Protein Alignment Cftr and ABCC12

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_150229.2
• Gene: ABCC12 / 94160
• HGNCID: 14640
• Length: 1359
• Species: Homo sapiens
• Alignment Length: 1468
• Identity: 475/1468 - (32%)
• Similarity: 742/1468 - (50%)
• Gaps: 240/1468 - (16%)

  Fly     2 DSSAK---PTR------KNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLG 57
            |.|.|   |.|      .||...|.::|...|:|..|::.:|.|:.|..|.|......|.|:...
Human    26 DPSLKTMIPVRPCARLAPNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNA 90

  Fly    58 DRLEDQWFKELERSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQK 122
            .|....|.:|:.|                  :||.                 .|.|:.::.:||:
Human    91 KRFRVLWDEEVAR------------------VGPE-----------------KASLSHVVWKFQR 120

  Fly   123 TPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPV 187
            |.|  |.:|..|.:.|               :..|:                   ||:
Human   121 TRV--LMDIVANILCI---------------IMAAI-------------------GPV------- 142

  Fly   188 EEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVL-----STLFCCFLLHHVDLRQRLMGARMRIA 247
                   ..:..||.||..........:|..:.|     :.:|...|...::.|..:   |:::|
Human   143 -------ILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAWAINYRTAI---RLKVA 197

  Fly   248 CCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQA-----MLTC--Y 305
            ..:|::...  :|.||......|.::|:||:|...|....:|      .||.|     |:.|  |
Human   198 LSTLVFENL--VSFKTLTHISVGEVLNILSSDSYSLFEAALF------CPLPATIPILMVFCAAY 254

  Fly   306 LIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAW 370
            ..:: :|..|::| :.:.:..:|||..::|:.|..|......||.||..|||.:..|::||||||
Human   255 AFFI-LGPTALIG-ISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAW 317

  Fly   371 EKPFQAVVAEARRSEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAAS 435
            ||.|...:.:.||.|.|.:..|.:::....:.........:.:||:...|:.:.:||...||..:
Human   318 EKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIA 382

  Fly   436 YYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFLM------------------------LEGREE 476
            .:|:::...|| .|.::...|||.|||||::..|:                        |....|
Human   383 MFNVMKFSIAI-LPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLTWEHE 446

  Fly   477 RTQGLTHKRDQEGGDSRAVTIKDINASWDIEKP---------------QKTLQSINLQIEKGQLC 526
            .::..|.|:.|  ...|.:..|..:.::....|               :..|.||:..:.||::.
Human   447 ASRKSTPKKLQ--NQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSVLHSISFVVRKGKIL 509

  Fly   527 AVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQE 591
            .:.|.||:||||:|..|||::.:..|.|.:.|.|:|.:|:.|:|.|:||.||||||::|.:|||.
Human   510 GICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQH 574

  Fly   592 VTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGR 656
            ..|.|.|..|...||.||.|.:||||.:||||||.|||||||||...|:||:||||||||||||:
Human   575 TVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGK 639

  Fly   657 HLFDEVIGP--RGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARL 719
            |:|:|.|..  ||:      |.:|||||:.||...|.:::::.|.|..:||::||:.....:|:|
Human   640 HVFEECIKKTLRGK------TVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKL 698

  Fly   720 LE--RPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSLDSTQL 782
            :.  |..:.::.|:..|.....:.....::.|:...|..:..|.::...:.|.. ||:.:|:
Human   699 IHNLRGLQFKDPEHLYNAAMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESET-GSEFVDT--- 759

  Fly   783 DDNVDEDDL--AEAQASGGISPRVWYEYFHA-GSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQ 844
              .|.|..|  .|:...|.::.:.::.|..| |..|||. |.||:.::.....:.|:::..:|..
Human   760 --KVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSL-FTVFLFLLMIGSAAFSNWWLGLWLD 821

  Fly   845 QEHQRS---QGEATFSTFECM----------YIYGALIIAVVIMTTFRGFLFFKICMHASKVLHD 896
            :..:.:   ||..|......:          ::|.|.::.:::....:||:|.|..:.||..|||
Human   822 KGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHD 886

  Fly   897 RMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVL 961
            .:|..||.:.|.||||||:||::|||||||..:|..||....:|:|   ..|.::.::.||..|.
Human   887 TVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQ---QFFMVVFILVILAAVF 948

  Fly   962 VAAMLVVAVVDV---LILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQD----- 1018
            .|.:||||.:.|   ::|:::.|..|:||::|.:.|||.|:|:::|:.||.||.:...::
Human   949 PAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKESCITY 1013

  Fly  1019 ------VVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYSGNVG 1077
                  ...:.|.|..||..::...|:|:               |.:::||.|.:|      :.|
Human  1014 HLLYFNCALRWFALRMDVLMNILTFTVAL---------------LVTLSFSSISTS------SKG 1057

  Fly  1078 LAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTEL---EQEPALGEKTPPQQWPTRGQVEF 1139
            |:::..:.|:|::|..||...|:..:.||||.:.:|...   |....|...|.|:.||:||::.|
Human  1058 LSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVGTCPKDWPSRGEITF 1122

  Fly  1140 RNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-IEGEIFIDGIETGT 1203
            |:...||..|...||.:|||.|::|..||||||||:|||||..|||||.. ..|.||||.::...
Human  1123 RDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICI 1187

  Fly  1204 ISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAI----PGLDYMVTE 1264
            :|||.|||::::||||||||..|:||||||||.:||..||..||...:|..|    ..|...|||
Human  1188 LSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTE 1252

  Fly  1265 RGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHT 1329
            .|.|||||:|||||:|||:|||:|:::||||||::|.:||.|:|.||:..||.|||||:||||:|
Human  1253 NGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNT 1317

  Fly  1330 VMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEA 1367
            |::.|.::||:.|..:|||.|.:|.:|.......::.|
Human  1318 VLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFAMLLAA 1355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	467/1436 (33%)
ABCC12	NP_150229.2	MRP_assoc_pro	43..1344	CDD:188098	468/1438 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	446..491		7/46 (15%)