DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and ABCC2

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_001189675.1	Gene:	ABCC2 / 818031	AraportID:	AT2G34660	Length:	1623	Species:	Arabidopsis thaliana

Alignment Length:	1436	Identity:	453/1436 - (31%)
Similarity:	711/1436 - (49%)	Gaps:	212/1436 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRKKQ 76
            |.:||||..::.|:|..||:..||:|.|...|:......|::|.|....:..|.|||:     |.
plant   227 PEKHANIFDKIFFSWMNPLMTLGSKRPLTEKDVWYLDTWDQTETLFTSFQHSWDKELQ-----KP 286

  Fly    77 KPHLRNALFR-----------------C--FLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQK 122
            :|.|..||..                 |  |:||.::|                   |||...|:
plant   287 QPWLLRALNNSLGGRFWWGGFWKIGNDCSQFVGPLLLN-------------------QLLKSMQE 332

  Fly   123 TPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPV 187
            ...|.:..|                    |..|..|.
plant   333 DAPAWMGYI--------------------YAFSIFVG---------------------------- 349

  Fly   188 EEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLI 252
                    .|..:|.: .::..|.|.                          :|.|:|.|..:.:
plant   350 --------VVFGVLCE-AQYFQNVMR--------------------------VGYRLRSALIAAV 379

  Fly   253 YRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIV 317
            :||:|||:.:...:...|.:.||::.|...|......:|.:|..|.:.::...|::..:|:.:::
plant   380 FRKSLRLTNEGRRKFQTGKITNLMTTDAESLQQICQSLHTMWSAPFRIIIALILLYQQLGVASLI 444

  Fly   318 GVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEAR 382
            |.: ||:...|:||.:......|.....:|||.|:|:|||::..:..:|.||||..||:.|...|
plant   445 GAL-LLVLMFPLQTVIISKMQKLTKEGLQRTDKRIGLMNEVLAAMDTVKCYAWENSFQSKVQTVR 508

  Fly   383 RSEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIW 447
            ..|:...|.:..|....:..:.........::.....|:|..:|....|::.|.:.:|:. ....
plant   509 DDELSWFRKSQLLGALNMFILNSIPVLVTIVSFGVFTLLGGDLTPARAFTSLSLFAVLRF-PLFM 572

  Fly   448 YPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINASWDIEKPQKT 512
            .|..::....|.|||:|:::.|   ..|||.  |......|.|:. |::|::...|||.:..:.|
plant   573 LPNIITQVVNANVSLKRLEEVL---ATEERI--LLPNPPIEPGEP-AISIRNGYFSWDSKGDRPT 631

  Fly   513 LQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVI-DGGVFIQGDLSYAAQEPWLFTGSVRN 576
            |.:|||.:..|.|.||:|..|.||:|::..:|||||.. |..|.::|.::|..|..|:|..:||:
plant   632 LSNINLDVPLGSLVAVVGSTGEGKTSLISAILGELPATSDAIVTLRGSVAYVPQVSWIFNATVRD 696

  Fly   577 NILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIY 641
            |||||..|||::|:......:|..|.:.||.||.|.:||||.::||||:.|:|:|||||..:.:|
plant   697 NILFGSPFDREKYERAIDVTSLKHDLELLPGGDLTEIGERGVNISGGQKQRVSMARAVYSNSDVY 761

  Fly   642 LMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTY 706
            :.||||||:|||||:.:|::.|  :..|.|  .||:|||:|:||||:.|.||:|.:|.:..:|||
plant   762 IFDDPLSALDAHVGQQVFEKCI--KRELGQ--KTRVLVTNQLHFLSQVDRIVLVHEGTVKEEGTY 822

  Fly   707 QELINSDLDFARLLERPKE-----EEEGENSRNQTSPLSV-----NSLESDDEDIPFIDGVKDGY 761
            :||.::...|.||:|...:     ||.||...:||:...|     |.|:.|..|
plant   823 EELSSNGPLFQRLMENAGKVEEYSEENGEAEADQTAEQPVANGNTNGLQMDGSD----------- 876

  Fly   762 QQLRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISPRVWYEYFHAGSTLLSFSFMVFVMV 826
             ..:.:..:..|.||:...|           |.:.:|.:|.||...|..|.........::...|
plant   877 -DKKSKEGNKKGGKSVLIKQ-----------EERETGVVSWRVLKRYQDALGGAWVVMMLLLCYV 929

