DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and ABCC9

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_191575.2	Gene:	ABCC9 / 825186	AraportID:	AT3G60160	Length:	1506	Species:	Arabidopsis thaliana

Alignment Length:	1386	Identity:	413/1386 - (29%)
Similarity:	678/1386 - (48%)	Gaps:	161/1386 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 NPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRKK 75
            :|..:|.:..::.|:|..||...|.:|.|..||:.....:|.:     |.....|.:..::.::|
plant   235 SPYGNATLFQRITFSWINPLFSLGYKRPLEKDDVPDIDVKDSA-----RFCSHAFDQKLKTTKEK 294

  Fly    76 QKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISISD 140
            :.|  .||.|        .|.::.:::  .|..|.||.|
plant   295 EGP--GNAFF--------YNSVLRYVW--RKAAINAVFA-------------------------- 321

  Fly   141 SLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQTV 205
            .:|.:...|..|:::..|...|.....:|....|...|.|              ||  .|::...
plant   322 VVNASTAYIGPYLINDFVEFLSEKQSQSLNHGYLLALGFL--------------TA--KIVETVT 370

  Fly   206 EHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKTAGQTPAG 270
            :..|    ..||                    |.:|.|:|.|..|.||:|.|.||.::.....:|
plant   371 QRQW----IFGA--------------------RQLGLRLRAALISHIYQKGLVLSSQSRQSHTSG 411

  Fly   271 YLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTALSK 335
            .:||.:|.||.|:.....:::.||::|:|.....|::..::|:.|:..:|..|: .:.....|::
plant   412 EIINYMSVDVQRITDFIWYVNNIWMLPIQIFSAIYILQKHLGLGALAALVTTLM-VMACNYPLTR 475

  Fly   336 VTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRGFYL 400
            :....:..|....|.|:...:|:::.::::|:.||:..|...|...|:.|...:..:..|:.|
plant   476 LQRNYQSDIMNAKDDRMKATSEILKNMKILKLQAWDNQFLNKVKTLRKKEYDCLWKSLRLQAF-- 538

  Fly   401 STMVFTERSTL--YITLAAAALMGQTITADFVFSAASYYNILQLVAAIW-YPLAVSFGAEALVSL 462
            :|.:.....:|  .:|.....|||..:||..|.||.:.:.:||  :.|: .|..:|...::.||.
plant   539 TTFILWGAPSLISVVTFVTCMLMGVKLTAGAVLSALATFQMLQ--SPIFGLPDLLSALVQSKVSA 601

  Fly   463 RRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINASWDIEKPQKTLQSINLQIEKGQLCA 527
            .||..:|    ::..||....:...:.....:|.|::...||:.|..:.||..|.|:::.|...|
plant   602 DRIASYL----QQSETQKDAVEYCSKDHTELSVEIENGAFSWEPESSRPTLDDIELKVKSGMKVA 662

  Fly   528 VIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEV 592
            |.|.||:||||:|..:|||:..:.|.|.:.|..:|..|.||:.:|::|:|||||..::.::|:..
plant   663 VCGAVGSGKSSLLSSILGEIQKLKGTVRVSGKQAYVPQSPWILSGTIRDNILFGSMYESEKYERT 727

  Fly   593 TRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRH 657
            .:.|||..||:...|||.|.:||||.::||||:.||.:|||||:.|.|||:|||.||||||.||.
plant   728 VKACALIKDFELFSNGDLTEIGERGINMSGGQKQRIQIARAVYQNADIYLLDDPFSAVDAHTGRE 792

  Fly   658 LFDEVIGPRGRLAQLKATRIL-VTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLE 721
            ||::.:     :..||...:| |||||.||..||:|:::..||:::.|.::||:..::.|..|:.
plant   793 LFEDCL-----MGILKDKTVLYVTHQVEFLPAADLILVMQNGRVMQAGKFEELLKQNIGFEVLVG 852

  Fly   722 RPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDG----YQQLRKQSSSVHGSKSLDSTQL 782
            ...|..:           |:.|:|....:  |.:|.||.    .:.|:....|.| :.|.::.:.
plant   853 AHNEALD-----------SILSIEKSSRN--FKEGSKDDTASIAESLQTHCDSEH-NISTENKKK 903

