DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and BPT1

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_013086.1	Gene:	BPT1 / 850645	SGDID:	S000003938	Length:	1559	Species:	Saccharomyces cerevisiae

Alignment Length:	1481	Identity:	450/1481 - (30%)
Similarity:	692/1481 - (46%)	Gaps:	255/1481 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RKN---PRQHANIISQLIFAWAIPLL---YRGSRRGLNTDDLTQCLKEDRS----------EQLG 57
            :||   |..|  ::|.:.|.|...|:   ||..:           :|:...          :.:.
Yeast   211 KKNGWYPPVH--VLSYITFIWMNKLIVETYRNKK-----------IKDPNQLPLPPVDLNIKSIS 262

  Fly    58 DRLEDQWFKELERSHRKKQKPHLRNALFRCF---LGPTIINGLICFIYIVIKTLIPAVLAQLLIQ 119
            ...:..|  |||:...       ||:|:|..   .|.||   .:..:|.....|:..|..|.|..
Yeast   263 KEFKANW--ELEKWLN-------RNSLWRAIWKSFGRTI---SVAMLYETTSDLLSVVQPQFLRI 315

  Fly   120 FQKTPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQ 184
            |                  .|.||                           |::..|       .
Yeast   316 F------------------IDGLN---------------------------PETSSK-------Y 328

  Fly   185 PPVEEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLF-----CCFLLH--HVDLRQRLMGA 242
            ||                            |..|.:..|||     ..||.:  ::.:.:..:|.
Yeast   329 PP----------------------------LNGVFIALTLFVISVVSVFLTNQFYIGIFEAGLGI 365

  Fly   243 RMRIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQ--AMLTCY 305
            |..:|  ||:|:|:|||::....:...|.::||:|.||.|:...|.....|...|:|  .:||.
Yeast   366 RGSLA--SLVYQKSLRLTLAERNEKSTGDILNLMSVDVLRIQRFFENAQTIIGAPIQIIVVLTS- 427

  Fly   306 LIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAW 370
            |.|| :|...|.|:|.:.: .:|:...||:....|.....:..|.|:..:.||:..|:.||:|||
Yeast   428 LYWL-LGKAVIGGLVTMAI-MMPINAFLSRKVKKLSKTQMKYKDMRIKTITELLNAIKSIKLYAW 490

  Fly   371 EKPFQAVVAEARRS-EIKQIRYASYLRGFYLSTMVFTERS--TLYITLAAAALMG----QTITAD 428
            |:|..|.:...|.. |:|..|...     .:|.:::...:  .|.:|.:...|..    ..::..
Yeast   491 EEPMMARLNHVRNDMELKNFRKIG-----IVSNLIYFAWNCVPLMVTCSTFGLFSLFSDSPLSPA 550

  Fly   429 FVFSAASYYNILQLVAAIW-YPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDS 492
            .||.:.|.:|||.  :||: .|..::...|..||:.|::.||:   .:|.......:.| ...|.
Yeast   551 IVFPSLSLFNILN--SAIYSVPSMINTIIETSVSMERLKSFLL---SDEIDDSFIERID-PSADE 609

  Fly   493 R---AVTIKDINASWD---------------------IEKPQKTLQSI-NLQIEKGQLCAVIGPV 532
            |   |:.:.:|...|.                     |...|..|::| :.:.::|.|..|:|.|
Yeast   610 RALPAIEMNNITFLWKSKEVLTSSQSGDNLRTDEESIIGSSQIALKNIDHFEAKRGDLVCVVGRV 674

  Fly   533 GAGKSSILQLLLGELPVIDGG--------VFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRY 589
            |||||:.|:.:||:||.:.|.        :.....::|.:||.|:...|||.|||||.:||:..|
Yeast   675 GAGKSTFLKAILGQLPCMSGSRDSIPPKLIIRSSSVAYCSQESWIMNASVRENILFGHKFDQDYY 739

  Fly   590 QEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHV 654
            ....:.|.|..|.:.||:||:|||||:|.||||||:||:|||||||..|.|||:||.||||||.|
Yeast   740 DLTIKACQLLPDLKILPDGDETLVGEKGISLSGGQKARLSLARAVYSRADIYLLDDILSAVDAEV 804

  Fly   655 GRHLFDEVIGPRGRLAQLK-ATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFAR 718
            .:::.:.|:  .|:.|.|| .|.||.|:.|..|..:.:|..::.|.|:.||.|::::|...:.::
Yeast   805 SKNIIEYVL--IGKTALLKNKTIILTTNTVSILKHSQMIYALENGEIVEQGNYEDVMNRKNNTSK 867

