Protein Alignment Cftr and Abcc6

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_112275.1
• Gene: Abcc6 / 81642
• RGDID: 620268
• Length: 1502
• Species: Rattus norvegicus
• Alignment Length: 1441
• Identity: 442/1441 - (30%)
• Similarity: 689/1441 - (47%)
• Gaps: 219/1441 - (15%)

  Fly     5 AKPTRKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQW---FK 66
            :||....|...|:..|:.:|.||..||::|.|:.|...||....:|:.||:|..:||.:|   |.
  Rat   203 SKPLNPCPEAEASFPSKAMFWWASGLLWKGYRKLLGPKDLWSLERENSSEELVSQLEREWRRNFS 267

  Fly    67 EL--ERSH---------------RKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLA 114
            ||  .:.|               |.::.|.|| |::|.|....::..|...|....:..:|.:|:
  Rat   268 ELPGHKGHSGMGTPETEAFLQPERSQRGPLLR-AIWRVFRSTFLLGTLSLVISDAFRFAVPKLLS 331

  Fly   115 QLLIQFQKTPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGP 179
             |.::|.                                            ||
  Rat   332 -LFLEFM--------------------------------------------GD------------ 339

  Fly   180 LEPIQPPVEEVDHNATAVRSILDQTVEHMWNDMNSLGAVLV-----LSTLFCCFLLHHVDLRQRL 239
                                 |:.:....|     |.|||:     |.|||....::.|    ::
  Rat   340 ---------------------LESSAWTGW-----LLAVLMFLSACLQTLFEQQYMYRV----KV 374

  Fly   240 MGARMRIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTC 304
            :..|:|.|...|:|||.|.||..:...:.||.::||:|.||.||....:.::.:|::.|..::..
  Rat   375 LQMRLRTAITGLVYRKVLVLSSGSRKSSAAGDVVNLVSVDVQRLVESILHLNGLWLLFLWIIVCF 439

  Fly   305 YLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYA 369
            ..:|..:| |:.:..|.:.|..:|:...::|..|..:.....:..:|..:.:.:::.::.||.:.
  Rat   440 VYLWQLLG-PSALTAVAVFLSLLPLNFFITKKRSFHQEEQMRQKASRARLTSSMLRTVRTIKSHG 503

  Fly   370 WEKPFQAVVAEARRSEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAAL-----MGQTITADF 429
            ||..|...:...|..|:..::.:::|  |.:|.:.| :.||..:.|...|:     ....:.|:.
  Rat   504 WECAFLERLLHIRGQELGALKTSAFL--FSVSLVSF-QVSTFLVALVVFAVHTLVAEDNAMDAEK 565

  Fly   430 VFSAASYYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRA 494
            .|...:..:||....| :.|.:|....:|.||..|:..||.||  |....|:.....:.....|
  Rat   566 AFVTLTVLSILNKAQA-FLPFSVHCLVQARVSFDRLAAFLCLE--EVDPNGMVLSPSRCSSKDR- 626

  Fly   495 VTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGD 559
            ::|.:...:|..|.| ..|..|||.:.:|.|.||:|||||||||:|..|||||..::|.|.|:|.
  Rat   627 ISIHNGTFAWSQESP-PCLHGINLTVPQGCLLAVVGPVGAGKSSLLSALLGELLKVEGSVSIEGS 690

  Fly   560 LSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQ 624
            ::|..||.|:...||..|:.|.:|.|....|||...|||.:|....|.|..|.|||:|.:|||||
  Rat   691 VAYVPQEAWVQNTSVVENVCFRQELDLPWLQEVLEACALGSDVASFPAGVHTPVGEQGMNLSGGQ 755

  Fly   625 RARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEA 689
            :.|:|||||||:.|.:|||||||:|:||||.:.:|.:||||.|.|.  ..|||||||.:|.|.:|
  Rat   756 KQRLSLARAVYRRAAVYLMDDPLAALDAHVSQEVFKQVIGPSGLLQ--GTTRILVTHTLHVLPQA 818

