DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and ABCC4

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_182301.1	Gene:	ABCC4 / 819392	AraportID:	AT2G47800	Length:	1516	Species:	Arabidopsis thaliana

Alignment Length:	1411	Identity:	436/1411 - (30%)
Similarity:	690/1411 - (48%)	Gaps:	237/1411 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRKKQKPHL 80
            |::.|:..:.|..|||.:|.:..|..:.:.....|.::|:|....|..|.|..|.|...     :
plant   255 ASVFSKTFWLWMNPLLSKGYKSPLTLEQVPTLSPEHKAERLALLFESSWPKPSENSSHP-----I 314

  Fly    81 RNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISISDSLNRT 145
            |..|.|||....:...::..:.:.:..:.| ||.|..:.|
plant   315 RTTLLRCFWKEILFTAILAIVRLGVMYVGP-VLIQSFVDF------------------------- 353

  Fly   146 ARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQTVEHMWN 210
                           :||.           ::.|                             |.
plant   354 ---------------TSGK-----------RSSP-----------------------------WQ 363

  Fly   211 DMNSLGAVLVLSTLFCCFL----LHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKTAGQTPAGY 271
                 |..|||..|...|:    .|..:...:.:|..:|....:.:|:|.|:|:.........|.
plant   364 -----GYYLVLILLVAKFVEVLTTHQFNFDSQKLGMLIRSTLITALYKKGLKLTGSARQNHGVGQ 423

  Fly   272 LINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGL-------LLKTVPV 329
            ::|.::.|..:|....:.:|.||:||||..:...|::.::|...|..|:||       ||.|
plant   424 IVNYMAVDAQQLSDMMLQLHAIWLMPLQVTVALVLLYGSLGASVITAVIGLTGVFVFILLGT--- 485

  Fly   330 QTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASY 394
                 :..:..:..:....|:|:...||::..::|||..|||..|...:.:.|..|...:  :.:
plant   486 -----QRNNGYQFSLMGNRDSRMKATNEMLNYMRVIKFQAWENHFNKRILKFRDMEFGWL--SKF 543

  Fly   395 LRGFYLSTMVFTERSTLY--ITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAE 457
            |.....:.:|......|.  :|.|.|..:|..:.|..||:..:.:.|||..... :|.::...::
plant   544 LYSIAGNIIVLWSTPVLISALTFATALALGVKLDAGTVFTTTTIFKILQEPIRT-FPQSMISLSQ 607

  Fly   458 ALVSLRRIQDFLM----LEGREERTQGLTHKRDQEGGDSRAVTIKDINASWDIEKPQKTLQSINL 518
            |::||.|:..::|    .|...||..|.      :|  :.||.::|.:.|||.|..:..|..||.
plant   608 AMISLGRLDSYMMSKELSEDAVERALGC------DG--NTAVEVRDGSFSWDDEDNEPALSDINF 664

  Fly   519 QIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEE 583
            :::||:|.|::|.||:||||:|..:|||:..|.|.|.:.|...|.||..|:..|:|::|||||..
plant   665 KVKKGELTAIVGTVGSGKSSLLASVLGEMHRISGQVRVCGSTGYVAQTSWIENGTVQDNILFGLP 729

  Fly   584 FDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLS 648
            ..|::|.:|...|:|..|.|.:..||||.:||||.:|||||:.||.||||||:...:||:||..|
plant   730 MVREKYNKVLNVCSLEKDLQMMEFGDKTEIGERGINLSGGQKQRIQLARAVYQECDVYLLDDVFS 794

  Fly   649 AVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSD 713
            |||||.|..:|.:.:  ||.|.  ..|.:||||||.||...|.|:::..|:|:..|.|.||::|.
plant   795 AVDAHTGSDIFKKCV--RGALK--GKTVLLVTHQVDFLHNVDCILVMRDGKIVESGKYDELVSSG 855

  Fly   714 LDFARLLERPKEE----EEGENS-------RNQTSPLSVN---SLES------DDEDIPFIDG-- 756
            |||..|:...:..    |.|.:|       |..|||.:.:   |:||      :||.|....|
plant   856 LDFGELVAAHETSMELVEAGADSAAVATSPRTPTSPHASSPRTSMESPHLSDLNDEHIKSFLGSH 920

