Protein Alignment Cftr and ABCC11

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_001319112.1
• Gene: ABCC11 / 839922
• AraportID: AT1G30420
• Length: 1495
• Species: Arabidopsis thaliana
• Alignment Length: 1391
• Identity: 432/1391 - (31%)
• Similarity: 693/1391 - (49%)
• Gaps: 173/1391 - (12%)

  Fly    12 PRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRKKQ 76
            |.::|:|.|.:.|:|..||:..|.|:.:...|:.|..:.|::|.|..|.:..|.:|     .::.
plant   228 PERYASIFSGIYFSWMTPLMQLGYRKPITERDVWQLDQWDQTETLIKRFQRCWTEE-----SRRP 287

  Fly    77 KP----HLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDIS 137
            ||    .|.|:|.|.|.    :.|:....:.:.:.:.|.:|:.:|
plant   288 KPWLLRALNNSLGRRFW----LGGIFKVGHDLSQFVGPVILSHIL-------------------- 328

  Fly   138 ISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILD 202
                                   .|...||..:
plant   329 -----------------------QSMIEGDPAW-------------------------------- 338

  Fly   203 QTVEHMWNDMNSLG---AVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKTA 264
              |.:::..:...|   .||..|..|     .||.    .:|.|:|....:.|:.|:|||:.|..
plant   339 --VGYVYAFLIFFGVTFGVLCQSQYF-----QHVG----RVGFRLRSTLVAAIFHKSLRLTNKAR 392

  Fly   265 GQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPV 329
            ....:|.:.|:::.|.|.|......:|.:|..|.:.:::..|::..:|:.:|.|.: :|...:|.
plant   393 KNFASGKVTNMITTDANALQLIAEQLHGLWSAPFRIIVSMVLLYQQLGVASIFGSL-ILFLLIPF 456

  Fly   330 QTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASY 394
            ||.:.:....|.....:.||.||||:.|::..:.::|.|||||.|::.:...|..|:...|.|..
plant   457 QTLIVRKMRKLTKEGLQWTDKRVGIIYEILASMDIVKCYAWEKSFESRIQGIRNEELSWFRKAQL 521

  Fly   395 LRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEAL 459
            |..|....:..|......::.....|:|..:|....|::.|.:.:|:...:. .|..:|....|.
plant   522 LSAFNSFILNSTPVVVTLVSFGVYVLLGGDLTPARAFTSLSLFAVLRSPLST-LPNLISQAVNAN 585

  Fly   460 VSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINASWDIEKPQKTLQSINLQIEKGQ 524
            |||:||::.|:   .|||.  |......:.| :.|::||:...|||.:..:.||..|||:|..|.
plant   586 VSLQRIEELLL---SEERI--LAQNPPLQPG-APAISIKNGYFSWDSKTSKPTLSDINLEIPVGS 644

  Fly   525 LCAVIGPVGAGKSSILQLLLGELPVID-GGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKR 588
            |.|::|..|.||:|::..:||||...: ..|.|:|.::|..|..|:|..::|.|||||.:|:.:|
plant   645 LVAIVGGTGEGKTSLISAMLGELSHAETSSVDIRGSVAYVPQVSWIFNATLRENILFGSDFESER 709

  Fly   589 YQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAH 653
            |.......||..|....|..|:|.:||||.::||||:.|:|:|||||..:.||:.|||.||:|||
plant   710 YWRAIDVTALQHDLDLFPGRDRTEIGERGVNISGGQKQRVSMARAVYSNSDIYIFDDPFSALDAH 774

  Fly   654 VGRHLFDEVIGPRGRLAQLKA-TRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFA 717
            |...:||..:     ..:||. ||:|||:|:|||...|.|::|.:|.|..:|.:.||..|...|.
plant   775 VAHQVFDSCV-----KHELKGKTRVLVTNQLHFLPLMDRIILVSEGMIKEEGNFAELSKSGTLFK 834

