Protein Alignment Cftr and VMR1

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_011828.1
• Gene: VMR1 / 856350
• SGDID: S000001027
• Length: 1592
• Species: Saccharomyces cerevisiae
• Alignment Length: 1508
• Identity: 431/1508 - (28%)
• Similarity: 709/1508 - (47%)
• Gaps: 298/1508 - (19%)

  Fly     2 DSSAKPTRKNPRQH-ANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWF 65
            |....|:    |:| ::|:|.:.::|....::...:..:...|:.....||.|..:        .
Yeast   261 DDHTSPS----REHISSILSCITWSWITNFIWEAQKNTIKLKDIWGLSMEDYSIFI--------L 313

  Fly    66 KELERSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRN 130
            |...|  |.|...:|..|||..|....:| |::..:...|..|:|.:|.:..::
Yeast   314 KGFTR--RNKHINNLTLALFESFKTYLLI-GMLWVLVNSIVNLLPTILMKRFLE----------- 364

  Fly   131 IDVNDISISDSLNRTARAIPN----YV-------LSQAVANSSGSPGDALFPKSLDKAGPLEPIQ 184
                   |.|:.||::..: |    |:       |:.|:.||.|.
Yeast   365 -------IVDNPNRSSSCM-NLAWLYIIGMFICRLTLAICNSQGQ-------------------- 401

  Fly   185 PPVEEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACC 249
                                               .:|...|               .|:|....
Yeast   402 -----------------------------------FVSDKIC---------------LRIRAILI 416

  Fly   250 SLIYRKTLRLSMKTAGQTPA---------GYLINLLSND---VNRL-DYGFIFMHWIWIMPLQAM 301
            ..||.|.||..:.|:.:|.:         |.:|||:|.|   |:.| :|.::.:..:    :..:
Yeast   417 GEIYAKGLRRRLFTSPKTSSDSDSISANLGTIINLISIDSFKVSELANYLYVTVQAV----IMII 477

  Fly   302 LTCYLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIK 366
            :...|::..:|:.|..| :.::|...|:...|:.:....:.:..:.||.|:..:||.:|.|:::|
Yeast   478 VVVGLLFNFLGVSAFAG-ISIILVMFPLNFLLANLLGKFQKQTLKCTDQRISKLNECLQNIRIVK 541

  Fly   367 MYAWEKPFQAVVAEARRSEIKQIRYASYLRGFYLSTMVFTERSTLY---------ITLAAAA-LM 421
            .:|||:..        .:|||.||... ||.....::|::..|.|:         :|.|... :.
Yeast   542 YFAWERNI--------INEIKSIRQKE-LRSLLKKSLVWSVTSFLWFVTPTLVTGVTFAICTFVQ 597

  Fly   422 GQTITADFVFSAASYYNILQLVAAIWYPL-----AVSFGAEALVSLRRIQDFLMLEGREERTQGL 481
            .:.:.|...|:..|.:.:|:.      ||     .:||..::.|||:||.|||.::..|:..| |
Yeast   598 HEDLNAPLAFTTLSLFTLLKT------PLDQLSNMLSFINQSKVSLKRISDFLRMDDTEKYNQ-L 655

  Fly   482 THKRDQEGGDSRAVTIKDINASW---DIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLL 543
            |...|:     ..:..|:...:|   |.:.....|..:|::.:.|:|..::|..|:|||::|..|
Yeast   656 TISPDK-----NKIEFKNATLTWNENDSDMNAFKLCGLNIKFQIGKLNLILGSTGSGKSALLLGL 715

  Fly   544 LGELPVIDGGVFI-----QGDL-----------SYAAQEPWLFTGSVRNNILFGEEFDRKRYQEV 592
            ||||.:|.|.:.:     :.||           :|.:|..||...:|:|||:|...::..||.:|
Yeast   716 LGELNLISGSIIVPSLEPKHDLIPDCEGLTNSFAYCSQSAWLLNDTVKNNIIFDNFYNEDRYNKV 780

  Fly   593 TRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRH 657
            ...|.|..|.:.||.||.|.:||:|.:|||||:.|||||||||..|:..|:||.|||||:|....
Yeast   781 IDACGLKRDLEILPAGDLTEIGEKGITLSGGQKQRISLARAVYSSAKHVLLDDCLSAVDSHTAVW 845

  Fly   658 LFDEVI-GPRGRLAQLKATRILVTHQVHF-LSEADVIVIVDQGRILRQGTYQELINSDLDFARLL 720
            :::..| ||    .....|.|||||.|.. |..|...::::.|::..|||..||.:..|.
Yeast   846 IYENCITGP----LMKNRTCILVTHNVSLTLRNAHFAIVLENGKVKNQGTITELQSKGLF----- 901

