DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and ABCC10

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	XP_016866934.1	Gene:	ABCC10 / 89845	HGNCID:	52	Length:	1558	Species:	Homo sapiens

Alignment Length:	1431	Identity:	438/1431 - (30%)
Similarity:	702/1431 - (49%)	Gaps:	236/1431 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ISQLIFAWAIPLLYRGSRRGLNTDDLTQ----CLKEDRSEQLGDRLEDQWFKELERSHRKKQKPH 79
            :|:..:||..|||.||:     ..:|.|    |       :|..||:..:...:.::| .::...
Human   272 LSRFSYAWLAPLLARGA-----CGELRQPQDIC-------RLPHRLQPTYLARVFQAH-WQEGAR 323

  Fly    80 LRNALF----RCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISISD 140
            |..||:    ||:|.    .||:..:..::....|.:|: ||:.|
Human   324 LWRALYGAFGRCYLA----LGLLKLVGTMLGFSGPLLLS-LLVGF-------------------- 363

  Fly   141 SLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQTV 205
                                                   ||..|.|   :.|.......:....|
Human   364 ---------------------------------------LEEGQEP---LSHGLLYALGLAGGAV 386

  Fly   206 EHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKTAGQTPAG 270
                     |||||...   ..:.::.|.|:.|  ||.:.|     :|.|.|:|.   ..:.|.|
Human   387 ---------LGAVLQNQ---YGYEVYKVTLQAR--GAVLNI-----LYCKALQLG---PSRPPTG 429

  Fly   271 YLINLLSNDVNR-LDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTALS 334
            ..:|||..|..| |::...| |..|.:|||..:|.||::..:|: |.||.:.|.|..|||...::
Human   430 EALNLLGTDSERLLNFAGSF-HEAWGLPLQLAITLYLLYQQVGV-AFVGGLILALLLVPVNKVIA 492

  Fly   335 KVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRG-- 397
            .........:.:..||||.::.||:.||:|||...||:...|.|...|..|:.::|...||..
Human   493 TRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAAC 557

  Fly   398 FYL-STMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVS 461
            .|| :.:.......::||.   .|||..:||..||:|.:...:| ::....:|..::...||.||
Human   558 VYLWAALPVVISIVIFITY---VLMGHQLTATKVFTALALVRML-ILPLNNFPWVINGLLEAKVS 618

  Fly   462 LRRIQDFLMLEGREERTQ--------GLTHK----RDQEGGDSRAVTIKDINASWD-IEKPQKTL 513
            |.|||.||.|.....:..        |...|    .|.....|..:.:.....||| :....:|.
Human   619 LDRIQLFLDLPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGALFSWDPVGTSLETF 683

  Fly   514 QSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQG---DLSYAAQEPWLFTGSVR 575
            .| :|:::||.|..::|.||.||||:|..:.|||..:.|.|.::|   ....|.||||:...::|
Human   684 IS-HLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFATIR 747

  Fly   576 NNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQI 640
            :|||||:.||.:.|:||...|||:.|...||.||:|.|||:|.:|||||||||:||||||:..::
Human   748 DNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKEL 812

  Fly   641 YLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLK-ATRILVTHQVHFLSEADVIVIVDQGRILRQG 704
            ||:||||:||||.|..||....|     |..|. .||:|.||:..:|..||.:::::.||::|.|
Human   813 YLLDDPLAAVDADVANHLLHRCI-----LGMLSYTTRLLCTHRTEYLERADAVLLMEAGRLIRAG 872

  Fly   705 TYQELINSDLDFARLLER-PKE-EEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQ 767
            ...|::       .|::. ||. .|.|:.|.:.|:    .|:::.::       .|:|.::  :|
Human   873 PPSEIL-------PLVQAVPKAWAENGQESDSATA----QSVQNPEK-------TKEGLEE--EQ 917

  Fly   768 SSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVC 832
            |:|   .:.|..             |::..|.::..|:..|:.|....|:.: ::|.:::.|...
Human   918 STS---GRLLQE-------------ESKKEGAVALHVYQAYWKAVGQGLALA-ILFSLLLMQATR 965

  Fly   833 SSSDFFANIW--------TQQEHQRSQGEATFSTFE---CMYIYGALIIAVV------------- 873
            :::|::.:.|        :.||.|.|...|:...|.   .::..|.|.|.|.
Human   966 NAADWWLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDI 1030

  Fly   874 ---------------IMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFS 923
                           :.|..|..||....:.|:..||.|:...:|.|.:.||:.||:||||||||
Human  1031 RFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFS 1095

  Fly   924 KDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKR 988
            .|:...|:.||..:...:..|..:.|:|.|:|...|.|:..:..::::...:.:.|...|::|:|
Human  1096 SDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRR 1160

  Fly   989 LEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVS 1053
            |..:..||::|||:.:|.||:::|:........:|...|.:::......|.|....|.:.|..:.
Human  1161 LGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLDIRLQLMG 1225

  Fly  1054 CIFLTSVTFSFIISSETTYS--GNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYT-E 1115
            ...::::....::..:...:  |.|||:::.|:.|||::...|....::...:.||||:.:|| :
Human  1226 AAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCD 1290

  Fly  1116 LEQEPALGEKTPPQQ----WPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAG 1176
            |.|||    :..|.|    |.|:|.|||:::...|.|.....|..:...::.|.|:|||||||:|
Human  1291 LPQEP----QGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSG 1351

  Fly  1177 KSSLIGALFRLAH-IEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDA 1240
            ||||:..||||.. ..|.:.:||::|..:.|..||::::||||:|.|||.|:|.||||...:.|.
Human  1352 KSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDR 1416

  Fly  1241 ELWSALEDVELRKAIP---GLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQ 1302
            .||.||:...|.:.|.   |||..:.|.|.:.|:|||||||||||:|.:.|:|.:|||||:||.:
Human  1417 ALWQALKQCHLSEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQK 1481

  Fly  1303 TDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEA 1367
            ||.|:|:||..:|...||||:||||:|:::|||::|:.||..||.|.|..|..:.....:|::::
Human  1482 TDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQS 1546

  Fly  1368 T 1368
            :
Human  1547 S 1547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	438/1428 (31%)
		ABC_membrane	214..441	CDD:294371	73/230 (32%)
		ABCC_MRP_domain1	495..699	CDD:213217	91/208 (44%)
		ABC_membrane	863..1088	CDD:294371	63/254 (25%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	105/218 (48%)
ABCC10	XP_016866934.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720