DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and ABCC1

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_001031116.1	Gene:	ABCC1 / 839920	AraportID:	AT1G30400	Length:	1622	Species:	Arabidopsis thaliana

Alignment Length:	1431	Identity:	460/1431 - (32%)
Similarity:	714/1431 - (49%)	Gaps:	198/1431 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRKKQ 76
            |.:|||:...:.|:|..||:..||:|.|...|:......|::|.|....:..|.||||     |.
plant   227 PERHANLFDSIFFSWLNPLMTLGSKRPLTEKDVWHLDTWDKTETLMRSFQKSWDKELE-----KP 286

  Fly    77 KPHLRNALFR-----------------C--FLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQK 122
            ||.|..||..                 |  |:||.::|.|
plant   287 KPWLLRALNNSLGGRFWWGGFWKIGNDCSQFVGPLLLNEL------------------------- 326

  Fly   123 TPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPV 187
                 |:::.:|
plant   327 -----LKSMQLN----------------------------------------------------- 333

  Fly   188 EEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFL--LHHVDLRQRLM--GARMRIAC 248
                              |..|     :|.:..:|......|  |......|.:|  |.|:|.|.
plant   334 ------------------EPAW-----IGYIYAISIFVGVVLGVLCEAQYFQNVMRVGYRLRSAL 375

  Fly   249 CSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGI 313
            .:.::||:|||:.:...:...|.:.||::.|...|......:|.:|..|.:.::...|::..:|:
plant   376 IAAVFRKSLRLTNEGRKKFQTGKITNLMTTDAESLQQICQSLHTMWSAPFRIIVALVLLYQQLGV 440

  Fly   314 PAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVV 378
            .:|:|.:.|:| ..|:||.:...|..|.....:|||.|:|:|||::..:..:|.||||..||:.|
plant   441 ASIIGALFLVL-MFPIQTVIISKTQKLTKEGLQRTDKRIGLMNEVLAAMDTVKCYAWENSFQSKV 504

  Fly   379 AEARRSEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLV 443
            ...|..|:...|.|..|..|.:..:.........::....:|:|..:|....|::.|.:::|:.
plant   505 QTVRDDELSWFRKAQLLSAFNMFILNSIPVLVTVVSFGVFSLLGGDLTPARAFTSLSLFSVLRF- 568

  Fly   444 AAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINASWDIEK 508
            .....|..::....|.|||.|:::.|   ..|||.  |......|.|.. |::|::...|||.:.
plant   569 PLFMLPNIITQMVNANVSLNRLEEVL---STEERV--LLPNPPIEPGQP-AISIRNGYFSWDSKA 627

  Fly   509 PQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPV-IDGGVFIQGDLSYAAQEPWLFTG 572
            .:.||.:|||.|..|.|.||:|..|.||:|::..:|||||. .|..|.::|.::|..|..|:|..
plant   628 DRPTLSNINLDIPLGSLVAVVGSTGEGKTSLISAMLGELPARSDATVTLRGSVAYVPQVSWIFNA 692

  Fly   573 SVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKP 637
            :||:|||||..||:::|:.|....||..|.:.||.||.|.:||||.::||||:.|:|:|||||..
plant   693 TVRDNILFGAPFDQEKYERVIDVTALQHDLELLPGGDLTEIGERGVNISGGQKQRVSMARAVYSN 757

  Fly   638 AQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILR 702
            :.:.::||||||:|||||:.:|::.|  :..|.|  .||:|||:|:||||:.|.|::|.:|.:..
plant   758 SDVCILDDPLSALDAHVGQQVFEKCI--KRELGQ--TTRVLVTNQLHFLSQVDKILLVHEGTVKE 818

  Fly   703 QGTYQELINSDLDFARLLERPKE-----EEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQ 762
            :|||:||.:|...|.||:|...:     ||.||...:||   ||..:|:.:.:
plant   819 EGTYEELCHSGPLFQRLMENAGKVEDYSEENGEAEVDQT---SVKPVENGNAN------------ 868

