Protein Alignment Cftr and ABCC6

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_187916.3
• Gene: ABCC6 / 820497
• AraportID: AT3G13090
• Length: 1466
• Species: Arabidopsis thaliana
• Alignment Length: 1425
• Identity: 452/1425 - (31%)
• Similarity: 687/1425 - (48%)
• Gaps: 227/1425 - (15%)

  Fly    12 PRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQL----GDRLEDQWFKELERSH 72
            |...|.|:|::.|:|..||:..|:.:.::..|:.|..:.|.:|.|    ..:||  |    :...
plant   208 PFSKAGILSRMSFSWMSPLITLGNEKIIDIKDVPQLDRSDTTESLFWIFRSKLE--W----DDGE 266

  Fly    73 RKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDIS 137
            |:.....|..|||.......:::.|:.|:|.|...:.|
plant   267 RRITTFKLIKALFLSVWRDIVLSALLAFVYTVSCYVAP--------------------------- 304

  Fly   138 ISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILD 202
                          |::...|...:|:                                 |...:
plant   305 --------------YLMDNFVQYLNGN---------------------------------RQYKN 322

  Fly   203 QTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQ-----RLMGARMRIACCSLIYRKTLRLSMK 262
            |            |.||| :|.|...|:.....||     :..|..||....|:||.|.|.|...
plant   323 Q------------GYVLV-TTFFVAKLVECQTQRQWFFRGQKAGLGMRSVLVSMIYEKGLTLPCH 374

  Fly   263 TAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTV 327
            :.....:|.:|||::.|.:|:.....|||..||:.||..|..::::.::|:    |.:.....|:
plant   375 SKQGHTSGEIINLMAVDADRISAFSWFMHDPWILVLQVSLALWILYKSLGL----GSIAAFPATI 435

  Fly   328 PVQTA---LSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQI 389
            .|..|   .:|:....:..:.:..|.|:...:|::..::::|:..||..|.:.:.|.|..|
plant   436 LVMLANYPFAKLEEKFQSSLMKSKDNRMKKTSEVLLNMKILKLQGWEMKFLSKILELRHIE---- 496

  Fly   390 RYASYLRGFY-----LSTMVFTERSTLYIT-LAAAALMGQTITADFVFSAASYYNILQLVAAIW- 447
              |.:|:.|.     ::::::...|.:..| ..|..|:...:.:..:.:|.:.:.|||  ..|:
plant   497 --AGWLKKFVYNSSAINSVLWAAPSFISATAFGACLLLKIPLESGKILAALATFRILQ--GPIYK 557

  Fly   448 YPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINASWDIEKPQKT 512
            .|..:|...:..|||.||..||.|:..::...|    |...|....||.|.:...|||...|..|
plant   558 LPETISMIVQTKVSLNRIASFLCLDDLQQDVVG----RLPSGSSEMAVEISNGTFSWDDSSPIPT 618

  Fly   513 LQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNN 577
            |:.:|.::.:|...|:.|.||:||||:|..:|||:|.|.|.:.:.|..:|.||.||:.:|.|..|
plant   619 LRDMNFKVSQGMNVAICGTVGSGKSSLLSSILGEVPKISGNLKVCGRKAYIAQSPWIQSGKVEEN 683

  Fly   578 ILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYL 642
            ||||:..:|:.|..|...|:|:.|.:.||..|:|::||||.:|||||:.||.:|||:|:.|.|||
plant   684 ILFGKPMEREWYDRVLEACSLNKDLEILPFHDQTVIGERGINLSGGQKQRIQIARALYQDADIYL 748

  Fly   643 MDDPLSAVDAHVGRHLFDEVIGPRGRLAQLK-ATRILVTHQVHFLSEADVIVIVDQGRILRQGTY 706
            .|||.||||||.|.|||.||:     |..|: .|.|.|||||.||.|||:|:::..|:|.:.|.|
plant   749 FDDPFSAVDAHTGSHLFKEVL-----LGLLRHKTVIYVTHQVEFLPEADLILVMKDGKITQAGKY 808

