DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and ABCC13

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_001323940.1	Gene:	ABCC13 / 815414	AraportID:	AT2G07680	Length:	1426	Species:	Arabidopsis thaliana

Alignment Length:	1413	Identity:	418/1413 - (29%)
Similarity:	688/1413 - (48%)	Gaps:	226/1413 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 FRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISISDSLN--RTAR 147
            |.|.......:.::||.:| .:.|..|:...::...|:..:..|      ||:...|:|  |..:
plant   110 FACCACHVFTSQILCFWWI-FRFLTDALHLNMIFTLQEICLIML------DIAFGISINVLRIKQ 167

  Fly   148 AIPNYVL----------SQAVANSSGSPGDAL---FPKSLDKAGPLEPIQ-------PP------ 186
            |.|..:.          .|.....:||..|..   :..|:.|.|.::.::       ||
plant   168 AHPKIIPLEDPLIEDDDDQKRIEKNGSWWDLFTFGYIGSIMKHGSVKQLELENLLTLPPEMDPFT 232

  Fly   187 ----------VEEVDHNAT------------------------------AVRSILDQTVEHMWND 211
                      ::|.::.:|                              |...:|::.::::...
plant   233 CCENLLRCWQLQECNNYSTPSLIWSIYGVYGWPYFRLGLLKVFNDCIGFAGPLLLNRLIKYLEKG 297

  Fly   212 M-NSLGAVLVLS----TLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKTAGQTPAGY 271
            . :|:|..|.:|    ::|..||......|...:..::|.:..|:||||.|.::.........|.
plant   298 SGSSVGYTLAISLGFISIFKSFLDTQYTFRLSKLKLKLRSSIMSVIYRKCLWVNTANRSGFSEGE 362

  Fly   272 LINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGV-VGLLLKTVPVQTALSK 335
            :...:|.|.:|:......:|.:|.:|||..:..||::..:....:.|: :.:||  :||...:|.
plant   363 IQTFMSVDADRIVNLCNSLHDLWSLPLQIGIALYLLYTQVKFAFLSGLAITILL--IPVNKWISV 425

  Fly   336 VTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRG--- 397
            :.:....::.:..|.|:....||:..|:.:|||.|:..|...:.|.|.:|:..:....||..
plant   426 LIASATEKMMKLKDERIRKTGELLTNIRTLKMYGWDNWFADWLKETRATEVTHLATRKYLDAWCV 490

  Fly   398 FYLSTMVFTERSTLY--ITLAAAALMGQTITADFVFSAASYYNILQLVAAI-WYPLAVSFGAEAL 459
            |:.:|     ..||:  .|....||||..:.|..||:..:.:|  .|::.: .:|..::...:|.
plant   491 FFWAT-----TPTLFSLCTFGLFALMGHQLDAATVFTCLALFN--SLISPLNSFPWVINGLIDAF 548

  Fly   460 VSLRRIQDFLMLEGREERTQGLTHKRD---QEG--GDSRAVTIKDINASW--DIEKPQK-TLQSI 516
            :|.||:..||..         |.|.||   ..|  .:..||.::|.:.:|  ::|:... |::.:
plant   549 ISTRRVSKFLCC---------LEHSRDFSIDSGFTSEDLAVCVEDASCTWSSNVEEDYNLTIKQV 604

  Fly   517 NLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFG 581
            :|::.||...||||.||:||:|:|..||||:..:.|.:.:.|.::|..|.|||.:|:||.|||||
plant   605 SLRVPKGSFVAVIGEVGSGKTSLLNSLLGEMRCVHGSILLNGSVAYVPQVPWLLSGTVRENILFG 669

  Fly   582 EEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDP 646
            :.||.|||.|....|||..|...:..||...:|::|.:||||||||.:||||||..:.:||:||.
plant   670 KPFDSKRYFETLSACALDVDISLMVGGDMACIGDKGLNLSGGQRARFALARAVYHGSDMYLLDDV 734

  Fly   647 LSAVDAHVGRHLFDE-VIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELI 710
            |||||:.||..:... ::||    ...|.||::.||.:..:|.||:||::|:|::...|:..::
plant   735 LSAVDSQVGCWILQRALLGP----LLNKKTRVMCTHNIQAISCADMIVVMDKGKVNWSGSVTDM- 794

