Protein Alignment Cftr and ABCC5

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_171908.1
• Gene: ABCC5 / 839277
• AraportID: AT1G04120
• Length: 1514
• Species: Arabidopsis thaliana
• Alignment Length: 1424
• Identity: 433/1424 - (30%)
• Similarity: 689/1424 - (48%)
• Gaps: 186/1424 - (13%)

  Fly     1 MDSSAKPTRKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWF 65
            ::..|...:..|...|.::|.:..:|..|||..||:|.|...|:......||::.....|:..|
plant   218 VEEEAACLKVTPYSTAGLVSLITLSWLDPLLSAGSKRPLELKDIPLLAPRDRAKSSYKVLKSNW- 281

  Fly    66 KELERSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRN 130
             :..:|....:.|.|..|:.:.|......|.    ::..:.||:..|...|:..|
plant   282 -KRCKSENPSKPPSLARAIMKSFWKEAACNA----VFAGLNTLVSYVGPYLISYF---------- 331

  Fly   131 IDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNAT 195
                    .|.|.                      |..:||..
plant   332 --------VDYLG----------------------GKEIFPHE---------------------- 344

  Fly   196 AVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQ-----RLMGARMRIACCSLIYRK 255
                                |.||. ...|...|:..|..||     .::|..:|.|..:::|||
plant   345 --------------------GYVLA-GIFFTSKLIETVTTRQWYMGVDILGMHVRSALTAMVYRK 388

  Fly   256 TLRLSMKTAGQTPAGYLINLLSNDVNRL-DYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGV 319
            .|:||........:|.::|.::.||.|: ||.: ::|.||::|:|.:|...:::.::||.|:..:
plant   389 GLKLSSIAKQNHTSGEIVNYMAVDVQRIGDYSW-YLHDIWMLPMQIVLALAILYKSVGIAAVATL 452

  Fly   320 VGL---LLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEA 381
            |..   :|.|:|    |:||....:.::....|.|:...:|.::.::|:|:.|||..::..:.|.
plant   453 VATIISILVTIP----LAKVQEDYQDKLMTAKDERMRKTSECLRNMRVLKLQAWEDRYRVRLEEM 513

  Fly   382 RRSEIKQIRYASYLRGF----YLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQL 442
            |..|...:|.|.|.:.|    :.|:.:|...    :|.|.:..:|..:||..|.||.:.:.|||.
plant   514 REEEYGWLRKALYSQAFVTFIFWSSPIFVAA----VTFATSIFLGTQLTAGGVLSALATFRILQE 574

  Fly   443 VAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINASWDIE 507
            .... :|..||..|:..|||.||..||..|..:|....:..:    |..:.|:.|||....||..
plant   575 PLRN-FPDLVSMMAQTKVSLDRISGFLQEEELQEDATVVIPR----GLSNIAIEIKDGVFCWDPF 634

  Fly   508 KPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTG 572
            ..:.||..|.:::|||...||.|.||:||||.:..:|||:|.|.|.|.|.|...|.:|..|:.:|
plant   635 SSRPTLSGIQMKVEKGMRVAVCGTVGSGKSSFISCILGEIPKISGEVRICGTTGYVSQSAWIQSG 699

  Fly   573 SVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKP 637
            ::..|||||...::.:|:.|.:.|:|..|.:...:||:|::||||.:|||||:.|:.||||:|:.
plant   700 NIEENILFGSPMEKTKYKNVIQACSLKKDIELFSHGDQTIIGERGINLSGGQKQRVQLARALYQD 764

  Fly   638 AQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQL-KATRILVTHQVHFLSEADVIVIVDQGRIL 701
            |.|||:|||.||:|||.|..||.:.|     |:.| :.|.:.|||||.||..||:|:::.:|||:
plant   765 ADIYLLDDPFSALDAHTGSDLFRDYI-----LSALAEKTVVFVTHQVEFLPAADLILVLKEGRII 824

