Protein Alignment Cftr and ABCC8

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_001326629.1
• Gene: ABCC8 / 821679
• AraportID: AT3G21250
• Length: 1470
• Species: Arabidopsis thaliana
• Alignment Length: 1424
• Identity: 425/1424 - (29%)
• Similarity: 668/1424 - (46%)
• Gaps: 211/1424 - (14%)

  Fly    10 KNPRQH------ANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKEL 68
            ||||:.      |...|.|.|:|..|||..|.::.|:.:|:...:.||.::....:....|...|
plant   200 KNPRKESARLATAGFFSILSFSWMNPLLSLGFKKPLSPEDIPSVVPEDEAQLAYKKFSQAWDTLL 264

  Fly    69 ERSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDV 133
            ......|:    ||.:||..:.......:...::..::|.....|..:|..|          :|
plant   265 GDESSTKE----RNLVFRAVVKVYFKENIFIAVFAFLRTFAVVSLPLMLYVF----------VD- 314

  Fly   134 NDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVR 198
                                    .|||                             ||
plant   315 ------------------------YANS-----------------------------DH------ 320

  Fly   199 SILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKT 263
                   ..:.|...:| |.||:..|.....:.|.....|..|.|:|.|.....|:|.|:||...
plant   321 -------RDLRNGFFNL-ACLVMLKLVESLTMRHWYFASRRSGMRIRSALMVAAYKKQLKLSSLG 377

  Fly   264 AGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLL---LK 325
            ..:..:|.::|.::.|..|:.....:.|..|.:.||.:|:..:::..:|..|..|::.||   |.
plant   378 RKRHSSGEIVNYIAVDAYRMGEFLWWFHSGWSLSLQLLLSTAVLFGVVGAGAFPGLILLLLCGLL 442

  Fly   326 TVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIR 390
            .:|....|....:  :..||:  |.|:...:|::..::|||:.:||..|:..:...|..|...:.
plant   443 NLPFAKMLQNCQT--QFMIAQ--DKRLRSTSEILNSMKVIKLQSWEDEFKKKIESCRDDEFTWLA 503

  Fly   391 YASYLRGF--YLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVS 453
            .|...:.|  :|..|..|..|:: :.|..|.|....:.|..:|:..:...::.....| .|.|:|
plant   504 KAQLTKAFGSFLYWMSPTIVSSV-VFLGCALLKSAPLNASTIFTVLATLRVMSEPVKI-IPDAIS 566

  Fly   454 FGAEALVSLRRIQDFLM---LEGREERTQGLTHKRDQEGGDSRAVTIKDINASWDIEKPQKTLQS 515
            ...:..||.:|:.:||:   |:..|....||    |..|   .||.|:..|..|:.|....||::
plant   567 AIIQGNVSFQRLNNFLLDDELKMDEIERSGL----DASG---TAVDIQVGNFGWEPETKIPTLRN 624

  Fly   516 INLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILF 580
            |:|:|:.||..||.|||||||||:|..:|||:|.:.|.|.:.|.::|.:|..|:.:|::|:|||:
plant   625 IHLEIKHGQKVAVCGPVGAGKSSLLHAVLGEIPKVSGTVKVFGSIAYVSQTSWIQSGTIRDNILY 689

  Fly   581 GEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDD 645
            |:..:.:||....:.|||..|.....:||.|.:|:||.:|||||:.||.||||||..|.:||:||
plant   690 GKPMESRRYNAAIKACALDKDMNGFGHGDLTEIGQRGINLSGGQKQRIQLARAVYADADVYLLDD 754

  Fly   646 PLSAVDAHVGRHLFDEVIGPRGRLAQLK-ATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQEL 709
            |.||||||....||.:.:..     .|| .|.|||||||.||||.|.|:::::|.|.:.|.|:||
plant   755 PFSAVDAHTAGVLFHKCVED-----SLKEKTVILVTHQVEFLSEVDQILVMEEGTITQSGKYEEL 814

