593
            |.  |:|...:::....|::.|.||:.||..|.|.:.::|::. ..:|.....||.|:...:| .
Frog   453 QDSVQETGSKVKNGEVEWKRRFQFLLRNPLTEELKLMLHDERQ-KPLGCVAVPLSQLVDAADM-T 515

  Fly   594 IQQPFQLQKSGPESKLYMSLSLRILKP 620
            |:....|:.:.....:.:.|.||||.|
Frog   516 IEDWLPLESTEENRDIRVKLQLRILAP 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esyt2	NP_001247287.1	SMP_LBD	154..332	CDD:293652	48/179 (27%)
		C2A_Synaptotagmin-like	348..471	CDD:175990	44/122 (36%)
		C2B_Synaptotagmin-like	500..605	CDD:176015	30/107 (28%)
		C2C_KIAA1228	719..847	CDD:175996
LOC100493446	XP_017948766.2	SMP_LBD	83..255	CDD:293652	48/174 (28%)
		C2	275..388	CDD:417471	43/120 (36%)
		C2	421..526	CDD:417471	30/106 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D196935at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010