  Fly   763 QLRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISPRVWYEYFHAGSTLLSFSFMVFVMVM 827
            .|:|.......||..:|..:.        .|.:.:|.:|.:|...|.:|.........:|...|:
plant   869 NLQKDGIETKNSKEGNSVLVK--------REERETGVVSWKVLERYQNALGGAWVVMMLVICYVL 925

  Fly   828 SQVVCSSSDFFANIWTQQEHQRSQGEATFSTFECMYIYGALIIAVVIMTTFRGFLFFKICMHASK 892
            :||...||..:.:.||.....::.|...::     .:|..|....|.:|....:......::|:|
plant   926 TQVFRVSSSTWLSEWTDSGTPKTHGPLFYN-----IVYALLSFGQVSVTLINSYWLIMSSLYAAK 985

  Fly   893 VLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGIL 957
            .:||.|...||.|.|.||.|.|.|||:|||:||||.||..:...:..|:.....:...:|:|||:
plant   986 KMHDAMLGSILRAPMVFFQTNPLGRIINRFAKDMGDIDRTVAVFVNMFMGSIAQLLSTVILIGIV 1050

  Fly   958 NPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAK 1022
            :.:.:.|::.:.||.......|...|:::||::...||||::....:|.||:.||:.:..|.:|:
plant  1051 STLSLWAIMPLLVVFYGAYLYYQNTSREIKRMDSTTRSPVYAQFGEALNGLSSIRAYKAYDRMAE 1115

  Fly  1023 EFDLLQDVHSSVWQLTMAVNTTLGLWLDCVS--CIFLT---SVTFSFIISSETTYSGNVGLAIAQ 1082
            ......|.:.....:.||.|..||:.|:.:.  .::||   :|..:...:::..|:..:||.::.
plant  1116 INGRSMDNNIRFTLVNMAANRWLGIRLEVLGGLMVWLTASLAVMQNGKAANQQAYASTMGLLLSY 1180

  Fly  1083 AMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQEPAL--GEKTPPQQWPTRGQVEFRNMSCR 1145
            |:.:|..:...:|..:.:...:.|||||..|.|:..|..|  ....||..||:.|.::|.::..|
plant  1181 ALSITSSLTAVLRLASLAENSLNSVERVGNYIEIPSEAPLVIENNRPPPGWPSSGSIKFEDVVLR 1245

  Fly  1146 YDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHIE-GEIFIDGIETGTISLEIL 1209
            |.|...|||..::..|....|||||||||||||||:.||||:..:| |.|.||..:.|...|..|
plant  1246 YRPELPPVLHGVSFLISPMDKVGIVGRTGAGKSSLLNALFRIVELEKGRILIDECDIGRFGLMDL 1310

  Fly  1210 RTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAIP----GLDYMVTERGGNFS 1270
            |..:.||||.|||||.|:|:|||||..:.||:||.:||...|:..|.    |||..|||.|.|||
plant  1311 RKVLGIIPQAPVLFSGTVRFNLDPFSEHNDADLWESLERAHLKDTIRRNPLGLDAEVTEAGENFS 1375

  Fly  1271 VGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDR 1335
            |||||||.||||:||.:|:||||||||.||.:||.|||:|||.:||.||:|.:||||:|::|.|:
plant  1376 VGQRQLLSLARALLRRSKILVLDEATAAVDVRTDVLIQKTIREEFKSCTMLIIAHRLNTIIDCDK 1440

  Fly  1336 IIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEATGGESEALKKTASDSHKRMQRERDERDRDQDES 1400
            ::|:|:|...||..|..||...:....:||::||..:....::.:..:||      .|:.:.|:|
plant  1441 VLVLDSGKVQEFSSPENLLSNGESSFSKMVQSTGTANAEYLRSITLENKR------TREANGDDS 1499

  Fly  1401 Q 1401
            |
plant  1500 Q 1500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	452/1395 (32%)
		ABC_membrane	214..441	CDD:294371	61/230 (27%)
		ABCC_MRP_domain1	495..699	CDD:213217	93/204 (46%)
		ABC_membrane	863..1088	CDD:294371	66/229 (29%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	120/219 (55%)
ABCC1	NP_001031116.1	PLN03130	1..1622	CDD:215595	460/1431 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	86	1.000	Domainoid score	I2776
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720