DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and YOR1

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_011797.3	Gene:	YOR1 / 853198	SGDID:	S000003513	Length:	1477	Species:	Saccharomyces cerevisiae

Alignment Length:	1479	Identity:	435/1479 - (29%)
Similarity:	695/1479 - (46%)	Gaps:	241/1479 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRKKQ 76
            |..|.||||.:.|.|.:|:|..|.:|.:..:||.:.......|.|.|..|.......|::.:|.:
Yeast   109 PLFHTNIISNMFFWWVLPILRVGYKRTIQPNDLFKMDPRMSIETLYDDFEKNMIYYFEKTRKKYR 173

  Fly    77 KPH--------LRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDV 133
            |.|        :.||                      |.....||..||..|:|
Yeast   174 KRHPEATEEEVMENA----------------------KLPKHTVLRALLFTFKK----------- 205

  Fly   134 NDISISDSLNRTARAIPNYVLS--QAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATA 196
                             .|.:|  .|:..:..|..:.:..|.|            :|.|:..|..
Yeast   206 -----------------QYFMSIVFAILANCTSGFNPMITKRL------------IEFVEEKAIF 241

  Fly   197 VRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSM 261
            ....:::.:.:      ::||.|::......|  :|.....:|.|.:.:........:|....|.
Yeast   242 HSMHVNKGIGY------AIGACLMMFVNGLTF--NHFFHTSQLTGVQAKSILTKAAMKKMFNASN 298

  Fly   262 KTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKT 326
            ......|.|.:.:.::.|:.|:::...|..::...|....:...|:.:|:|..|:|| :|:....
Yeast   299 YARHCFPNGKVTSFVTTDLARIEFALSFQPFLAGFPAILAICIVLLIVNLGPIALVG-IGIFFGG 362

  Fly   327 VPVQTALSKVTSVLRMRIAER--TDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQI 389
            ..:.....|:  :|..|||..  |||||.:|.|::..|::||.|.||..::..:.:.|..||.::
Yeast   363 FFISLFAFKL--ILGFRIAANIFTDARVTMMREVLNNIKMIKYYTWEDAYEKNIQDIRTKEISKV 425

  Fly   390 RYASYLRGFYLS-TMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVS 453
            |.....|.|.:: .|.....::|...||...:.........:|::.|.:.:|.| ...:.|:|:.
Yeast   426 RKMQLSRNFLIAMAMSLPSIASLVTFLAMYKVNKGGRQPGNIFASLSLFQVLSL-QMFFLPIAIG 489

  Fly   454 FGAEALVSLRRIQDFL---------MLEGR----------------------------------E 475
            .|.:.::.|.|:|..|         |:|.:                                  |
Yeast   490 TGIDMIIGLGRLQSLLEAPEDDPNQMIEMKPSPGFDPKLALKMTHCSFEWEDYELNDAIEEAKGE 554

  Fly   476 ERTQGLTHKRDQEG--GDSRAVT---------IKDINASWDIEKPQ-KTLQSINLQIEKGQLCAV 528
            .:.:|..:|:.::.  |...|.|         :||.:...|:||.. :..:.:|..|:||:...:
Yeast   555 AKDEGKKNKKKRKDTWGKPSASTNKAKRLDNMLKDRDGPEDLEKTSFRGFKDLNFDIKKGEFIMI 619

  Fly   529 IGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVT 593
            .||:|.||||:|..:.|.:...||.|.:.|||..... ||:...|||:||:||..|::::|.||.
Yeast   620 TGPIGTGKSSLLNAMAGSMRKTDGKVEVNGDLLMCGY-PWIQNASVRDNIIFGSPFNKEKYDEVV 683

  Fly   594 RCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHL 658
            |.|:|..|...||.||.|.:||||.:|||||:|||:|||:|||...|||.||.|||||:.||:|:
Yeast   684 RVCSLKADLDILPAGDMTEIGERGITLSGGQKARINLARSVYKKKDIYLFDDVLSAVDSRVGKHI 748

  Fly   659 FDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLERP 723
            .||.:  .|.||  ..||||.|||:..:..|..::::.....:..||..||
Yeast   749 MDECL--TGMLA--NKTRILATHQLSLIERASRVIVLGTDGQVDIGTVDEL-------------- 795

  Fly   724 KEEEEGENSRNQT--SPLSVNSLESDDED-------------IPFIDGVKDGYQQLRKQSSSVHG 773
                   .:||||  :.|..:|..|:.||             :.:...||: ..:|:|:::.:..
Yeast   796 -------KARNQTLINLLQFSSQNSEKEDEEQEAVVAGELGQLKYESEVKE-LTELKKKATEMSQ 852