  Fly   690 DVIVIVDQGRILRQGTYQELINSD------LDFARLLERPKEEEEGENSRNQTSPLSVNSLESDD 748
            |.|:::..|.|...|:||:|::.:      ||.||   :|..|.|||.....|         |||
  Rat   819 DQILVLANGTIAEMGSYQDLLHRNGALVGLLDGAR---QPAGEGEGEAHAAAT---------SDD 871

  Fly   749 EDIPFIDGVKDGYQQLRK-------QSSSVHGSKSLDSTQLDDNVDEDDLAEAQAS------GGI 800
                 :.|...|....|:       .::.|.||.|  ..|::.::|:.::....|.      |.:
  Rat   872 -----LGGFSGGGTPTRRPERPRPSDAAPVKGSTS--EAQMEPSLDDVEVTGLTAGEDSVQYGRV 929

  Fly   801 SPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWT-------QQEHQRSQGEATFST 858
            ....:..|..|..|.|. ::.:|:.:..||......::.::|.       :|.|...:| :.|..
  Rat   930 KSATYLSYLRAVGTPLC-TYTLFLFLCQQVASFCQGYWLSLWADDPVVDGKQMHSALRG-SIFGL 992

  Fly   859 FECMYIYGALI-IAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRF 922
            ..|:...|... :|.|.:...|.     .|:....:|.|     :..:.:.||:.||.|.:||||
  Rat   993 LGCLQAIGLFASMAAVFLGGARA-----SCLLFRSLLWD-----VARSPIGFFERTPVGNLLNRF 1047

  Fly   923 SKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLK 987
            ||:...:|..:|..|...:..|..:..:.:.:.:..|:.:.|:|.:.::......||:.....|:
  Rat  1048 SKETDIVDVDIPDKMRTLLTYAFGLLEVGLAVSMATPLAIVAILPLMLLYAGFQSLYVATCCQLR 1112

  Fly   988 RLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSV---------WQLTMAVNT 1043
            |||....|.|.|||:.:..|..::|:.|.|.....:.|.|.|.:..:         |   :|.|.
  Rat  1113 RLESASYSSVCSHLAETFQGSQVVRAFQAQGPFTAQHDALMDENQRISFPRLVADRW---LAANL 1174

  Fly  1044 TL---GLWLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMT 1105
            .|   ||.....:|..|:....|         :|..|.:::.|:.:|..:|:.||...:....|.
  Rat  1175 ELLGNGLVFVAATCAVLSKAHLS---------AGLAGFSVSAALQVTQTLQWVVRSWTDLENSMV 1230

  Fly  1106 SVERVLQYTELEQEP--ALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVG 1168
            :||||..|....:|.  .|........||..||:|||:...|:.|.....::.::|.|.||.|||
  Rat  1231 AVERVQDYVHTPKEAPWRLPSSAAQPLWPCGGQIEFRDFGLRHRPELPMAVQGVSLKIHAGEKVG 1295

  Fly  1169 IVGRTGAGKSSLIGALFRLAH-IEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLD 1232
            ||||||||||||...|.||.. .||.|:|||:....:.|..||:||:|||||||||..::|.|||
  Rat  1296 IVGRTGAGKSSLTWGLLRLQEATEGGIWIDGVPITDMGLHTLRSRITIIPQDPVLFPGSLRMNLD 1360

  Fly  1233 PFERYTDAELWSALEDVELR---KAIPG-LDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLD 1293
            ..:..||..:|:|||.|:|:   .::|| |.|..:.:|.:.||||:||||||||:||..::|:||
  Rat  1361 LLQENTDEGIWAALETVQLKAFVTSLPGQLQYECSGQGDDLSVGQKQLLCLARALLRKTQILILD 1425

  Fly  1294 EATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQ 1358
            ||||:|||.|:..:|..:...|.|||||.:||||.:||:..|::|||.|...|...|..||.: :
  Rat  1426 EATASVDPGTEIQMQAALERWFAQCTVLLIAHRLRSVMNCARVLVMDEGQVAESGSPAQLLAQ-K 1489

  Fly  1359 GHLRQMVEATG 1369
            |...::.:.:|
  Rat  1490 GLFYRLAQESG 1500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	438/1419 (31%)
Abcc6	NP_112275.1	MRP_assoc_pro	36..1501	CDD:188098	442/1441 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	854..909		17/70 (24%)