  Fly   757 -VKDGYQQLRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISPRVWYEYFHAGSTLLSFSF 820
             |:||.:.:::                          |.:.:|.:|..|:.:|............
plant   921 IVEDGSKLIKE--------------------------EERETGQVSLGVYKQYCTEAYGWWGIVL 959

  Fly   821 MVFVMVMSQVVCSSSDFFANIWTQQEHQRSQGEATFSTFECMYIYGALIIAVV--IMTTFRGFLF 883
            ::|..:..|....:||:    |...|   :..:...|....::|.|.:|||:|  ::.:.|.:..
plant   960 VLFFSLTWQGSLMASDY----WLAYE---TSAKNAISFDASVFILGYVIIALVSIVLVSIRSYYV 1017

  Fly   884 FKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALV-- 946
            ..:.:..:::...::...||||.|.|||||||||||:|.|.|...:|.|:|      ..:.||
plant  1018 THLGLKTAQIFFRQILNSILHAPMSFFDTTPSGRILSRASTDQTNVDILIP------FMLGLVVS 1076

  Fly   947 MFGILIVIGILN-----PVLVAAMLVVAV--VDVLILKLYLRPSQDLKRLEGICRSPVFSHLSAS 1004
            |:..|:.|.|:.     |   .|..|:.:  :::.....||..|::|.|::.|.::|:..|.|.|
plant  1077 MYTTLLSIFIVTCQYAWP---TAFFVIPLGWLNIWYRNYYLASSRELTRMDSITKAPIIHHFSES 1138

  Fly  1005 LTGLAIIRSRQLQDVVAKE------FDLLQDVH---SSVW---QLTMAVNTTLGLWLDCVSCIFL 1057
            :.|:..|||.:.|::..:|      .:|..|.|   |:.|   :|.:     :|.|:.|:|.:|:
plant  1139 IAGVMTIRSFRKQELFRQENVKRVNDNLRMDFHNNGSNEWLGFRLEL-----VGSWVLCISALFM 1198

  Fly  1058 TSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTEL--EQEP 1120
            .      ::.|......||||:::..:.|..::.:.:........:|.||||:.|:|::  |.|.
plant  1199 V------LLPSNVIRPENVGLSLSYGLSLNSVLFFAIYMSCFVENKMVSVERIKQFTDIPSESEW 1257

  Fly  1121 ALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALF 1185
            ...|..||..||..|.|...::..||.||...||:.:.|.|:.|.|||:|||||:|||:||..||
plant  1258 ERKETLPPSNWPFHGNVHLEDLKVRYRPNTPLVLKGITLDIKGGEKVGVVGRTGSGKSTLIQVLF 1322

  Fly  1186 RLAHIE-GEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDV 1249
            ||.... |:|.||||:..|:.|..||:|..||||:||||..|:|.|:||.|:|:|.|:|.:||..
plant  1323 RLVEPSGGKIIIDGIDISTLGLHDLRSRFGIIPQEPVLFEGTVRSNIDPTEQYSDEEIWKSLERC 1387

  Fly  1250 ELRKAI----PGLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRT 1310
            :|:..:    ..||.:|.:.|.|:||||||||||.|.:|:.:::|.||||||:||.||||:||:.
plant  1388 QLKDVVATKPEKLDSLVVDNGENWSVGQRQLLCLGRVMLKRSRLLFLDEATASVDSQTDAVIQKI 1452

  Fly  1311 IRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKK 1356
            ||..|..||::::|||:.||||.||::|:|||.|.|||.|..||::
plant  1453 IREDFASCTIISIAHRIPTVMDGDRVLVIDAGKAKEFDSPARLLER 1498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	436/1411 (31%)
		ABC_membrane	214..441	CDD:294371	57/239 (24%)
		ABCC_MRP_domain1	495..699	CDD:213217	93/203 (46%)
		ABC_membrane	863..1088	CDD:294371	71/247 (29%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	114/219 (52%)
ABCC4	NP_182301.1	CFTR_protein	255..1502	CDD:273530	436/1411 (31%)
		ABC_membrane	331..595	CDD:294371	68/359 (19%)
		ABCC_MRP_domain1	641..841	CDD:213217	93/203 (46%)
		ABC_membrane	976..1229	CDD:294371	74/279 (27%)
		ABCC_MRP_domain2	1272..1492	CDD:213211	114/219 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720