Protein Alignment Cftr and ABCC12

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_001319111.1
• Gene: ABCC12 / 839921
• AraportID: AT1G30410
• Length: 1498
• Species: Arabidopsis thaliana
• Alignment Length: 1395
• Identity: 433/1395 - (31%)
• Similarity: 688/1395 - (49%)
• Gaps: 184/1395 - (13%)

  Fly    12 PRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRKKQ 76
            |.:||:|.|::.|.|..||:..|.|:.:...|:.|..|.|::|.|..|.:..|.:|     .::.
plant   228 PERHASIFSRIYFGWITPLMQLGYRKPITEKDVWQLDKWDQTETLIKRFQRCWTEE-----SRRP 287

  Fly    77 KPHLRNALFRCFLGPTIINGLICFIYI---VIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISI 138
            ||.|..||.....|...:.|:.....|   :.:.:.|.:|:.||...|:...|.:..:....|.:
plant   288 KPWLLRALNNSLGGRFWLAGIFKVTRIGNDLSQFVGPVILSHLLRSMQEGDPAWVGYVYAFIIFV 352

  Fly   139 SDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQ 203
            ..:|.         ||.:|                                             |
plant   353 GVTLG---------VLCEA---------------------------------------------Q 363

  Fly   204 TVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKTAGQTP 268
            ..:::|.                             :|.|:|....:.|:.|:|||:.:......
plant   364 YFQNVWR-----------------------------VGFRLRSTLVAAIFHKSLRLTHEARKNFA 399

  Fly   269 AGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTAL 333
            :|.:.|:::.|.|.|......:|.:|..|.:.:::..|::..:|:.::.|.: :|...:|:||.:
plant   400 SGKVTNMITTDANALQQISQQLHGLWSAPFRIIVSMILLYQQLGVASLFGSL-ILFLLIPLQTLI 463

  Fly   334 SKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRGF 398
            ......|.....:.||.||||.||::..:..:|.|||||.|::.:...|..|:...|.|..|..|
plant   464 ISKMRKLTKEGLQWTDKRVGITNEILSSMDTVKCYAWEKSFESRIQGIRNEELSWFRKAQLLSAF 528

  Fly   399 YLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPL-----AVSFGAEA 458
            ....:.........::.....|:|..:|....|::.|.:.:|:      :||     .:|....|
plant   529 NSFILNSIPVVVTVVSFGVFVLLGGDLTPARAFTSLSLFAVLR------FPLNMLPNLLSQVVNA 587

  Fly   459 LVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINASWDIEKPQKTLQSINLQIEKG 523
            .|||:||::.|:   .|||.  |......:.| :.|::||:...|||.:..:.||..|||:|..|
plant   588 NVSLQRIEELLL---SEERI--LAQNPPLQPG-TPAISIKNGYFSWDSKTTKPTLSDINLEIPVG 646

  Fly   524 QLCAVIGPVGAGKSSILQLLLGELPVID-GGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRK 587
            .|.|::|..|.||:|::..:||||...: ..|.|:|.::|..|..|:|..:||.|||||.:|:.:
plant   647 TLVAIVGGTGEGKTSLISAMLGELSHAETTSVVIRGSVAYVPQVSWIFNATVRENILFGSDFESE 711

  Fly   588 RYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDA 652
            ||.......||..|...||..|.|.:||||.::||||:.|:|:|||||..:.:|:.||||||:||
plant   712 RYWRAIDATALQHDLDLLPGRDLTEIGERGVNISGGQKQRVSMARAVYSNSDVYIFDDPLSALDA 776

  Fly   653 HVGRHLFDEVIGP--RGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLD 715
            ||...:||..:..  ||:      ||:|||:|:|||...|.|::|.:|.|..:||:.||..|.:.
plant   777 HVAHQVFDSCMKDELRGK------TRVLVTNQLHFLPLMDKIILVSEGMIKEEGTFVELSKSGIL 835

