Protein Alignment Cftr and ABCC10

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_191473.2
• Gene: ABCC10 / 825083
• AraportID: AT3G59140
• Length: 1453
• Species: Arabidopsis thaliana
• Alignment Length: 1389
• Identity: 412/1389 - (29%)
• Similarity: 668/1389 - (48%)
• Gaps: 195/1389 - (14%)

  Fly    16 ANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRKKQKPHL 80
            |.:.|.|.|.|...|:.||:.:.|..:|:.:..||:|:|......|:...::..|.....| |.:
plant   210 AGLFSTLSFWWLNSLIKRGNVKDLEEEDIPELRKEERAETCYSLFEENLIEQKRRLGSSCQ-PSI 273

  Fly    81 RNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISISDSLNRT 145
            ......|.....:.:|...|:.||..:..|.:|...::      ||:
plant   274 LKVTVLCVWRELLTSGFFAFMKIVAVSAGPLLLNAFIL------VAE------------------ 314

  Fly   146 ARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQTVEHMWN 210
                                |:|.|...
plant   315 --------------------GNASFRYE------------------------------------- 322

  Fly   211 DMNSLGAVLVLSTLFCCFLLHHVDLRQ-----RLMGARMRIACCSLIYRKTLRLSMKTAGQTPAG 270
                 |.||.: .||...::..:..||     |::|.|:|....:.|.:|.|||:..:.......
plant   323 -----GLVLAV-LLFFSKMIESLSQRQWYFRCRIVGLRVRSLLTAAINKKQLRLNNSSRLIHSGS 381

  Fly   271 YLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTALSK 335
            .::|..:.|..|:.....:.|.:|....|.::...:::.::|: |....:.:::.||.....::|
plant   382 EIMNYATVDAYRIGEFPYWFHQLWTTSFQLLIALGILFHSVGV-ATFSALAVIILTVLCNAPIAK 445

  Fly   336 VTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRGF-- 398
            :.:..:..:....|.|:...||.:..::|:|:||||..|:.|:.:.|..|:|.::.....:.:
plant   446 LQNKFQSELMTSQDERLKACNESLVNMKVLKLYAWESHFKKVIEKLRNIELKSLKAVQMRKAYNA 510

  Fly   399 --YLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVS 461
              :.|:.||...:    |.|....:...:.|..||:..:...::|....: .|..:....:|.|:
plant   511 VLFWSSPVFVSAA----TFATCYFLDIPLRASNVFTFVATLRLVQDPVRM-IPDVIGVTIQAKVA 570

  Fly   462 LRRIQDFL---MLEGREERTQGLTHKRDQEGGDSRAVTIKDINASWDIEKPQK-TLQSINLQIEK 522
            ..||..||   .|:|.|.|      ::.:..|:..|:.||..:.||:.:...| .|::::|:::.
plant   571 FSRIATFLEAPELQGGERR------RKQRSEGNQNAIIIKSASFSWEEKGSTKPNLRNVSLEVKF 629

  Fly   523 GQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRK 587
            |:..||.|.||:|||::|..:|||.|.:.|.:...|.::|.:|..|:.||::|:|||||...|..
plant   630 GEKVAVCGEVGSGKSTLLAAILGETPCVSGTIDFYGTIAYVSQTAWIQTGTIRDNILFGGVMDEH 694

  Fly   588 RYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDA 652
            ||:|..:..:|..|.:.||:||:|.:||||.:|||||:.||.||||:|:.|.|||:|||.|||||
plant   695 RYRETIQKSSLDKDLELLPDGDQTEIGERGVNLSGGQKQRIQLARALYQDADIYLLDDPFSAVDA 759

  Fly   653 HVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFA 717
            |....||.|.:  ...||. ||. :||||||.||...|.::::..|.|....|||||:....||.
plant   760 HTASSLFQEYV--MDALAG-KAV-LLVTHQVDFLPAFDSVLLMSDGEITEADTYQELLARSRDFQ 820