  Fly   719 LLERPKEE-----EEGENSRNQT---------SPLSVNSLESDDEDIPFIDGVKDGYQQL----- 764
             |::..||     :.|..|..||         .||.:...||:.||    :.|.:...:|
Yeast   868 -LKKLLEEFDSPIDNGNESDVQTEHRSESEVDEPLQLKVTESETED----EVVTESELELIKANS 927

  Fly   765 RKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQ 829
            |:.|.:....:.....|||........||....|.:..:::..|..|...|....|.:| |::::
Yeast   928 RRASLATLRPRPFVGAQLDSVKKTAQKAEKTEVGRVKTKIYLAYIKACGVLGVVLFFLF-MILTR 991

  Fly   830 VVCSSSDFFANIWTQQEHQRSQGEATFSTFECMY--IYGALIIAVVIMTTFRGFLFFKIC-MHAS 891
            |...:.:|:...|::...:....|..:     |:  :|..:.:|.......|..:....| :..|
Yeast   992 VFDLAENFWLKYWSESNEKNGSNERVW-----MFVGVYSLIGVASAAFNNLRSIMMLLYCSIRGS 1051

  Fly   892 KVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGI 956
            |.||:.|...::.:.|.||:|||.|||:||||.||.|:|..|......|.:..|.....:|::|.
Yeast  1052 KKLHESMAKSVIRSPMTFFETTPVGRIINRFSSDMDAVDSNLQYIFSFFFKSILTYLVTVILVGY 1116

  Fly   957 LNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRS-RQLQDVV 1020
            ..|..:...:.:.|:.:.....|:..|::||||..|..||:.|.:|.||.|.:||.: ...:..:
Yeast  1117 NMPWFLVFNMFLVVIYIYYQTFYIVLSRELKRLISISYSPIMSLMSESLNGYSIIDAYDHFERFI 1181

  Fly  1021 AKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSET---TYSGNVGLAIAQ 1082
            ...::.:|.....|:.. .:.|..|.:.|..:....:.:.....:.:..|   ..||.|||.::.
Yeast  1182 YLNYEKIQYNVDFVFNF-RSTNRWLSVRLQTIGATIVLATAILALATMNTKRQLSSGMVGLLMSY 1245

  Fly  1083 AMILTGMVQYGVRQVAESLQQMTSVERVLQYTEL--EQEPALGEKTPPQQWPTRGQVEFRNMSCR 1145
            ::.:||.:.:.||........:.||||:::|.||  |.:....||.|.:.||::|.:||:|.|.:
Yeast  1246 SLEVTGSLTWIVRTTVTIETNIVSVERIVEYCELPPEAQSINPEKRPDENWPSKGGIEFKNYSTK 1310

  Fly  1146 YDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFR-LAHIEGEIFIDGIETGTISLEIL 1209
            |..|..|||.|:|:.||...|||||||||||||:|..|||| |...||:|.||||:...|.|..|
Yeast  1311 YRENLDPVLNNINVKIEPCEKVGIVGRTGAGKSTLSLALFRILEPTEGKIIIDGIDISDIGLFDL 1375

  Fly  1210 RTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAIPG----------------- 1257
            |:.::|||||...|..|::.|||||.||::.||..|:|...|:..:..
Yeast  1376 RSHLAIIPQDAQAFEGTVKTNLDPFNRYSEDELKRAVEQAHLKPHLEKMLHSKPRGDDSNEEDGN 1440

  Fly  1258 ----LDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQC 1318
                ||..:.|.|.|.|||||||||||||:|..:|:||||||||:||.:||.:||.|||.:||..
Yeast  1441 VNDILDVKINENGSNLSVGQRQLLCLARALLNRSKILVLDEATASVDMETDKIIQDTIRREFKDR 1505

  Fly  1319 TVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEATG 1369
            |:||:|||:.||:|||:|||:|.|...|||.|..||.........:.|..|
Yeast  1506 TILTIAHRIDTVLDSDKIIVLDQGSVREFDSPSKLLSDKTSIFYSLCEKGG 1556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	448/1477 (30%)
		ABC_membrane	214..441	CDD:294371	67/242 (28%)
		ABCC_MRP_domain1	495..699	CDD:213217	90/234 (38%)
		ABC_membrane	863..1088	CDD:294371	60/231 (26%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	121/236 (51%)
BPT1	NP_013086.1	MRP_assoc_pro	222..1556	CDD:188098	445/1466 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720