DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and Abcc6

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_112275.1	Gene:	Abcc6 / 81642	RGDID:	620268	Length:	1502	Species:	Rattus norvegicus

Alignment Length:	1441	Identity:	442/1441 - (30%)
Similarity:	689/1441 - (47%)	Gaps:	219/1441 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AKPTRKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQW---FK 66
            :||....|...|:..|:.:|.||..||::|.|:.|...||....:|:.||:|..:||.:|   |.
  Rat   203 SKPLNPCPEAEASFPSKAMFWWASGLLWKGYRKLLGPKDLWSLERENSSEELVSQLEREWRRNFS 267

  Fly    67 EL--ERSH---------------RKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLA 114
            ||  .:.|               |.::.|.|| |::|.|....::..|...|....:..:|.:|:
  Rat   268 ELPGHKGHSGMGTPETEAFLQPERSQRGPLLR-AIWRVFRSTFLLGTLSLVISDAFRFAVPKLLS 331

  Fly   115 QLLIQFQKTPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGP 179
             |.::|.                                            ||
  Rat   332 -LFLEFM--------------------------------------------GD------------ 339

  Fly   180 LEPIQPPVEEVDHNATAVRSILDQTVEHMWNDMNSLGAVLV-----LSTLFCCFLLHHVDLRQRL 239
                                 |:.:....|     |.|||:     |.|||....::.|    ::
  Rat   340 ---------------------LESSAWTGW-----LLAVLMFLSACLQTLFEQQYMYRV----KV 374

  Fly   240 MGARMRIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTC 304
            :..|:|.|...|:|||.|.||..:...:.||.::||:|.||.||....:.::.:|::.|..::..
  Rat   375 LQMRLRTAITGLVYRKVLVLSSGSRKSSAAGDVVNLVSVDVQRLVESILHLNGLWLLFLWIIVCF 439

  Fly   305 YLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYA 369
            ..:|..:| |:.:..|.:.|..:|:...::|..|..:.....:..:|..:.:.:::.::.||.:.
  Rat   440 VYLWQLLG-PSALTAVAVFLSLLPLNFFITKKRSFHQEEQMRQKASRARLTSSMLRTVRTIKSHG 503

  Fly   370 WEKPFQAVVAEARRSEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAAL-----MGQTITADF 429
            ||..|...:...|..|:..::.:::|  |.:|.:.| :.||..:.|...|:     ....:.|:.
  Rat   504 WECAFLERLLHIRGQELGALKTSAFL--FSVSLVSF-QVSTFLVALVVFAVHTLVAEDNAMDAEK 565

  Fly   430 VFSAASYYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRA 494
            .|...:..:||....| :.|.:|....:|.||..|:..||.||  |....|:.....:.....|
  Rat   566 AFVTLTVLSILNKAQA-FLPFSVHCLVQARVSFDRLAAFLCLE--EVDPNGMVLSPSRCSSKDR- 626

  Fly   495 VTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGD 559
            ::|.:...:|..|.| ..|..|||.:.:|.|.||:|||||||||:|..|||||..::|.|.|:|.
  Rat   627 ISIHNGTFAWSQESP-PCLHGINLTVPQGCLLAVVGPVGAGKSSLLSALLGELLKVEGSVSIEGS 690

  Fly   560 LSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQ 624
            ::|..||.|:...||..|:.|.:|.|....|||...|||.:|....|.|..|.|||:|.:|||||
  Rat   691 VAYVPQEAWVQNTSVVENVCFRQELDLPWLQEVLEACALGSDVASFPAGVHTPVGEQGMNLSGGQ 755

  Fly   625 RARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEA 689
            :.|:|||||||:.|.:|||||||:|:||||.:.:|.:||||.|.|.  ..|||||||.:|.|.:|
  Rat   756 KQRLSLARAVYRRAAVYLMDDPLAALDAHVSQEVFKQVIGPSGLLQ--GTTRILVTHTLHVLPQA 818

  Fly   690 DVIVIVDQGRILRQGTYQELINSD------LDFARLLERPKEEEEGENSRNQTSPLSVNSLESDD 748
            |.|:::..|.|...|:||:|::.:      ||.||   :|..|.|||.....|         |||
  Rat   819 DQILVLANGTIAEMGSYQDLLHRNGALVGLLDGAR---QPAGEGEGEAHAAAT---------SDD 871

