DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and ABCC7

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_187917.3	Gene:	ABCC7 / 820498	AraportID:	AT3G13100	Length:	1493	Species:	Arabidopsis thaliana

Alignment Length:	1420	Identity:	442/1420 - (31%)
Similarity:	680/1420 - (47%)	Gaps:	213/1420 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQL----GDRLEDQWFKELERSH 72
            |..:|..:|.:.|:|..||:..|:.:.::::|:.|....||:|:|    ..:||  |    :...
plant   231 PFSNAGFLSHVSFSWMSPLIVLGNEKIIDSEDVPQVDNSDRAEKLFWIFRSKLE--W----DDGE 289

  Fly    73 RKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDIS 137
            |:.....|..|||.......:::.|..|:|.|...:.|
plant   290 RRITTYKLIKALFFSVWRDILLSTLFAFVYTVSCYVAP--------------------------- 327

  Fly   138 ISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILD 202
                          |::...|...:|.
plant   328 --------------YLMDTFVQYLNGQ-------------------------------------- 340

  Fly   203 QTVEHMWNDMNSLGAVLVLSTLFC-----CFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMK 262
                   ...::.|.||| :|.|.     |....:...|.:..|..||....|:||.|.|.|...
plant   341 -------RQYSNQGVVLV-TTFFVAKLVECQARRNWYFRLQKAGIGMRSVLVSMIYEKGLTLPCY 397

  Fly   263 TAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVG---LLL 324
            :.....:|.:|||::.|..|:.....:||..||:.||..|...:::.::|:.:|.....   ::|
plant   398 SKQGHTSGEIINLMTVDAERISAFSWYMHDPWILVLQISLALLILYRSLGLGSIAAFAATFLVML 462

  Fly   325 KTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQI 389
            ..:|    |:|:....:..:.|..|.|:...:|.:..::::|:..||..|...:.:.|..|
plant   463 GNIP----LAKLEEKFQGNLMESKDNRMKKTSEALLNMRILKLQGWEMKFLHKILDLRGIE---- 519

  Fly   390 RYASYLRGFY-----LSTMVFTERSTLYIT-LAAAALMGQTITADFVFSAASYYNILQLVAAIW- 447
              |.:|:.|.     :|::::...|.:..| ..|..|:...:.:..:.:|.:.:.|||  ..|:
plant   520 --AGWLKKFVYNSAAISSVLWAAPSFVSATAFGACMLLKIPLESGKIIAALATFRILQ--TPIYK 580

  Fly   448 YPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINASWDIEKPQKT 512
            .|..:|...:..|||.||..||.|:..::  .|:  :|...|.....|.:.:...|||...|..|
plant   581 LPDTISMIVQTKVSLDRIATFLCLDDLQQ--DGM--ERLPSGSSKMDVEVSNGAFSWDDSSPIPT 641

  Fly   513 LQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNN 577
            |:.|..:|..|...|:.|.||:||||:|..:|||:|.|.|.:.:.|..:|.||.||:.:|.|..|
plant   642 LKDIRFKIPHGMNIAICGTVGSGKSSLLSSILGEVPKISGNLKVCGRKAYIAQSPWIQSGKVEEN 706

  Fly   578 ILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYL 642
            ||||:...|:.||.|...|:|:.|.:..|..|:|::||||.:|||||:.||.:|||:|:.|.|||
plant   707 ILFGKPMQREWYQRVLEACSLNKDLEVFPFRDQTVIGERGINLSGGQKQRIQIARALYQDADIYL 771

  Fly   643 MDDPLSAVDAHVGRHLFDEVIGPRGRLAQLK-ATRILVTHQVHFLSEADVIVIVDQGRILRQGTY 706
            .|||.||||||.|.|||.||:     |..|: .|.|.||||:.||.|||:|:::..|||.:.|.|
plant   772 FDDPFSAVDAHTGSHLFKEVL-----LGLLRNKTVIYVTHQLEFLPEADLILVMKDGRITQAGKY 831

  Fly   707 QELINSDLDFARL-------LERPKEEEEGENSRNQT----SPLSVNSLESDDEDIPFIDGVKDG 760
            .|::.|..||..|       |......|:|..|...|    |.:| |..|..:||:|...|
plant   832 NEILESGTDFMELVGAHTDALAAVDSYEKGSASAQSTTSKESKVS-NDEEKQEEDLPSPKG---- 891