  Fly   711 NSDLDFARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVHGSK 775
                        ||......:..|:....|.|.|..                  ||::.|:.
plant   795 ------------PKSISPTFSLTNEFDMSSPNHLTK------------------RKETLSIK--- 826

  Fly   776 SLDSTQLDDNVDEDDLAEAQA---------SGGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVV 831
                   :|.|||  ::||.|         .|.:...|:..|     .:.|..|:..|:::|.|:
plant   827 -------EDGVDE--ISEAAADIVKLEERKEGRVEMMVYRNY-----AVFSGWFITIVILVSAVL 877

  Fly   832 CSSS----DFFANIWTQQEHQRSQGEATFSTFECMYIYGALIIAVV--IMTTFRGFLF----FKI 886
            ...|    |.:.:.|..   :..:|.:.:||  ..|:....|..::  |:|..|.|.|    .|.
plant   878 MQGSRNGNDLWLSYWVD---KTGKGVSHYST--SFYLMVLCIFCIINSILTLVRAFSFAFGGLKA 937

  Fly   887 CMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFI-QIALVMF-G 949
            .:|    :|:.:.:.:::|..:|||.|||||||||||.|:..||:.||     || .|.|..| |
plant   938 AVH----VHNALISKLINAPTQFFDQTPSGRILNRFSSDLYTIDDSLP-----FILNILLANFVG 993

  Fly   950 ILIVIGILNPVLVAAMLVVAVVDVLILKL---YLRPSQDLKRLEGICRSPVFSHLSASLTGLAII 1011
            :|.:|.:|:.|.|..:|::.....:..||   |...|::|:||:.:.|||:::..:.:|.|.:.|
plant   994 LLGIIVVLSYVQVLFLLLLLPFWYIYSKLQVFYRSTSRELRRLDSVSRSPIYASFTETLDGSSTI 1058

  Fly  1012 RSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDC------------VSCIFLTSVTFSF 1064
            |:.:.::.....|    ..|.:::|.|........|||..            |:.:.:.....:|
plant  1059 RAFKSEEHFVGRF----IEHLTLYQRTSYSEIIASLWLSLRLQLLGSMIVLFVAVMAVLGSGGNF 1119

  Fly  1065 IISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQEPALGEKTPPQ 1129
            .||..|  .|.||||::.|..|..::...:....|:.::|.||||||||.::.||...|.::...
plant  1120 PISFGT--PGLVGLALSYAAPLVSLLGSLLTSFTETEKEMVSVERVLQYMDVPQEEVSGPQSLSD 1182

  Fly  1130 QWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHI-EGE 1193
            :||..|.|||.|::.||.....|.|..::.||:.|..||::|||||||||::.|||||..: .||
plant  1183 KWPVHGLVEFHNVTMRYISTLPPALTQISFTIQGGMHVGVIGRTGAGKSSILNALFRLTPVCSGE 1247

  Fly  1194 IFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAIP-- 1256
            |.:||.....:.:..||:.::::||.|.||..::|.||||.....|..:|..|:..:::.|:.
plant  1248 ILVDGKNISHLPIRELRSCLAVVPQSPFLFQGSLRDNLDPLGLSEDWRIWEILDKCKVKAAVESV 1312

  Fly  1257 -GLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTV 1320
             |||..|.|.|.:||||||||||||||:|:::|:|.|||.|||:|..|.:|:..||..:.|..||
plant  1313 GGLDSYVKESGCSFSVGQRQLLCLARALLKSSKILCLDECTANIDVHTASLLHNTISSECKGVTV 1377

  Fly  1321 LTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEAT 1368
            :|:|||:.||:|.|.|:::|.|:.||...|..||:.........|.|:
plant  1378 ITIAHRISTVVDLDSILILDRGILVEQGKPQHLLQDDSSTFSSFVRAS 1425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	417/1410 (30%)
		ABC_membrane	214..441	CDD:294371	60/236 (25%)
		ABCC_MRP_domain1	495..699	CDD:213217	89/207 (43%)
		ABC_membrane	863..1088	CDD:294371	75/247 (30%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	99/218 (45%)
ABCC13	NP_001323940.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	50	1.000	Domainoid score	I4365
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720