  Fly   783 DDNVDEDDLAEAQASGGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQQEH 847
            :..:.:|:..|   .|.|...|:..|.......|...|::......|::..:|:::. .||....
plant   904 EAKLVQDEETE---KGVIGKEVYLAYLTTVKGGLLVPFIILAQSCFQMLQIASNYWM-AWTAPPT 964

  Fly   848 QRSQGEATFSTFECMYIYGAL-------IIAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHA 905
            ..|..:....  ..:.:|..|       ::|..|:....|       :..::....||...|..|
plant   965 AESIPKLGMG--RILLVYALLAAGSSLCVLARTILVAIGG-------LSTAETFFSRMLCSIFRA 1020

  Fly   906 TMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIG---ILNPV---LVAA 964
            .|.|||:||:||||||.|.|...:|  |..|    :::....|.|:.::|   :::.|   :...
plant  1021 PMSFFDSTPTGRILNRASTDQSVLD--LEMA----VKLGWCAFSIIQIVGTIFVMSQVAWQVCVI 1079

  Fly   965 MLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQD 1029
            .:.|||..|...:.|...:::|.|:.|:.|:|:..|.:.||.|...||:...:|.......:|.|
plant  1080 FIPVAVACVFYQRYYTPTARELSRMSGVERAPILHHFAESLAGATTIRAFDQRDRFISSNLVLID 1144

  Fly  1030 VHSSVWQLTMAVNTTLGLWLDCVS-CIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYG 1093
            .||..|....:....|...|:.:| .:|..|:.....:..........||.:...:.|..:....
plant  1145 SHSRPWFHVASAMEWLSFRLNLLSHFVFAFSLVLLVTLPEGVINPSIAGLGVTYGLSLNVLQATV 1209

  Fly  1094 VRQVAESLQQMTSVERVLQYTELEQEPAL---GEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLR 1155
            :..:..:..:|.||||:|||:::..|..|   |.: |...||..|.:.||::..||..:...||:
plant  1210 IWNICNAENKMISVERILQYSKIPSEAPLVIDGHR-PLDNWPNVGSIVFRDLQVRYAEHFPAVLK 1273

  Fly  1156 NLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-IEGEIFIDGIETGTISLEILRTRISIIPQD 1219
            |:......|.|:|:|||||:|||:||.||||:.. .:|.|.||.::...|.|..||:|:.|||||
plant  1274 NITCEFPGGKKIGVVGRTGSGKSTLIQALFRIVEPSQGTIVIDNVDITKIGLHDLRSRLGIIPQD 1338

  Fly  1220 PVLFSATIRYNLDPFERYTDAELWSALEDVELRKAIPG----LDYMVTERGGNFSVGQRQLLCLA 1280
            |.||..|||.||||..:|||.|:|.|::..:|...|..    ||..|.|.|.|:|||||||:||.
plant  1339 PALFDGTIRLNLDPLAQYTDHEIWEAIDKCQLGDVIRAKDERLDATVVENGENWSVGQRQLVCLG 1403

  Fly  1281 RAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAV 1345
            |.:|:.:.:||||||||:||..||.:||:.|..:||..||:|:|||:|||::||.::|:..|...
plant  1404 RVLLKKSNILVLDEATASVDSATDGVIQKIINQEFKDRTVVTIAHRIHTVIESDLVLVLSDGRIA 1468

  Fly  1346 EFDVPYLLLKKSQGHLRQMVE 1366
            |||.|..||::......::::
plant  1469 EFDSPAKLLQREDSFFSKLIK 1489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	413/1386 (30%)
		ABC_membrane	214..441	CDD:294371	55/228 (24%)
		ABCC_MRP_domain1	495..699	CDD:213217	92/204 (45%)
		ABC_membrane	863..1088	CDD:294371	60/238 (25%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	107/219 (49%)
ABCC9	NP_191575.2	PLN03232	68..1488	CDD:215640	413/1383 (30%)
		ABC_membrane	319..586	CDD:294371	73/337 (22%)
		ABCC_MRP_domain1	630..830	CDD:213217	92/204 (45%)
		ABC_membrane	973..1209	CDD:294371	60/250 (24%)
		ABCC_MRP_domain2	1253..1473	CDD:213211	107/219 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720