  Fly   718 RLLERPKE----EEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSLD 778
            :|:|...:    :|...|..|.:......:::..:..:..|...|.|...|.||
plant   835 KLMENAGKMDATQEVNTNDENISKLGPTVTIDVSERSLGSIQQGKWGRSMLVKQ----------- 888

  Fly   779 STQLDDNVDEDDLAEAQASGGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWT 843
                          |.:.:|.||..|...|..|...|.....::...:.::|:...|..:.:|||
plant   889 --------------EERETGIISWDVVMRYNKAVGGLWVVMILLVCYLTTEVLRVLSSTWLSIWT 939

  Fly   844 QQEHQRSQGEATFSTFECMYIYGALIIAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHATMR 908
            .|...:|.....:     :.:|..|....|.:|....|......:||:|.|||.|...||.|.|.
plant   940 DQSTPKSYSPGFY-----IVVYALLGFGQVAVTFTNSFWLISSSLHAAKRLHDAMLNSILRAPML 999

  Fly   909 FFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDV 973
            ||:|.|:||::||||||:|.||..:...|..|:.....:.....:|||::.:.:.|::.:.::..
plant  1000 FFETNPTGRVINRFSKDIGDIDRNVANLMNMFMNQLWQLLSTFALIGIVSTISLWAIMPLLILFY 1064

  Fly   974 LILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLT 1038
            .....|...|::::||:.:.|||:::....:|.||:.||:.:..|.:||......|.:.   :.|
plant  1065 ATYIYYQSTSREVRRLDSVTRSPIYALFGEALNGLSSIRAYKAYDRMAKINGKSMDNNI---RFT 1126

  Fly  1039 MAVNTTLGLWLDCVS------CIFLTSVTFSFI----ISSETTYSGNVGLAIAQAMILTGMVQYG 1093
            :| :|:...||...|      .|:||: ||:.:    ..::..::..:||.::..:.:|.::...
plant  1127 LA-STSSNRWLTIRSESLGGVMIWLTA-TFAVLRYGNAENQAVFASTMGLLLSYTLNITTLLSGV 1189

  Fly  1094 VRQVAESLQQMTSVERVLQYTELEQEPA--LGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRN 1156
            :||.:::...:.|||||..|.:|..|..  :....|...||:||.::|.::..||.|...|||..
plant  1190 LRQASKAENSLNSVERVGNYIDLPSEATAIIENNRPVSGWPSRGSIQFEDVHLRYRPGLPPVLHG 1254

  Fly  1157 LNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHIE-GEIFIDGIETGTISLEILRTRISIIPQDP 1220
            |:..:....|||:||||||||||::.||:|:..:| |.|.||..:.....|..||..:|||||.|
plant  1255 LSFFVYPSEKVGVVGRTGAGKSSMLNALYRIVELEKGRILIDDYDVAKFGLTDLRRVLSIIPQSP 1319

  Fly  1221 VLFSATIRYNLDPFERYTDAELWSALEDVELRKAIP----GLDYMVTERGGNFSVGQRQLLCLAR 1281
            ||||.|:|:|:|||..:.||:||.|||...::..|.    |||..|:|.|.||||||||||.|||
plant  1320 VLFSGTVRFNIDPFSEHNDADLWEALERAHIKDVIDRNPFGLDAEVSEGGENFSVGQRQLLSLAR 1384

  Fly  1282 AILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVE 1346
            |:||.:|:|.||||||:||.:||:|||||||.:||.||:|.:||||:|::|.|:|:|:.:|..:|
plant  1385 ALLRRSKILFLDEATASVDVRTDSLIQRTIREEFKSCTMLIIAHRLNTIIDCDKILVLSSGQVLE 1449

  Fly  1347 FDVPYLLLKKSQGHLRQMVEATGGES 1372
            :|.|..||.:......:||.:||.|:
plant  1450 YDSPQELLSRDTSAFFKMVHSTGPEN 1475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	427/1373 (31%)
ABCC11	NP_001319112.1	PLN03232	1..1495	CDD:215640	432/1391 (31%)