  Fly   749 EDIPFIDGVKDGYQQLRK-------QSSSVHGSKSLDSTQLDDNVDEDDLAEAQAS------GGI 800
                 :.|...|....|:       .::.|.||.|  ..|::.::|:.::....|.      |.:
  Rat   872 -----LGGFSGGGTPTRRPERPRPSDAAPVKGSTS--EAQMEPSLDDVEVTGLTAGEDSVQYGRV 929

  Fly   801 SPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWT-------QQEHQRSQGEATFST 858
            ....:..|..|..|.|. ::.:|:.:..||......::.::|.       :|.|...:| :.|..
  Rat   930 KSATYLSYLRAVGTPLC-TYTLFLFLCQQVASFCQGYWLSLWADDPVVDGKQMHSALRG-SIFGL 992

  Fly   859 FECMYIYGALI-IAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRF 922
            ..|:...|... :|.|.:...|.     .|:....:|.|     :..:.:.||:.||.|.:||||
  Rat   993 LGCLQAIGLFASMAAVFLGGARA-----SCLLFRSLLWD-----VARSPIGFFERTPVGNLLNRF 1047

  Fly   923 SKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLK 987
            ||:...:|..:|..|...:..|..:..:.:.:.:..|:.:.|:|.:.::......||:.....|:
  Rat  1048 SKETDIVDVDIPDKMRTLLTYAFGLLEVGLAVSMATPLAIVAILPLMLLYAGFQSLYVATCCQLR 1112

  Fly   988 RLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSV---------WQLTMAVNT 1043
            |||....|.|.|||:.:..|..::|:.|.|.....:.|.|.|.:..:         |   :|.|.
  Rat  1113 RLESASYSSVCSHLAETFQGSQVVRAFQAQGPFTAQHDALMDENQRISFPRLVADRW---LAANL 1174

  Fly  1044 TL---GLWLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMT 1105
            .|   ||.....:|..|:....|         :|..|.:::.|:.:|..:|:.||...:....|.
  Rat  1175 ELLGNGLVFVAATCAVLSKAHLS---------AGLAGFSVSAALQVTQTLQWVVRSWTDLENSMV 1230

  Fly  1106 SVERVLQYTELEQEP--ALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVG 1168
            :||||..|....:|.  .|........||..||:|||:...|:.|.....::.::|.|.||.|||
  Rat  1231 AVERVQDYVHTPKEAPWRLPSSAAQPLWPCGGQIEFRDFGLRHRPELPMAVQGVSLKIHAGEKVG 1295

  Fly  1169 IVGRTGAGKSSLIGALFRLAH-IEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLD 1232
            ||||||||||||...|.||.. .||.|:|||:....:.|..||:||:|||||||||..::|.|||
  Rat  1296 IVGRTGAGKSSLTWGLLRLQEATEGGIWIDGVPITDMGLHTLRSRITIIPQDPVLFPGSLRMNLD 1360

  Fly  1233 PFERYTDAELWSALEDVELR---KAIPG-LDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLD 1293
            ..:..||..:|:|||.|:|:   .::|| |.|..:.:|.:.||||:||||||||:||..::|:||
  Rat  1361 LLQENTDEGIWAALETVQLKAFVTSLPGQLQYECSGQGDDLSVGQKQLLCLARALLRKTQILILD 1425

  Fly  1294 EATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQ 1358
            ||||:|||.|:..:|..:...|.|||||.:||||.:||:..|::|||.|...|...|..||.: :
  Rat  1426 EATASVDPGTEIQMQAALERWFAQCTVLLIAHRLRSVMNCARVLVMDEGQVAESGSPAQLLAQ-K 1489

  Fly  1359 GHLRQMVEATG 1369
            |...::.:.:|
  Rat  1490 GLFYRLAQESG 1500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	439/1433 (31%)
		ABC_membrane	214..441	CDD:294371	57/236 (24%)
		ABCC_MRP_domain1	495..699	CDD:213217	100/203 (49%)
		ABC_membrane	863..1088	CDD:294371	55/237 (23%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	110/219 (50%)
Abcc6	NP_112275.1	MRP_assoc_pro	36..1501	CDD:188098	442/1441 (31%)
		ABC_membrane	313..577	CDD:294371	67/354 (19%)
		ABCC_MRP_domain1	627..828	CDD:213217	100/203 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	854..909		17/70 (24%)
		ABC_membrane	950..1215	CDD:294371	65/287 (23%)
		ABCC_MRP_domain2	1262..1482	CDD:213211	110/219 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720