  Fly   827 MSQVVCSSSDFFANIWTQQEHQRSQGEATFSTFECMYIYGALIIAVVIMTTFRGFLFFKICMHAS 891
            :::|...:|..:.:.||.....:|.|...::     .||..|....|::|....:......::|:
plant   930 LTEVFRVTSSTWLSEWTDAGTPKSHGPLFYN-----LIYALLSFGQVLVTLTNSYWLIMSSLYAA 989

  Fly   892 KVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGI 956
            |.|||.|...||.|.|.||.|.|.|||:|||:||:|.||..:...:..|:.....:...:::|||
plant   990 KKLHDNMLHSILRAPMSFFHTNPLGRIINRFAKDLGDIDRTVAVFVNMFMGQVSQLLSTVVLIGI 1054

  Fly   957 LNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVA 1021
            ::.:.:.|::.:.|:.......|...::::||::.|.||||::....:|.||:.||:       .
plant  1055 VSTLSLWAIMPLLVLFYGAYLYYQNTAREVKRMDSISRSPVYAQFGEALNGLSTIRA-------Y 1112

  Fly  1022 KEFDLLQDVHSSVWQ-------LTMAVNTTLGLWLDCVSCIFLTSVTFSFII------SSETTYS 1073
            |.:|.:.|::.....       :.|..|..||:.|:.:..:.:. :|.||.:      .::..::
plant  1113 KAYDRMADINGRSMDNNIRFTLVNMGANRWLGIRLETLGGLMIW-LTASFAVMQNGRAENQQAFA 1176

  Fly  1074 GNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTEL--EQEPALGEKTPPQQWPTRGQ 1136
            ..:||.::.|:.:|.::...:|..:.:...:.:||||..|.|:  |..|.:....||..||:.|.
plant  1177 STMGLLLSYALNITSLLTGVLRLASLAENSLNAVERVGNYIEIPPEAPPVIENNRPPPGWPSSGS 1241

  Fly  1137 VEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHIE-GEIFIDGIE 1200
            ::|.::..||.|...|||..::..|....|||||||||||||||:.||||:..:| |.|.||..:
plant  1242 IKFEDVVLRYRPQLPPVLHGVSFFIHPTDKVGIVGRTGAGKSSLLNALFRIVEVEKGRILIDDCD 1306

  Fly  1201 TGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAIP----GLDYM 1261
            .|...|..||..:.||||.|||||.|:|:|||||..:.||:||.:||...|:..|.    |||..
plant  1307 VGKFGLMDLRKVLGIIPQSPVLFSGTVRFNLDPFGEHNDADLWESLERAHLKDTIRRNPLGLDAE 1371

  Fly  1262 VTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHR 1326
            |:|.|.||||||||||.|:||:||.:|:||||||||.||.:||||||:|||.:||.||:|.:|||
plant  1372 VSEAGENFSVGQRQLLSLSRALLRRSKILVLDEATAAVDVRTDALIQKTIREEFKSCTMLIIAHR 1436

  Fly  1327 LHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEATG-GESEALK------KTASDSHK 1384
            |:|::|.|:|:|:|:|...||..|..||........:||::|| ..:|.|:      |.|.|...
plant  1437 LNTIIDCDKILVLDSGRVQEFSSPENLLSNEGSSFSKMVQSTGAANAEYLRSLVLDNKRAKDDSH 1501

  Fly  1385 RMQRER 1390
            .:|.:|
plant  1502 HLQGQR 1507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	444/1404 (32%)
		ABC_membrane	214..441	CDD:294371	51/226 (23%)
		ABCC_MRP_domain1	495..699	CDD:213217	93/204 (46%)
		ABC_membrane	863..1088	CDD:294371	63/237 (27%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	120/219 (55%)
ABCC2	NP_001189675.1	PLN03130	1..1623	CDD:215595	453/1436 (32%)
		ABC_membrane	309..570	CDD:279056	70/364 (19%)
		ABCC_MRP_domain1	614..815	CDD:213217	93/204 (46%)
		ABC_membrane	925..1179	CDD:294371	67/266 (25%)
		ABCC_MRP_domain2	1240..1460	CDD:213211	120/219 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	86	1.000	Domainoid score	I2776
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720