DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and ABCC14

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_191829.1	Gene:	ABCC14 / 825444	AraportID:	AT3G62700	Length:	1539	Species:	Arabidopsis thaliana

Alignment Length:	1416	Identity:	436/1416 - (30%)
Similarity:	690/1416 - (48%)	Gaps:	222/1416 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRKKQKPHL 80
            |:.||:..:.|..|||.:|.:..||.|.:.....|.|:|:|....|.:|.|..|.|...     :
plant   253 ASFISKTFWLWMNPLLRKGYKSPLNLDQVPTLSPEHRAEKLATLFESKWPKPQENSRNP-----V 312

  Fly    81 RNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISISDSLNRT 145
            |..|.|||........::..|.:.:..:.| ||.|..:.|
plant   313 RTTLIRCFWKEIAFTAVLAIIRLSVIYVGP-VLIQSFVDF------------------------- 351

  Fly   146 ARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQTVEHMWN 210
                           :||.           ::.|
plant   352 ---------------TSGK-----------RSSP------------------------------- 359

  Fly   211 DMNSLGAVLVLSTLFCCFL----LHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKTAGQTPAGY 271
               |.|..|||..|...|:    .|..:...:.:|..:|....:.:|:|.|:|:.........|.
plant   360 ---SQGYYLVLILLIAKFVEVLSTHQFNFNSQKLGMLIRSTLITALYKKGLKLTGSARQNHGVGQ 421

  Fly   272 LINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGL-------LLKTVPV 329
            ::|.::.|..:|....:.:|.||:||||......|::..:|...:..|:||       ||.|
plant   422 IVNYMAVDAQQLSDMMLQLHAIWLMPLQVAAAIVLLYNTLGPSVVTTVIGLTGIFVFILLGT--- 483

  Fly   330 QTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASY 394
                 |..:..:..:....|:|:...||::..::|||..|||..|...:.:.|..|...:  :.:
plant   484 -----KRNNRYQFSLMMNRDSRMKATNEMLNYMRVIKFQAWEDHFNERILKFREMEFGWL--SKF 541

  Fly   395 LRGFYLSTMVFTERSTLY--ITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAE 457
            |.....:.:|......|.  :|...|..:|..:.|..||:..:.:.|||..... :|.::...::
plant   542 LYSIAGNIIVLWSTPVLISALTFTTAVFLGVKLDAGTVFTTTTIFKILQEPIRT-FPQSMISLSQ 605

  Fly   458 ALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINASWDIEKPQKTLQSINLQIEK 522
            |::||.|:..::|.....|.|.    :|.|....:.||.|||.:.|||.|..:..:::||.:::|
plant   606 AMISLGRLDAYMMSRELSEETV----ERSQGCDGNVAVEIKDGSFSWDDEDDEPAIENINFEVKK 666

  Fly   523 GQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRK 587
            |:|.|::|.||:||||:|..:|||:..:.|.|.:.|..:|.||..|:..|:|::|||||...:|.
plant   667 GELAAIVGTVGSGKSSLLASVLGEMHKLSGKVRVCGTTAYVAQTSWIQNGTVQDNILFGLPMNRS 731

  Fly   588 RYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDA 652
            :|.||.:.|.|..|.|.:..||:|.:||||.:|||||:.||.||||||:.:.:||:||..|||||
plant   732 KYNEVLKVCCLEKDMQIMEFGDQTEIGERGINLSGGQKQRIQLARAVYQESDVYLLDDVFSAVDA 796

  Fly   653 HVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFA 717
            |.|..:|.:.:  ||.|.  ..|.:||||||.||...|.|:::..|.|::.|.|.||::|.|||.
plant   797 HTGSDIFKKCV--RGALK--GKTILLVTHQVDFLHNVDRILVMRDGMIVQSGKYDELVSSGLDFG 857

  Fly   718 RLLERPKEE----EEGENSRN-----QTSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVHG 773
            .|:...:..    |.|..|..     ..||::..|:..:....|              :|..||.
plant   858 ELVAAHETSMELVEAGSASATAANVPMASPITQRSISIESPRQP--------------KSPKVHR 908

