DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and ABCC12

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_001380726.1	Gene:	ABCC12 / 94160	HGNCID:	14640	Length:	1359	Species:	Homo sapiens

Alignment Length:	1468	Identity:	475/1468 - (32%)
Similarity:	741/1468 - (50%)	Gaps:	240/1468 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DSSAK---PTR------KNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLG 57
            |.|.|   |.|      .||...|.::|...|:|..|::.:|.|:.|..|.|......|.|:...
Human    26 DPSLKTMIPVRPCARLAPNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNA 90

  Fly    58 DRLEDQWFKELERSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQK 122
            .|....|.:|:.|                  :||.                 .|.|:.::.:||:
Human    91 KRFRVLWDEEVAR------------------VGPE-----------------KASLSHVVWKFQR 120

  Fly   123 TPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPV 187
            |.|  |.:|..|.:.|               :..|:                   ||
Human   121 TRV--LMDIVANILCI---------------IMAAI-------------------GP-------- 141

  Fly   188 EEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVL-----STLFCCFLLHHVDLRQRLMGARMRIA 247
                  ...:..||.||..........:|..:.|     :.:|...|...::.|..:   |:::|
Human   142 ------TVLIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAWAINYRTAI---RLKVA 197

  Fly   248 CCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQA-----MLTC--Y 305
            ..:|::...  :|.||......|.::|:||:|...|....:|      .||.|     |:.|  |
Human   198 LSTLVFENL--VSFKTLTHISVGEVLNILSSDSYSLFEAALF------CPLPATIPILMVFCAAY 254

  Fly   306 LIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAW 370
            ..:: :|..|::| :.:.:..:|||..::|:.|..|......||.||..|||.:..|::||||||
Human   255 AFFI-LGPTALIG-ISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAW 317

  Fly   371 EKPFQAVVAEARRSEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAAS 435
            ||.|...:.:.||.|.|.:..|.:::....:.........:.:||:...|:.:.:||...||..:
Human   318 EKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIA 382

  Fly   436 YYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFLM------------------------LEGREE 476
            .:|:::...|| .|.::...|||.|||||::..|:                        |....|
Human   383 MFNVMKFSIAI-LPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLTWEHE 446

  Fly   477 RTQGLTHKRDQEGGDSRAVTIKDINASWDIEKP---------------QKTLQSINLQIEKGQLC 526
            .::..|.|:.|  ...|.:..|..:.::....|               :..|.||:..:.||::.
Human   447 ASRKSTPKKLQ--NQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSVLHSISFVVRKGKIL 509

  Fly   527 AVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQE 591
            .:.|.||:||||:|..|||::.:..|.|.:.|.|:|.:|:.|:|.|:||.||||||::|.:|||.
Human   510 GICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQH 574

  Fly   592 VTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGR 656
            ..|.|.|..|...||.||.|.:||||.:||||||.|||||||||...|:||:||||||||||||:
Human   575 TVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGK 639

  Fly   657 HLFDEVIGP--RGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARL 719
            |:|:|.|..  ||:      |.:|||||:.||...|.:::::.|.|..:||::||:.....:|:|
Human   640 HVFEECIKKTLRGK------TVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKL 698

  Fly   720 LE--RPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSLDSTQL 782
            :.  |..:.::.|:..|.....:.....::.|:...|..:..|.::...:.|.. ||:.:|:
Human   699 IHNLRGLQFKDPEHLYNAAMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESET-GSEFVDT--- 759

  Fly   783 DDNVDEDDL--AEAQASGGISPRVWYEYFHA-GSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQ 844
              .|.|..|  .|:...|.::.:.::.|..| |..|||. |.||:.::.....:.|:::..:|..
Human   760 --KVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSL-FTVFLFLLMIGSAAFSNWWLGLWLD 821

  Fly   845 QEHQRS---QGEATFSTFECM----------YIYGALIIAVVIMTTFRGFLFFKICMHASKVLHD 896
            :..:.:   ||..|......:          ::|.|.::.:::....:||:|.|..:.||..|||
Human   822 KGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHD 886

  Fly   897 RMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVL 961
            .:|..||.:.|.||||||:||::|||||||..:|..||....:|:|   ..|.::.::.||..|.
Human   887 TVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQ---QFFMVVFILVILAAVF 948

  Fly   962 VAAMLVVAVVDV---LILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQD----- 1018
            .|.:||||.:.|   ::|:::.|..|:||::|.:.|||.|:|:::|:.||.||.:...::
Human   949 PAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKESCITY 1013

  Fly  1019 ------VVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYSGNVG 1077
                  ...:.|.|..||..::...|:|:               |.:::||.|.:|      :.|
Human  1014 HLLYFNCALRWFALRMDVLMNILTFTVAL---------------LVTLSFSSISTS------SKG 1057

  Fly  1078 LAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTEL---EQEPALGEKTPPQQWPTRGQVEF 1139
            |:::..:.|:|::|..||...|:..:.||||.:.:|...   |....|...|.|:.||:||::.|
Human  1058 LSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVGTCPKDWPSRGEITF 1122

  Fly  1140 RNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-IEGEIFIDGIETGT 1203
            |:...||..|...||.:|||.|::|..||||||||:|||||..|||||.. ..|.||||.::...
Human  1123 RDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICI 1187

  Fly  1204 ISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAI----PGLDYMVTE 1264
            :|||.|||::::||||||||..|:||||||||.:||..||..||...:|..|    ..|...|||
Human  1188 LSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTE 1252

  Fly  1265 RGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHT 1329
            .|.|||||:|||||:|||:|||:|:::||||||::|.:||.|:|.||:..||.|||||:||||:|
Human  1253 NGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNT 1317

  Fly  1330 VMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEA 1367
            |::.|.::||:.|..:|||.|.:|.:|.......::.|
Human  1318 VLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFAMLLAA 1355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	470/1456 (32%)
		ABC_membrane	214..441	CDD:294371	63/238 (26%)
		ABCC_MRP_domain1	495..699	CDD:213217	97/220 (44%)
		ABC_membrane	863..1088	CDD:294371	75/238 (32%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	122/219 (56%)
ABCC12	NP_001380726.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..491		7/46 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.730