  Fly   721 ERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSLDSTQLDDN 785
               ||:....:||:..:..:.|.|::..         |:..|::...:.::    :.|:..::|.
Yeast   902 ---KEKYVQLSSRDSINEKNANRLKAPR---------KNDSQKIEPVTENI----NFDANFVNDG 950

  Fly   786 --VDEDDLAEAQASGGISPRV--WYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQQE 846
              ::|    |.:::|.|||.|  ||..|..|...|:..|.::  :.:|::..|..::...|....
Yeast   951 QLIEE----EEKSNGAISPDVYKWYLKFFGGFKALTALFALY--ITAQILFISQSWWIRHWVNDT 1009

  Fly   847 HQR-----------------SQGEATFSTFECMYIYGALIIAVVIMTTFRGFLFFKICMHASKVL 894
            :.|                 ...:...:.|..:.:|..:.|...::..|:..:.|...|.||:.:
Yeast  1010 NVRINAPGFAMDTLPLKGMTDSSKNKHNAFYYLTVYFLIGIIQAMLGGFKTMMTFLSGMRASRKI 1074

  Fly   895 HDRMFACILHATMRFFDTTPSGRILNRFSKDMGAID-ELLPR---AMMDFIQIALVMFGILIVIG 955
            .:.:...:|||.:||||.||.|||:||||||:..:| ||:|.   .:...||.|.::|    :|.
Yeast  1075 FNNLLDLVLHAQIRFFDVTPVGRIMNRFSKDIEGVDQELIPYLEVTIFCLIQCASIIF----LIT 1135

  Fly   956 ILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRS----RQL 1016
            ::.|..:...::|.|:...:.|.||..|::||||:.|.:||:|.|.|.:|.|:..||:    |:.
Yeast  1136 VITPRFLTVAVIVFVLYFFVGKWYLTASRELKRLDSITKSPIFQHFSETLVGVCTIRAFGDERRF 1200

  Fly  1017 QDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLW----LDCVSCIFLTSVTFSFIISSETTY-SGNV 1076
               :.:..:.:...:.:.:.|::.|.     |    :|.:.. |:...:.|||:.:.... ||..
Yeast  1201 ---ILENMNKIDQNNRAFFYLSVTVK-----WFSFRVDMIGA-FIVLASGSFILLNIANIDSGLA 1256

  Fly  1077 GLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQEPALGEK-------TPPQQWPTR 1134
            |:::..|::.|....:.||..:.....|.||||:.:|:.:|||..||..       ..| .||..
Yeast  1257 GISLTYAILFTDGALWLVRLYSTFEMNMNSVERLKEYSSIEQENYLGHDEGRILLLNEP-SWPKD 1320

  Fly  1135 GQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-IEGEIFIDG 1198
            |::|..|:|.||.||..||:||::..::...|:|||||||||||::|.|||||.. |.|.|.|||
Yeast  1321 GEIEIENLSLRYAPNLPPVIRNVSFKVDPQSKIGIVGRTGAGKSTIITALFRLLEPITGCIKIDG 1385

  Fly  1199 IETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVEL------------ 1251
            .:...|.|..||..|:||||||:||:.||:.|:||::.|.:.:::.||..|.|
Yeast  1386 QDISKIDLVTLRRSITIIPQDPILFAGTIKSNVDPYDEYDEKKIFKALSQVNLISSHEFEEVLNS 1450

  Fly  1252 -------RKAIPGLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQR 1309
                   ......|...:.|.|.|.|.|:||||.:||::||..|:::|||||:::|..:|.|||.
Yeast  1451 EERFNSTHNKFLNLHTEIAEGGLNLSQGERQLLFIARSLLREPKIILLDEATSSIDYDSDHLIQG 1515

  Fly  1310 TIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEATGGESEA 1374
            .||.:|.:.|:||:||||.:|:|.|||||||||...|:|.|..|||..:|....|...:|| .|.
Yeast  1516 IIRSEFNKSTILTIAHRLRSVIDYDRIIVMDAGEVKEYDRPSELLKDERGIFYSMCRDSGG-LEL 1579

  Fly  1375 LKKTASDSHKRMQ 1387
            ||:.|..|.|.|:
Yeast  1580 LKQIAKQSSKMMK 1592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	417/1465 (28%)
VMR1	NP_011828.1	MRP_assoc_pro	212..1575	CDD:188098	422/1488 (28%)