DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and STE6

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_012713.1	Gene:	STE6 / 853671	SGDID:	S000001692	Length:	1290	Species:	Saccharomyces cerevisiae

Alignment Length:	1456	Identity:	300/1456 - (20%)
Similarity:	553/1456 - (37%)	Gaps:	385/1456 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 LICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANS 161
            :|..|..|...|:||:.:.|                            |.|...  :||..|||.
Yeast    28 MIMIIGTVATGLVPAITSIL----------------------------TGRVFD--LLSVFVANG 62

  Fly   162 SGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQTVEHMWNDMNS---LG---AVLV 220
            |.                    |....::...:.||.::...:|..||..:.|   :|   ...:
Yeast    63 SH--------------------QGLYSQLVQRSMAVMALGAASVPVMWLSLTSWMHIGERQGFRI 107

  Fly   221 LSTLFCCFL----LHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVN 281
            .|.:...:|    :...|..::|:|...:|..|.    :.||.|...|.......|:.:.:
Yeast   108 RSQILEAYLEEKPMEWYDNNEKLLGDFTQINRCV----EELRSSSAEASAITFQNLVAICA---- 164

  Fly   282 RLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQT----ALSKVTSVLRM 342
            .|...|   ::.|.:.|                       ::|.:.|:.|    ..|::..|...
Yeast   165 LLGTSF---YYSWSLTL-----------------------IILCSSPIITFFAVVFSRMIHVYSE 203

  Fly   343 RIAERTDARVGIMNELVQGIQVIKMYAWE----KPFQAVVAEARRSEIKQ----------IRYAS 393
            :....|.....::...:...|::::|..:    |.|:.::.......||.          :|:.:
Yeast   204 KENSETSKAAQLLTWSMNAAQLVRLYCTQRLERKKFKEIILNCNTFFIKSCFFVAANAGILRFLT 268

  Fly   394 ---YLRGFYL-STMVFTERSTLYIT-----LAAAALMGQTITADFVFSAASYYNILQLVAAIWYP 449
               :::||:. |.|:  ::..|.|.     ..:..::|.|:.           |.|..:..:
Yeast   269 LTMFVQGFWFGSAMI--KKGKLNINDVITCFHSCIMLGSTLN-----------NTLHQIVVL--- 317

  Fly   450 LAVSFGAEALVSLRRIQDFLMLEG--REERTQGLTHK--RDQEGGDSRAVTIKDINASWDIEKPQ 510
                  .:..|::.:|.. |:.:|  |....:.:.|:  .|....|   :|..:::.|:.....:
Yeast   318 ------QKGGVAMEKIMT-LLKDGSKRNPLNKTVAHQFPLDYATSD---LTFANVSFSYPSRPSE 372

  Fly   511 KTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQG-------------DLSY 562
            ..|::::|....||...::|..|:|||::..|||......:|.:.|.|             :::.
Yeast   373 AVLKNVSLNFSAGQFTFIVGKSGSGKSTLSNLLLRFYDGYNGSISINGHNIQTIDQKLLIENITV 437

  Fly   563 AAQEPWLFTGSVRNNILFGE-----------EFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGER 616
            ..|...||..::|.|||.|.           ..:|...::..:...|......||:|.:||:|..
Yeast   438 VEQRCTLFNDTLRKNILLGSTDSVRNADCSTNENRHLIKDACQMALLDRFILDLPDGLETLIGTG 502

  Fly   617 GASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTH 681
            |.:|||||:.|:::|||..:...|..:|:.:||:|. |.|:|..:.|    |..:...|.|::||
Yeast   503 GVTLSGGQQQRVAIARAFIRDTPILFLDEAVSALDI-VHRNLLMKAI----RHWRKGKTTIILTH 562

  Fly   682 QVHFLSEADVIVIVDQGRILRQGTYQELI--------------NSDLDFARLLERPKEEE----- 727
            ::..:...|.:.::.:|.::..||..||:              |...|...:::...||:
Yeast   563 ELSQIESDDYLYLMKEGEVVESGTQSELLADPTTTFSTWYHLQNDYSDAKTIVDTETEEKSIHTV 627

  Fly   728 EGENSRNQTSPLS--VNSLESDDED-IPFIDGVKD-----------------GY---QQLRKQSS 769
            |..||:.:|..|.  :::|..|:.| :.|.:.:..                 ||   ||...:||
Yeast   628 ESFNSQLETPKLGSCLSNLGYDETDQLSFYEAIYQKRSNVRTRRVKVEEENIGYALKQQKNTESS 692

