DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and NFT1

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_013029.3	Gene:	NFT1 / 853978	SGDID:	S000001811	Length:	1218	Species:	Saccharomyces cerevisiae

Alignment Length:	1113	Identity:	260/1113 - (23%)
Similarity:	483/1113 - (43%)	Gaps:	225/1113 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 LEDQWFKELERSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTP 124
            :|...:..|..:..||..|           .||:. ||:.|          :.:.:|:.:..|..
Yeast   226 IEGTRYSFLVENENKKLPP-----------APTVF-GLLTF----------SRIDRLIWKAYKHC 268

  Fly   125 V--AQLRNIDVNDISIS-----DSLNRTARAIPNYV-------LSQA----VANSSGSPGDALFP 171
            :  |.:.::|:|:.||:     :..::..|.:||.:       :||.    |::........|.|
Yeast   269 LGNADIWDLDINNKSIAILANFEMSSKKGRLLPNIICYFKAVFISQLFLAFVSSFLNFVPSLLMP 333

  Fly   172 KSLDKAGPLEPIQPPVEEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLR 236
            :.|                        |.::......||.::     |.:|::....::......
Yeast   334 RIL------------------------SYVNDPKSKSWNLVS-----LYVSSMLVSKIIATTCRG 369

  Fly   237 QRL-MGAR----MRIACCSLIYRKTLRLSM----KTAGQTPA----------------------- 269
            |.| :|.:    :|....|.||.||||.::    .|:.|..|
Yeast   370 QGLFLGEKGTMQLRTVLISNIYSKTLRRTILKDSTTSLQKNASTSFEENPDSSEAEPRKKSSRKD 434

  Fly   270 GYLINLLSNDVNRLDYGFIFMHWIWI------MPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVP 328
            ..:.|::|.|..::...   |:..::      |.:.|::..|.:   :|..|..|... ||..:|
Yeast   435 NSVNNVMSIDAFKVSEA---MNTFYLACEAVFMTVTALMILYSL---LGWSAFAGTFA-LLAMIP 492

  Fly   329 VQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIR--- 390
            :....:......:......||.|...::|.:..|:|||:.|||..|...:...|..||:.::
Yeast   493 LNFWCATFYGNYQADQLILTDKRTSGISEALNSIRVIKLLAWENLFYQKIINVRDGEIRLLKKKA 557

  Fly   391 ---YASYLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQL----VAAIWY 448
               :.::|..|:..|:|.....:::|     ....||:|....|:|.|.:.||:.    :|:
Yeast   558 TIFFLNHLIWFFGPTLVSAITFSVFI-----KFQNQTLTPTIAFTALSLFAILRTPMDQIAS--- 614

  Fly   449 PLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINASWDIEKPQKTL 513
              .||...::.:||.||||:  |...|.|...:..:.:.:.|      .:|.:..|:..:....|
Yeast   615 --TVSLLIQSFISLERIQDY--LNESETRKYEILEQSNTKFG------FEDASMEWEAAETSFKL 669

  Fly   514 QSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFI----------------QGDLSY 562
            ::|::..:...|.|:|||.|:||||:|..|||||.::.|.:::                ...::|
Yeast   670 KNISIDFKLNSLNAIIGPTGSGKSSLLLGLLGELNLLSGKIYVPTVESRDDLEIGKDGMTNSMAY 734

  Fly   563 AAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRAR 627
            .:|.|||.:|::::|::|||.|:::::.:|.:.|.|..|.:.:..|.:|.||:.|.||||||:.|
Yeast   735 CSQTPWLISGTIKDNVVFGEIFNKQKFDDVMKSCCLDKDIKAMTAGIRTDVGDGGFSLSGGQQQR 799

  Fly   628 ISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVI-GP--RGRLAQLKATRILVTHQVHFLSE- 688
            |:||||:|..::..::||.|||||.....::::|.: ||  :||      |.|:.:|.:..:::
Yeast   800 IALARAIYSSSRYLILDDCLSAVDPETALYIYEECLCGPMMKGR------TCIITSHNISLVTKR 858

  Fly   689 ADVIVIVDQGRILRQGTYQELINSDLDFARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPF 753
            ||.:||:|:|.:..||...:||.|: :|.|       |....:|:|.|.    |.::
Yeast   859 ADWLVILDRGEVKSQGKPSDLIKSN-EFLR-------ESINNDSKNTTH----NQID-------- 903

  Fly   754 IDGVKDGYQQLRKQSSSVHGSKSLDSTQLD-DNVDEDDLAEAQASGGISPRVWYEYFHAGSTLLS 817
               :|......:.::....|..|.|....: :|.:|   .:.:.|...|...|...:..|..
Yeast   904 ---LKRSTTSKKTKNGDPEGGNSQDEVCAEVENFEE---TKMEGSVKFSAYKWLADYFGGLG--- 959

  Fly   818 FSFMVFVMVMSQV----VCSSSDFFANIWTQQEHQRSQGEATFSTFE----CMYIYGALIIAVVI 874
               :|||...|.:    :..|..|:...|.......|:....:...|    ..::...:||.:|.
Yeast   960 ---VVFVFTSSSILIHGITLSQGFWLRYWLDTGSSGSKSTWLYRIVEGHSNIYFLLTYIIIGLVS 1021

  Fly   875 MTTFRGFLFFKIC--MHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAM 937
            .....|.::..|.  .:.:|.:..::.:.||:|.:||.:.||:|||:|||||||..||:.|....
Yeast  1022 SFLTSGKVWIAIISGTNVTKKIFAKLLSSILYAKLRFHNVTPTGRIMNRFSKDMDIIDQQLIPNF 1086

  Fly   938 MDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLS 1002
            .......:|...|:::||.:.|..:...:.:..:...:..||||.|::|||::.|..||:....:
Yeast  1087 EGLSYSVVVCLWIILLIGYVTPQFLLFAIPLCALYYTVCTLYLRASRELKRIDNINISPIHQLFA 1151

  Fly  1003 ASLTGLAIIRSRQLQD---VVAKEFDLLQDVHSSVWQLTMAVNTTLGLWL----DCVSCIFLTSV 1060
            .::.|:..||:  |.|   .:.:....:...::..:.|.||..     |:    |.:..:.|.|.
Yeast  1152 EAIKGVTTIRA--LADERRFITQSLVAIDRSNAPFFYLNMATE-----WITYRVDIIGTLVLFSS 1209

  Fly  1061 TFSFIISS 1068
            :...|:.:
Yeast  1210 SVMIIMKA 1217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	260/1113 (23%)
		ABC_membrane	214..441	CDD:294371	56/270 (21%)
		ABCC_MRP_domain1	495..699	CDD:213217	74/223 (33%)
		ABC_membrane	863..1088	CDD:294371	55/215 (26%)
		ABCC_MRP_domain2	1135..1350	CDD:213211
NFT1	NP_013029.3	MRP_assoc_pro	252..>1218	CDD:188098	251/1075 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I2425
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.900