  Fly   718 RLLERPKEEEEGEN---SRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSLDS 779
            .|:...:|....|.   ..|.|.|                  ||:..:.:..||..:..|:.:..
plant   821 DLVNAHRETAGSERVVAVENPTKP------------------VKEINRVISSQSKVLKPSRLIKQ 867

  Fly   780 TQLDDNVDEDDLAEAQASGGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQ 844
                         |.:..|....|.:.:|.:.....:.|    |:..::||..:......|.|..
plant   868 -------------EEREKGDTGLRPYIQYMNQNKGYIFF----FIASLAQVTFAVGQILQNSWMA 915

  Fly   845 QEHQRSQGEATFSTFECMYIYGALIIAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRF 909
            ......|    .||.:.:.:|..:.:..|:....|......:||.:|..|..::...:..|.|.|
plant   916 ANVDNPQ----VSTLKLILVYLLIGLCSVLCLMVRSVCVVIMCMKSSASLFSQLLNSLFRAPMSF 976

  Fly   910 FDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVI----------GILNPVLVAA 964
            :|:||.||||:|.|.|:..:|..:|             ||::.|:          |:| .::...
plant   977 YDSTPLGRILSRVSSDLSIVDLDVP-------------FGLIFVVASSVNTGCSLGVL-AIVTWQ 1027

  Fly   965 MLVVAVVDVLIL----KLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFD 1025
            :|.|:|..|.:.    |.|.:.:::|.|:.|..||.|.:||:.|:.|...||:...::...|:..
plant  1028 VLFVSVPMVYLAFRLQKYYFQTAKELMRINGTTRSYVANHLAESVAGAITIRAFDEEERFFKKSL 1092

  Fly  1026 LLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTY-SGNVGLAIAQAMILTGM 1089
            .|.|.::|.:..:.|.|..|...|:.||.|.|.|..|..|:....|: ||.:|:|::..:.|...
plant  1093 TLIDTNASPFFHSFAANEWLIQRLETVSAIVLASTAFCMILLPTGTFSSGFIGMALSYGLSLNMG 1157

  Fly  1090 VQYGVRQVAESLQQMTSVERVLQYTELEQE-PALGEKT-PPQQWPTRGQVEFRNMSCRYDPNGSP 1152
            :.|.|:........:.||||:.|||.|..| |.:.|:| ||..||..|:||..::..||......
plant  1158 LVYSVQNQCYLANWIISVERLNQYTHLTPEAPEVIEETRPPVNWPVTGRVEISDLQIRYRRESPL 1222

  Fly  1153 VLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-IEGEIFIDGIETGTISLEILRTRISII 1216
            ||:.::.|.|.|.|:|||||||:||::||.|||||.. :.|:|.:||::...|.:..||:|..||
plant  1223 VLKGISCTFEGGHKIGIVGRTGSGKTTLISALFRLVEPVGGKIVVDGVDISKIGVHDLRSRFGII 1287

  Fly  1217 PQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAIP----GLDYMVTERGGNFSVGQRQLL 1277
            ||||.||:.|:|:||||..:::|||:|..|...:|::.:.    |||.:|.|.|.|:|:|||||.
plant  1288 PQDPTLFNGTVRFNLDPLCQHSDAEIWEVLGKCQLKEVVQEKENGLDSLVVEDGSNWSMGQRQLF 1352

  Fly  1278 CLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAG 1342
            ||.||:||.::|||||||||::|..||.::|:|||.:|..|||:|||||:.||||...::.:..|
plant  1353 CLGRAVLRRSRVLVLDEATASIDNATDLILQKTIRREFADCTVITVAHRIPTVMDCTMVLSISDG 1417

  Fly  1343 VAVEFDVPYLLLKKSQGHLRQMVE 1366
            ..||:|.|..|:|.......::|:
plant  1418 RIVEYDEPMKLMKDENSLFGKLVK 1441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	410/1377 (30%)
ABCC10	NP_191473.2	MRP_assoc_pro	194..1437	CDD:188098	411/1383 (30%)