  Fly   716 FARLLERP-KEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQ---LRKQSSSVHGSKS 776
            |.:|:|.. |.:...|.:.|..:.|.:....:.|.....:...|.|.::   |.||
plant   836 FKKLMENAGKMDATQEVNTNDENILKLGPTVTVDVSERNLGSTKQGKRRRSVLIKQ--------- 891

  Fly   777 LDSTQLDDNVDEDDLAEAQASGGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANI 841
                            |.:.:|.||..|...|..|...|.....::...:.::|:..||..:.:|
plant   892 ----------------EERETGIISWNVLMRYKEAVGGLWVVMILLACYLATEVLRVSSSTWLSI 940

  Fly   842 WTQQEHQRSQGEATFSTFECMYIYGALIIAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHAT 906
            ||.|...::.....:     :.:|..|....|.:|....|......:||::.|||.|.:.||.|.
plant   941 WTDQSTSKNYSPGFY-----IVVYALLGFGQVAVTFTNSFWLITSSLHAARRLHDAMLSSILRAP 1000

  Fly   907 MRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVV 971
            |.||.|.|:||::||||||:|.||..:...|..|:.....:.....:||.::.:.:.|::.:.::
plant  1001 MLFFHTNPTGRVINRFSKDIGDIDRNVANLMNMFMNQLWQLLSTFALIGTVSTISLWAIMPLLIL 1065

  Fly   972 DVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVA----KEFD-----LL 1027
            .......|...|::::||:.:.|||:::....:|.||:.||:.:..|.:|    |..|     .|
plant  1066 FYAAYLYYQSTSREVRRLDSVTRSPIYAQFGEALNGLSSIRAYKAYDRMAKINGKSMDNNIRFTL 1130

  Fly  1028 QDVHSSVWQLTMAVNTTLG--LWLDCVSCIFLTSVTFSFIISSETT----YSGNVGLAIAQAMIL 1086
            .:..|:.| ||:.:.|..|  :||         :.||:.:.:..|.    ::..:||.::..:.:
plant  1131 ANTSSNRW-LTIRLETLGGVMIWL---------TATFAVLQNGNTNNQAGFASTMGLLLSYTLNI 1185

  Fly  1087 TGMVQYGVRQVAESLQQMTSVERVLQYTELEQEPA--LGEKTPPQQWPTRGQVEFRNMSCRYDPN 1149
            |.::...:||.:.:...:.|||||..|.:|..|..  :....|...||:.|.::|.::..||.|.
plant  1186 TSLLSGVLRQASRAENSLNSVERVGNYIDLPSEATDIIENNRPVCGWPSGGSIKFEDVHLRYRPG 1250

  Fly  1150 GSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHIE-GEIFIDGIETGTISLEILRTRI 1213
            ..|||..|...:....|||:||||||||||::.||||:..:| |.|.||..:.....|..:|..:
plant  1251 LPPVLHGLTFFVSPSEKVGVVGRTGAGKSSMLNALFRIVEVEKGRIMIDDCDVAKFGLTDVRRVL 1315

  Fly  1214 SIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAIP----GLDYMVTERGGNFSVGQR 1274
            |||||.|||||.|:|:|:|||..:.||.||.||....::..|.    |||..|.|.|.|||||||
plant  1316 SIIPQSPVLFSGTVRFNIDPFSEHNDAGLWEALHRAHIKDVISRNPFGLDAEVCEGGENFSVGQR 1380

  Fly  1275 QLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVM 1339
            |||.||||:||.:|:||||||||:||.:||:|||||||.:||.||:|.:||||:|::|.|:|:|:
plant  1381 QLLSLARALLRRSKILVLDEATASVDVRTDSLIQRTIREEFKSCTMLVIAHRLNTIIDCDKILVL 1445

  Fly  1340 DAGVAVEFDVPYLLLKKSQGHLRQMVEATG 1369
            .:|..:|:|.|..||.:......:||.:||
plant  1446 SSGQVLEYDSPQELLSRDTSAFFRMVHSTG 1475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	429/1380 (31%)
ABCC12	NP_001319111.1	PLN03232	1..1498	CDD:215640	433/1395 (31%)