  Fly   774 SKSLDS--------------TQLDD---------NVDEDD----LAEAQASGGISPRVWYEYFHA 811
            :.|::|              ::|:|         |:.||.    ..|.:..|.:|.:|:..|...
plant   909 TTSMESPRVLRTTSMESPRLSELNDESIKSFLGSNIPEDGSRLIKEEEREVGQVSFQVYKLYSTE 973

  Fly   812 GSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQQEHQRSQGEATFSTFECMYIYGALIIAVVIMT 876
            .........:||..|..|....:||:    |...| ..::.|.:|.....:.:|..:....:::.
plant   974 AYGWWGMILVVFFSVAWQASLMASDY----WLAYE-TSAKNEVSFDATVFIRVYVIIAAVSIVLV 1033

  Fly   877 TFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFI 941
            ..|.|....:.:..:::...::...::||.|.|||||||||||:|.|.|...:|..:|      .
plant  1034 CLRAFYVTHLGLKTAQIFFKQILNSLVHAPMSFFDTTPSGRILSRASTDQTNVDIFIP------F 1092

  Fly   942 QIALV--MFGILIVIGILN-----PVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFS 999
            .|.||  |:..|:.|.|:.     |. |..::.:..:::.....||..|::|.||:.|.::||..
plant  1093 MIGLVATMYTTLLSIFIVTCQYAWPT-VFFIIPLGWLNIWYRGYYLASSRELTRLDSITKAPVIH 1156

  Fly  1000 HLSASLTGLAIIRSRQLQDVVAKE------FDLLQDVH---SSVW---QLTMAVNTTLGLWLDCV 1052
            |.|.|:.|:..||:.:.|.:..:|      .:|..|.|   |:.|   :|.:     :|.|:.|:
plant  1157 HFSESIAGVMTIRAFKKQPMFRQENVKRVNANLRMDFHNNGSNEWLGFRLEL-----IGSWVLCI 1216

  Fly  1053 SCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELE 1117
            |.:|:..:. |.||..|     ||||:::..:.|.|::.:.:........:|.||||:.|:|::.
plant  1217 SALFMVMLP-SNIIKPE-----NVGLSLSYGLSLNGVLFWAIYLSCFIENKMVSVERIKQFTDIP 1275

  Fly  1118 QEP--ALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSL 1180
            .|.  .:.|..||..||.:|.:...::..||.||...||:.|.:.|:.|.|:|:|||||:|||:|
plant  1276 AEAKWEIKESRPPPNWPYKGNIRLEDVKVRYRPNTPLVLKGLTIDIKGGEKIGVVGRTGSGKSTL 1340

  Fly  1181 IGALFRLAHIE-GEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWS 1244
            |..||||.... |:|.||||:..|:.|..||:|..||||:||||..|:|.|:||.|:|:|.|:|.
plant  1341 IQVLFRLVEPSGGKIIIDGIDICTLGLHDLRSRFGIIPQEPVLFEGTVRSNIDPTEKYSDEEIWK 1405

  Fly  1245 ALEDVELRKAIPG----LDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDA 1305
            :||..:|:..:..    ||.:|.:.|.|:||||||||||.|.:|:.:::|.||||||:||.||||
plant  1406 SLERCQLKDVVASKPEKLDSLVADNGENWSVGQRQLLCLGRVMLKRSRILFLDEATASVDSQTDA 1470

  Fly  1306 LIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKK 1356
            :||:.||..|..||::::|||:.||||.||::|:|||.|.|:|.|..||::
plant  1471 MIQKIIREDFSDCTIISIAHRIPTVMDCDRVLVIDAGKAKEYDSPVRLLER 1521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	436/1416 (31%)
		ABC_membrane	214..441	CDD:294371	57/239 (24%)
		ABCC_MRP_domain1	495..699	CDD:213217	93/203 (46%)
		ABC_membrane	863..1088	CDD:294371	68/243 (28%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	111/219 (51%)
ABCC14	NP_191829.1	MRP_assoc_pro	142..1534	CDD:188098	436/1416 (31%)
		ABC_membrane	329..593	CDD:294371	68/359 (19%)
		ABCC_MRP_domain1	639..838	CDD:213217	93/202 (46%)
		ABC_membrane	984..1252	CDD:294371	79/290 (27%)
		ABCC_MRP_domain2	1295..1515	CDD:213211	111/219 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720