DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5789 and YKR104W

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_013030.1	Gene:	YKR104W / 853979	SGDID:	S000001812	Length:	306	Species:	Saccharomyces cerevisiae

Alignment Length:	308	Identity:	134/308 - (43%)
Similarity:	186/308 - (60%)	Gaps:	28/308 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly  1104 MTSVERVLQYTELEQEPALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVG 1168
            |:||||:.:||::..| :.|..:||..||..|.||.:|:|.||.|:.|..|.|::..::||.|||
Yeast     1 MSSVERIKEYTDIPSE-SNGYISPPANWPQTGDVELKNLSLRYSPHSSKALDNVSFKVKAGTKVG 64

  Fly  1169 IVGRTGAGKSSLIGALFRLAHIE-GEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLD 1232
            |||||||||||:|.|::||:..| |.|.||..:...|.||.||..||.|||||.||..|:|.|||
Yeast    65 IVGRTGAGKSSIIAAIYRLSDWENGTITIDNKDIKHIPLERLRNSISCIPQDPTLFDGTVRSNLD 129

  Fly  1233 PFERYTDAELWSALEDV-----------------------ELRKAIPGLDYMVTERGGNFSVGQR 1274
            ||:||:|.:::..|..|                       :||.....|:.:|...|.|.|.|||
Yeast   130 PFDRYSDVQIYGVLSKVGLIEECDELCLIFEQEQPNFSSHKLRNRFIDLNTVVKSGGSNLSQGQR 194

  Fly  1275 QLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVM 1339
            |||||||::|....::::|||||::|..:||.||:|||...|..|:||:||||.:|:|.|:|:||
Yeast   195 QLLCLARSMLGARNIMLIDEATASIDYISDAKIQKTIRETMKNTTILTIAHRLRSVIDYDKILVM 259

  Fly  1340 DAGVAVEFDVPYLLLKKSQGHLRQMVEATGGESEALKKTA--SDSHKR 1385
            :.|...|:|.||.|:........::...: ||.|.|.:.|  |..:||
Yeast   260 EMGRVKEYDHPYTLISDRNTIFYRLCRQS-GEFENLFELAKVSFDNKR 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	126/286 (44%)
		ABC_membrane	214..441	CDD:294371
		ABCC_MRP_domain1	495..699	CDD:213217
		ABC_membrane	863..1088	CDD:294371
		ABCC_MRP_domain2	1135..1350	CDD:213211	110/238 (46%)
YKR104W	NP_013030.1	ABCC_NFT1	27..270	CDD:213269	112/242 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810