  Fly   761 YQQLRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISPRVWYEYFHA--GSTLLSFSFMVF 823
              ||.::                         |.:..|.:...|:.:|...  |..|:  ..::.
plant   892 --QLVQE-------------------------EEREKGKVGFTVYQKYMKLAYGGALV--PIILV 927

  Fly   824 VMVMSQVVCSSSDFFANIWTQQEHQRSQGEATFSTFECMYIYGA-----LIIAVVIMTTFRGFLF 883
            |.::.||:...|:::. .|.....:..:...:.||...:|::.|     .|:...:::...|
plant   928 VQILFQVLNIGSNYWM-AWVTPVSKDVKPLVSGSTLILVYVFLATASSFCILVRAMLSAMTG--- 988

  Fly   884 FKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMF 948
            |||.......:|.|:|    .|:|.|||.||.||||||.|.|..|:|..||   ..|..:|:...
plant   989 FKIATELFNQMHFRIF----RASMSFFDATPIGRILNRASTDQSAVDLRLP---SQFSNLAIAAV 1046

  Fly   949 GILIVIGILNPVLVAAMLVVAVVDVLIL-----KLYLRPSQDLKRLEGICRSPVFSHLSASLTGL 1008
            .||.:||::..  ||..:::..:.|:..     :.|:..:::|.||.||.|||:..|.|.:|:|:
plant  1047 NILGIIGVMGQ--VAWQVLIVFIPVIAACTWYRQYYISAARELARLSGISRSPLVQHFSETLSGI 1109

  Fly  1009 AIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCI-FLTSVTFSFIISSETTY 1072
            ..|||...:.....:...|.|.:|.:....::....|...||.:|.: |..|:.....:......
plant  1110 TTIRSFDQEPRFRTDIMRLNDCYSRLRFHAISAMEWLCFRLDLLSTVAFALSLVILVSVPEGVIN 1174

  Fly  1073 SGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQEPALG-EKTPPQQ-WPTRG 1135
            ....|||:..|:.|..:....:..:.:...:|.||||:|||.::..||:|. |.|.|:: ||.||
plant  1175 PSFAGLAVTYALNLNSLQATLIWTLCDLENKMISVERMLQYIDIPSEPSLVIESTRPEKSWPCRG 1239

  Fly  1136 QVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-IEGEIFIDGI 1199
            ::...|:..||.|:...|||.|..|...|.|.|||||||.|||:||..|||:.. ..|||.||||
plant  1240 EITICNLQVRYGPHLPMVLRGLTCTFRGGLKTGIVGRTGCGKSTLIQTLFRIVEPAAGEIRIDGI 1304

  Fly  1200 ETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDV----ELRKAIPGLDY 1260
            ...||.|..||:|:|||||:|.:|..|:|.||||.|.|.|.::|.||:..    |:||....||.
plant  1305 NILTIGLHDLRSRLSIIPQEPTMFEGTVRSNLDPLEEYADDQIWEALDKCQLGDEIRKKELKLDS 1369

  Fly  1261 MVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAH 1325
            .|:|.|.|:|||||||:||.|.:|:.:|||:||||||:||..||.|||.|:|..|..|||:|:||
plant  1370 PVSENGQNWSVGQRQLVCLGRVLLKRSKVLILDEATASVDTATDTLIQETLRQHFSGCTVITIAH 1434

  Fly  1326 RLHTVMDSDRIIVMDAGVAVEFDVPYLLLK-KSQGHLRQMVEATGGESEALKKTA 1379
            |:.:|:|||.::::|.|:..|.|.|..||: ||....:.:.|.|.......|:::
plant  1435 RISSVIDSDMVLLLDQGLIEEHDSPARLLEDKSSSFSKLVAEYTASSDSRFKRSS 1489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	439/1406 (31%)
		ABC_membrane	214..441	CDD:294371	56/240 (23%)
		ABCC_MRP_domain1	495..699	CDD:213217	96/204 (47%)
		ABC_membrane	863..1088	CDD:294371	68/235 (29%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	113/219 (52%)
ABCC7	NP_187917.3	PLN03232	34..1474	CDD:215640	439/1403 (31%)
		ABC_membrane	309..578	CDD:294371	66/367 (18%)
		ABCC_MRP_domain1	624..824	CDD:213217	96/204 (47%)
		ABC_membrane	925..1199	CDD:294371	75/286 (26%)
		ABCC_MRP_domain2	1239..1459	CDD:213211	113/219 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720