  Fly   707 QELINSDLDFARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLR----KQ 767
            .|:::|..||..|:        |.::                |.:..||..:.||...:    |:
plant   809 HEILDSGTDFMELV--------GAHT----------------EALATIDSCETGYASEKSTTDKE 849

  Fly   768 SSSVH-------GSKSLDSTQLDDNVDEDDLAEAQASGGISPRVWYEYF---HAGSTLLSFSFMV 822
            :..:|       ||.:..|.||   |.|    |.:..|.:...|:.:|.   :.|:.:   ..::
plant   850 NEVLHHKEKQENGSDNKPSGQL---VQE----EEREKGKVGFTVYKKYMALAYGGAVI---PLIL 904

  Fly   823 FVMVMSQVVCSSSDFFANIWTQQEHQRSQGEATFSTFECMYIYGALIIAVVIMTTFRGFLF---- 883
            .|.|:.|::...|:::.. |.....:  ..|...|.|..:.:|..|.:|.......|..|.
plant   905 VVQVLFQLLSIGSNYWMT-WVTPVSK--DVEPPVSGFTLILVYVLLAVASSFCILIRALLVAMTG 966

  Fly   884 FKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMF 948
            ||:.......:|.|:|    .|:|.|||.||.||||||.|.|....|..||.   .|..:|:...
plant   967 FKMATELFTQMHLRIF----RASMSFFDATPMGRILNRASTDQSVADLRLPG---QFAYVAIAAI 1024

  Fly   949 GILIVIGILNPVLVAAMLVVAVVDVLIL-----KLYLRPSQDLKRLEGICRSPVFSHLSASLTGL 1008
            .||.:||::  |.||..:::..:.|:..     :.|:..:::|.||.||.||||..|.|.:|:|:
plant  1025 NILGIIGVI--VQVAWQVLIVFIPVVAACAWYRQYYISAARELARLAGISRSPVVHHFSETLSGI 1087

  Fly  1009 AIIRSRQLQDVVAKEFDLLQDVHSSV-WQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTY 1072
            ..|||...:.....:...|.|.:|.: :..|.|:.     || |.....|:  ||:|..|.....
plant  1088 TTIRSFDQEPRFRGDIMRLSDCYSRLKFHSTGAME-----WL-CFRLELLS--TFAFASSLVILV 1144

  Fly  1073 SGN--------VGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQEPALGEKT--P 1127
            |..        .||||..|:.|..:....:..:.:...:|.||||:||||.:..||.|..:|  |
plant  1145 SAPEGVINPSLAGLAITYALNLNTLQATLIWTLCDLENKMISVERMLQYTNIPSEPPLVIETTRP 1209

  Fly  1128 PQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-IE 1191
            .:.||:||::...|:..||.|:...||..|..|...|.|.|||||||.|||:||..|||:.. ..
plant  1210 EKSWPSRGEITICNLQVRYGPHLPMVLHGLTCTFPGGLKTGIVGRTGCGKSTLIQTLFRIVEPAA 1274

  Fly  1192 GEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDV----ELR 1252
            |||.||||...:|.|..||:|:|||||||.:|..|||.||||.|.|||.::|.||::.    |:|
plant  1275 GEIRIDGINILSIGLHDLRSRLSIIPQDPTMFEGTIRSNLDPLEEYTDDQIWEALDNCQLGDEVR 1339

  Fly  1253 KAIPGLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQ 1317
            |....||..|:|.|.|:|||||||:||.|.:|:.:|:||||||||::|..||.|||.|:|..|..
plant  1340 KKELKLDSPVSENGQNWSVGQRQLVCLGRVLLKRSKLLVLDEATASIDTATDNLIQETLRHHFAD 1404

  Fly  1318 CTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEATGGESEALKK 1377
            |||:|:|||:.:|:|||.::::|.|:..|.|.|..||:.......::|......||:..|
plant  1405 CTVITIAHRISSVIDSDMVLLLDQGLIKEHDSPARLLEDRSSLFSKLVAEYTTSSESKSK 1464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	448/1402 (32%)
ABCC6	NP_187916.3	MRP_assoc_pro	190..1449	CDD:188098	448/1408 (32%)