Protein Alignment Cftr and ABCC3

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_003777.2
• Gene: ABCC3 / 8714
• HGNCID: 54
• Length: 1527
• Species: Homo sapiens
• Alignment Length: 1434
• Identity: 466/1434 - (32%)
• Similarity: 740/1434 - (51%)
• Gaps: 203/1434 - (14%)

  Fly     4 SAKPTRKN--PRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFK 66
            |||....|  |...|..:|:|.|.|...:...|.|..|...||....:||||:.:..:|.:.|.|
Human   198 SAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRK 262

  Fly    67 ELERSHRKK-----------------------QKPHLRNALFRCFLGPTIINGLICFIYIVIKTL 108
            :.:::.|.|                       :||....||...|....:|:.....|..::..:
Human   263 QEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFI 327

  Fly   109 IPAVLAQLLIQFQKTPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKS 173
            .|.:|: :||:|...|:|                       |::
Human   328 NPQLLS-ILIRFISNPMA-----------------------PSW--------------------- 347

  Fly   174 LDKAGPLEPIQPPVEEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQR 238
                                               |       ..||...:|.|.::..:.|:..
Human   348 -----------------------------------W-------GFLVAGLMFLCSMMQSLILQHY 370

  Fly   239 -----LMGARMRIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPL 298
                 :.|.:.|.....:||||.|.::......:..|.::||:|.|..|......|::.:|..||
Human   371 YHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPL 435

  Fly   299 QAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQ 363
            |.:|..|.:|.|:| |:::..|..::..:|:..|::......:::..:..|:|:.:|:|::.||:
Human   436 QIILAIYFLWQNLG-PSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIK 499

  Fly   364 VIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRGFYLSTMVFTER-STLYITLAAAALM-----G 422
            |:|:||||..|...|...|:.|::.:|.|:||.    :|..||.. |...:||....:.     .
Human   500 VLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLH----TTTTFTWMCSPFLVTLITLWVYVYVDPN 560

  Fly   423 QTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQ 487
            ..:.|:..|.:.|.:|||:|...: .|..:|...:|.|||:|||.||..|  |...|.:..|...
Human   561 NVLDAEKAFVSVSLFNILRLPLNM-LPQLISNLTQASVSLKRIQQFLSQE--ELDPQSVERKTIS 622

  Fly   488 EGGDSRAVTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDG 552
            .|   .|:||.....:|..:.| .||.|:::|:.||.|.||:||||.||||::..||||:..::|
Human   623 PG---YAITIHSGTFTWAQDLP-PTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEG 683

  Fly   553 GVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERG 617
            .|.::|.::|..|:.|:...:::.|:|||:..:.||||:....|||..|.:.||.||:|.:||:|
Human   684 KVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKG 748

  Fly   618 ASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQ 682
            .:||||||.|:|||||||..|.|:|:||||||||:||.:|:||.||||.|.||  ..||:||||.
Human   749 INLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLA--GKTRVLVTHG 811

  Fly   683 VHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLL-ERPKEEEEG---------ENSRNQTS 737
            :.||.:.|.|:::..|::...|.|..|:..:..||..| ....:|::|         |.:.::.:
Human   812 ISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEA 876

  Fly   738 PLSVNSLE-----SDDEDIPFIDGVKDGYQQLRKQSSSVHG-SKSLDSTQLDDNVDEDDLAEAQA 796
            .|..::|.     :|::.:.:: ..|...:||...||...| .:.:....|..: ::..:.||:|
Human   877 LLIEDTLSNHTDLTDNDPVTYV-VQKQFMRQLSALSSDGEGQGRPVPRRHLGPS-EKVQVTEAKA 939

  Fly   797 SGGISPR-----------VWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQQEHQRS 850
            .|.::..           |:::|  |.:..|..:..:.::.:.|   |::...||:|.......:
Human   940 DGALTQEEKAAIGTVELSVFWDY--AKAVGLCTTLAICLLYVGQ---SAAAIGANVWLSAWTNDA 999

  Fly   851 QGEA-TFSTFECMYIYGALIIAVVIMTTFRGFLFFKICM-------HASKVLHDRMFACILHATM 907
            ..:: ..:|...:.:|.||.|       .:|||.....|       .|::|||..:....:.:..
Human  1000 MADSRQNNTSLRLGVYAALGI-------LQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQ 1057

  Fly   908 RFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVD 972
            .||||||||||||.||||:..:||:|...::..:.........|:||....|:....:|.:||:.
Human  1058 SFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLY 1122

  Fly   973 VLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQL 1037
            .|:.:.|...|:.|||||.:.|||::||.|.::||.::||:...    :::|:::.|......|.
Human  1123 TLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNR----SRDFEIISDTKVDANQR 1183

  Fly  1038 T----MAVNTTLGLWLDCV-SCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQV 1097
            :    :..|..|.:.::.| :|:.|.:..|: :|...:...|.|||:::.::.:|..:.:.:|.:
Human  1184 SCYPYIISNRWLSIGVEFVGNCVVLFAALFA-VIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMM 1247

  Fly  1098 AESLQQMTSVERVLQYTELEQE-PALGE-KTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLT 1160
            ::....:.:||||.:|::.|.| |.:.| ..||:.||.||:|||||.|.||.|....|||:|:|.
Human  1248 SDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLH 1312

  Fly  1161 IEAGWKVGIVGRTGAGKSSLIGALFR-LAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFS 1224
            :..|.||||||||||||||:...||| |...:|||.|||:....|.|..||::::||||||:|||
Human  1313 VHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFS 1377

  Fly  1225 ATIRYNLDPFERYTDAELWSALEDVELRKAI----PGLDYMVTERGGNFSVGQRQLLCLARAILR 1285
            .|:|.|||||..|::.::|.|||...|...:    .|||:..:|.|.|.|||||||:|||||:||
Human  1378 GTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLR 1442

  Fly  1286 NNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVP 1350
            .:::||||||||.:|.:||.|||.|||.:|..|||||:||||:|:||..|::|:|.||..|||.|
Human  1443 KSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSP 1507

  Fly  1351 YLLL 1354
            ..|:
Human  1508 ANLI 1511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	462/1424 (32%)
ABCC3	NP_003777.2	MRP_assoc_pro	7..1526	CDD:188098	466/1434 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	910..932		4/22 (18%)