  Fly   770 SVHGSKSLDSTQLDDNVDED---------DLAEAQASGGISPRVWYEYFHAGSTLLSFSFMVFVM 825
            :  |.:.|...|:...:.:.         .|..:..:|..:|...|          :|||::..:
Yeast   693 T--GPQLLSIIQIIKRMIKSIRYKKILILGLLCSLIAGATNPVFSY----------TFSFLLEGI 745

  Fly   826 VMSQVVCSSSDFFANIWTQQEHQRSQGEATFSTFECMYIYGALIIAVV----IMTTFRGFLFFKI 886
            |.|....:.|..:...|:                       .|::.|.    |....:|||....
Yeast   746 VPSTDGKTGSSHYLAKWS-----------------------LLVLGVAAADGIFNFAKGFLLDCC 787

  Fly   887 CMHASKVLHDRMFACILHATMRFFD------TTPSGRILNRFSKDMGAIDELLPRAMMDFIQIAL 945
            ..:....|.:.:...:....|.:|.      :..|..:||........:.|.| .||..|:.::.
Yeast   788 SEYWVMDLRNEVMEKLTRKNMDWFSGENNKASEISALVLNDLRDLRSLVSEFL-SAMTSFVTVST 851

  Fly   946 V------------------MFGILIVI-----GILNPVLVAAMLVVAVVDVLILKLYLRPSQDLK 987
            :                  ||.::|:.     |||..........||.::..:.::.    .::|
Yeast   852 IGLIWALVSGWKLSLVCISMFPLIIIFSAIYGGILQKCETDYKTSVAQLENCLYQIV----TNIK 912

  Fly   988 RLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLD-- 1050
            .::  |....| |...:...|.|    ::|.:.:|.                |:.|..|:.:.
Yeast   913 TIK--CLQAEF-HFQLTYHDLKI----KMQQIASKR----------------AIATGFGISMTNM 954

  Fly  1051 ---CVSCIF----LTSVTFSFIISSE--TTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTS 1106
               |:..|.    |..|......|.|  ||::    |.:...|..|.:|.. :..::...:..:.
Yeast   955 IVMCIQAIIYYYGLKLVMIHEYTSKEMFTTFT----LLLFTIMSCTSLVSQ-IPDISRGQRAASW 1014

  Fly  1107 VERVL--QYTELEQE----PALG---------EKTPPQQWPTRGQVEFRNMSCRYDPNGSP--VL 1154
            :.|:|  ::..||.|    ..:|         ||.|        .|..:|::..| |:...  |.
Yeast  1015 IYRILDEKHNTLEVENNNARTVGIAGHTYHGKEKKP--------IVSIQNLTFAY-PSAPTAFVY 1070

  Fly  1155 RNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHIE-GEIFIDGIETGTISLEILRTRISIIPQ 1218
            :|:|..:..|..:||:|.:|.|||:|:..|.:|.:.| |:|.|||.:....:|..||..||::.|
Yeast  1071 KNMNFDMFCGQTLGIIGESGTGKSTLVLLLTKLYNCEVGKIKIDGTDVNDWNLTSLRKEISVVEQ 1135

  Fly  1219 DPVLFSATIRYNL--DPFERYTDAELWSALEDVELRKAI----PGLDYMVTERGGNFSVGQRQLL 1277
            .|:||:.|||.||  ...:...:.|::.||:.|.:...:    .|||..:...  ..|.||.|.|
Yeast  1136 KPLLFNGTIRDNLTYGLQDEILEIEMYDALKYVGIHDFVISSPQGLDTRIDTT--LLSGGQAQRL 1198

  Fly  1278 CLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAG 1342
            |:|||:||.:|:|:|||.|:.:|..:.::|...::........:.:.|....:...:.|.|:..|
Yeast  1199 CIARALLRKSKILILDECTSALDSVSSSIINEIVKKGPPALLTMVITHSEQMMRSCNSIAVLKDG 1263

  Fly  1343 VAVE---FDVPYLLLKKSQGHLRQMV 1365
            ..||   ||..|    .::|.|.|:|
Yeast  1264 KVVERGNFDTLY----NNRGELFQIV 1285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	300/1456 (21%)
		ABC_membrane	214..441	CDD:294371	40/263 (15%)
		ABCC_MRP_domain1	495..699	CDD:213217	58/227 (26%)
		ABC_membrane	863..1088	CDD:294371	46/268 (17%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	72/226 (32%)
STE6	NP_012713.1	MdlB	24..605	CDD:224055	133/691 (19%)
STE6	NP_012713.1	MdlB	702..1289	CDD:224055	146/665 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100