  Fly   774 SKSLDSTQLDDNVDEDDLAEAQASGGISPRVWYEYFHAGSTLLSFSFMVF--VMVMSQVVCSSSD 836
            :.:......|.:...   .|.:|...||.:::.||..|......|..:..  ::|:....||
Yeast   853 TANSGKIVADGHTSS---KEERAVNSISLKIYREYIKAAVGKWGFIALPLYAILVVGTTFCS--- 911

  Fly   837 FFANIWTQ--QEHQRSQGEATFSTFECMYIYGALIIAVVIMTTFRGFLFFKIC---MHASKVLHD 896
            .|:::|..  .|::......:|    .|.:|...:.|..|   |....|..:|   :.|||.|:.
Yeast   912 LFSSVWLSYWTENKFKNRPPSF----YMGLYSFFVFAAFI---FMNGQFTILCAMGIMASKWLNL 969

  Fly   897 RMFACILHATMRFFDTTPSGRILNRFSKDMGAID-ELLPRAMMDFIQIALVMFGILIVIGILNPV 960
            |....|||..|.:.||||.|||||||:||..::| ||.....:...|.|.:: |:.::..:..|.
Yeast   970 RAVKRILHTPMSYIDTTPLGRILNRFTKDTDSLDNELTESLRLMTSQFANIV-GVCVMCIVYLPW 1033

  Fly   961 LVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFD 1025
            ...|:..:.|:.|||...|....:::||||.:.||.|:::|:..|.|:..|::.:.|:....:.|
Yeast  1034 FAIAIPFLLVIFVLIADHYQSSGREIKRLEAVQRSFVYNNLNEVLGGMDTIKAYRSQERFLAKSD 1098

  Fly  1026 LLQDVHSSVWQLTMAVNTTLGLWLDCVSCIF-----LTSVTFSFIISSETTYSGNVGLAIAQAMI 1085
            .|.:..:....|.:.:...:|::||.|:..|     |..||.:|.||     :.:||:.:...:.
Yeast  1099 FLINKMNEAGYLVVVLQRWVGIFLDMVAIAFALIITLLCVTRAFPIS-----AASVGVLLTYVLQ 1158

  Fly  1086 LTGMVQYGVRQVAESLQQMTSVERVLQY-TELEQEPAL--GEKTPPQQWPTRGQVEFRNMSCRYD 1147
            |.|::...:|.:.::...|.|.||::.| |||..|.:.  .|.|||:.||:.|::.|.|:...|.
Yeast  1159 LPGLLNTILRAMTQTENDMNSAERLVTYATELPLEASYRKPEMTPPESWPSMGEIIFENVDFAYR 1223

  Fly  1148 PNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHI-EGEIFIDGIETGTISLEILRT 1211
            |....||:||||.|::|.|:||.||||||||:::.||:||..: .|:|.||.::...:.|..||.
Yeast  1224 PGLPIVLKNLNLNIKSGEKIGICGRTGAGKSTIMSALYRLNELTAGKILIDNVDISQLGLFDLRR 1288

  Fly  1212 RISIIPQDPVLFSATIRYNLDPFERYTDAELWSA-----------LEDVELRKAIPG-------- 1257
            :::|||||||||..|||.|||||...||.|||.|           |.:|:|:|....
Yeast  1289 KLAIIPQDPVLFRGTIRKNLDPFNERTDDELWDALVRGGAIAKDDLPEVKLQKPDENGTHGKMHK 1353

  Fly  1258 --LDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTV 1320
              ||..|.|.|.|||:|:||||.|.||::|.:|:|:|||||::||.:||..||..|..:|..||:
Yeast  1354 FHLDQAVEEEGSNFSLGERQLLALTRALVRQSKILILDEATSSVDYETDGKIQTRIVEEFGDCTI 1418

  Fly  1321 LTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEATG 1369
            |.:||||.|:::.|||:|::.|...|||.|:.|..:.....|.|...:|
Yeast  1419 LCIAHRLKTIVNYDRILVLEKGEVAEFDTPWTLFSQEDSIFRSMCSRSG 1467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	434/1475 (29%)
		ABC_membrane	214..441	CDD:294371	52/229 (23%)
		ABCC_MRP_domain1	495..699	CDD:213217	91/213 (43%)
		ABC_membrane	863..1088	CDD:294371	70/233 (30%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	110/236 (47%)
YOR1	NP_011797.3	MRP_assoc_pro	92..1468	CDD:188098	435/1479 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710