  Fly   710 INSDLDFARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVHGS 774
            :.....|.:|:       ...|......||:.|....|                |||:.......
plant   815 LMMGTAFQQLV-------NAHNDAVTVLPLASNESLGD----------------LRKEGKDREIR 856

  Fly   775 KSLDSTQLDDNVDEDDL-------AEAQASG--GISPRVWYEYFHAGSTLLSFSFMVFVMVMSQV 830
            ......::::.:::.|:       .|.:.||  |:.|.:.|.....|..||..|.:
plant   857 NMTVVEKIEEEIEKTDIPGVQLTQEEEKESGYVGMKPFLDYIGVSRGWCLLWSSVL--------- 912

  Fly   831 VCSSSDFFANIWTQQEHQRSQGEATFSTFECMYIY------------GALIIAV--VIMTTFRGF 881
                                 |:..|..|:....|            ..::|.|  :|.|...||
plant   913 ---------------------GQVGFVVFQAASTYWLAFAIGIPKITNTMLIGVYSIISTLSAGF 956

  Fly   882 LFFK------ICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDF 940
            ::.:      :.:.|||.........:..|.|.|||:||.||||.|.|.|:..:|..:|.|.:..
plant   957 VYARAITTAHLGLKASKAFFSGFTNAVFKAPMLFFDSTPVGRILTRASSDLNVLDYDVPFAFIFV 1021

  Fly   941 IQIALVMFGILIVIGILN-PVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSAS 1004
            :..|:.:...|:::..:. .|::.|:|.:|...| :...||..:::|.|:.|..::||.::.:.:
plant  1022 VAPAVELTAALLIMTYVTWQVIIIALLALAATKV-VQDYYLASARELIRINGTTKAPVMNYAAET 1085

  Fly  1005 LTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFL-TSVTFSFIISS 1068
            ..|:..||:....:...|.:..|.|..:.::.|:.|....:.|.::.:..:.| |......:|..
plant  1086 SLGVVTIRAFGTAERFFKNYLNLVDADAVLFFLSNAAMEWVILRIETLQNVTLFTCALLLILIPK 1150

  Fly  1069 ETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQEP--ALGEKTPPQQW 1131
            .....|.|||:::.|:.||....:..|........:.||||:.||..:.:||  .:.:|.||..|
plant  1151 GYIAPGLVGLSLSYALTLTQTQVFLTRWYCTLSNSIISVERIKQYMNIPEEPPAIIDDKRPPSSW 1215

  Fly  1132 PTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-IEGEIF 1195
            |:.|.:..:.:..||.||...||:.::.|...|.:||:|||||:|||:||.|||||.. ..|.|.
plant  1216 PSNGTIHLQELKIRYRPNAPLVLKGISCTFREGTRVGVVGRTGSGKSTLISALFRLVEPASGCIL 1280

  Fly  1196 IDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAIPG--- 1257
            ||||:...|.|:.||.::|||||:|.||...||.||||...|:|.|:|.|||..:|:..|..
plant  1281 IDGIDISKIGLKDLRMKLSIIPQEPTLFRGCIRTNLDPLGVYSDDEIWKALEKCQLKTTISNLPN 1345

  Fly  1258 -LDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVL 1321
             ||..|::.|.|:|||||||.||.|.:|:.||:||||||||::|..|||:|||.||.:|..|||:
plant  1346 KLDSSVSDEGENWSVGQRQLFCLGRVLLKRNKILVLDEATASIDSATDAIIQRIIREEFADCTVI 1410

  Fly  1322 TVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVE----ATGGESEALK 1376
            |||||:.||:|||.::|:..|..||::.|..|::......:.:.|    ..|..|:.|:
plant  1411 TVAHRVPTVIDSDMVMVLSFGDLVEYNEPSKLMETDSYFSKLVAEYWASCRGNSSQNLQ 1469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	419/1396 (30%)
ABCC8	NP_001326629.1	MRP_assoc_pro	193..1449	CDD:188098	421/1402 (30%)