  Fly   702 RQGTYQELINSDLDFARL------------LERPKEEEEGENS-------RNQTSPLSVNSLESD 747
            :.|.|.:|:.:..||..|            :..|..|:..||.       .|..|.:..|.:|:.
plant   825 QSGKYDDLLQAGTDFKALVSAHHEAIEAMDIPSPSSEDSDENPIRDSLVLHNPKSDVFENDIETL 889

  Fly   748 DEDIPFIDGVKDGYQQLRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISPRVWYEYFHAG 812
            .:::. ..|.....:.::::......|:.....|.::.|          .|.:|.:|:..|..|.
plant   890 AKEVQ-EGGSASDLKAIKEKKKKAKRSRKKQLVQEEERV----------KGKVSMKVYLSYMGAA 943

  Fly   813 STLLSFSFMVFVMVMSQVVCSSSDFFANIWTQQEHQRSQG-EATFSTFECMYIYGALIIAVVIMT 876
            ..    ..::.:::::|.........:|.|....:.:::| |:.......:.:|.||.....:..
plant   944 YK----GALIPLIILAQAAFQFLQIASNWWMAWANPQTEGDESKVDPTLLLIVYTALAFGSSVFI 1004

  Fly   877 TFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFI 941
            ..|..|.....:.|::.|...|...:..|.|.|||:||:||||||.|.|...:|..:|..:..|.
plant  1005 FVRAALVATFGLAAAQKLFLNMLRSVFRAPMSFFDSTPAGRILNRVSIDQSVVDLDIPFRLGGFA 1069

  Fly   942 QIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLT 1006
            ...:.:.||:.|:..:...:...::.|||....:.|.|:..|::|.|:..|.:||:......|:.
plant  1070 STTIQLCGIVAVMTNVTWQVFLLVVPVAVACFWMQKYYMASSRELVRIVSIQKSPIIHLFGESIA 1134

  Fly  1007 GLAIIRS-RQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSET 1070
            |.|.||. .|.:..:.:...||.......:....|:.     || |:....|:::.|:|.:....
plant  1135 GAATIRGFGQEKRFIKRNLYLLDCFVRPFFCSIAAIE-----WL-CLRMELLSTLVFAFCMVLLV 1193

  Fly  1071 TY-SGNV-----GLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQE-PALGEK-TP 1127
            :: .|.:     |||:...:.|.|.:...:....:...::.|:||:.||:::..| ||:.|. .|
plant  1194 SFPHGTIDPSMAGLAVTYGLNLNGRLSRWILSFCKLENKIISIERIYQYSQIVGEAPAIIEDFRP 1258

  Fly  1128 PQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHIE- 1191
            |..||..|.:|..::..||..|...||..::.....|.|:|||||||:|||:||.|||||  ||
plant  1259 PSSWPATGTIELVDVKVRYAENLPTVLHGVSCVFPGGKKIGIVGRTGSGKSTLIQALFRL--IEP 1321

  Fly  1192 --GEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKA 1254
              |:|.||.|:...|.|..||:|:.||||||.||..|||.||||.|.::|.::|.||:..:|...
plant  1322 TAGKITIDNIDISQIGLHDLRSRLGIIPQDPTLFEGTIRANLDPLEEHSDDKIWEALDKSQLGDV 1386

  Fly  1255 IPG----LDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKF 1315
            :.|    ||..|.|.|.|:|||||||:.|.||:|:..|:||||||||:||..||.|||:.||.:|
plant  1387 VRGKDLKLDSPVLENGDNWSVGQRQLVSLGRALLKQAKILVLDEATASVDTATDNLIQKIIRTEF 1451

  Fly  1316 KQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLK-KSQGHLRQMVE----ATG 1369
            :.|||.|:|||:.||:|||.::|:..|...|||.|..||: ||...|:.:.|    :||
plant  1452 EDCTVCTIAHRIPTVIDSDLVLVLSDGRVAEFDTPARLLEDKSSMFLKLVTEYSSRSTG 1510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	426/1394 (31%)
ABCC5	NP_171908.1	MRP_assoc_pro	229..1493	CDD:188098	426/1394 (31%)