DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and Abcc3

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_001350116.1	Gene:	Abcc3 / 76408	MGIID:	1923658	Length:	1523	Species:	Mus musculus

Alignment Length:	1445	Identity:	490/1445 - (33%)
Similarity:	748/1445 - (51%)	Gaps:	201/1445 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TRKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSH 72
            |...|...|...|:|.|.|...|...|.||.|...||....:||.|.::..||.:.|.|:..::.
Mouse   204 TNPCPEASAGFFSRLSFWWFTRLAILGYRRPLEDRDLWSLSEEDCSHKVVQRLLEAWQKQQNQAS 268

  Fly    73 R----------------------KKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQ 115
            |                      |.::|....||.|.|....:::.  ||  .:|:.|:..|..|
Mouse   269 RSQTATAEPKIPGEDAVLLKPRPKSKQPSFLRALVRTFTSSLLMSA--CF--NLIQNLLGFVNPQ 329

  Fly   116 LLIQFQKTPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPL 180
            ||
Mouse   330 LL--------------------------------------------------------------- 331

  Fly   181 EPIQPPVEEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMR 245
                         :..:|.|.|.|....|..:  |..::.||:.....:||.......:|..|:|
Mouse   332 -------------SILIRFISDPTAPTWWGFL--LAGLMFLSSTMQTLILHQYYHCIFVMALRLR 381

  Fly   246 IACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLN 310
            .|...:||||.|.::.....::..|.::||:|.|..|......|::.:|..|||.:|..|.:|..
Mouse   382 TAIIGVIYRKALVITNSVKRESTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQI 446

  Fly   311 IGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQ 375
            :|..|:.||..::| .:|:..|:|......:::..:..|:|:.:|:|::.||:|:|:||||..|.
Mouse   447 LGPSALAGVAVIVL-LIPLNGAVSMKMKTYQVKQMKFKDSRIKLMSEILNGIKVLKLYAWEPSFL 510

  Fly   376 AVVAEARRSEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALMGQT--ITADFVFSAASYYN 438
            ..|...|:||::.:|..:||:.......:.|......|||.....:.::  :.|:..|.:.|.:|
Mouse   511 EQVKGIRQSELQLLRKGAYLQAISTFIWICTPFLVTLITLGVYVYVDESNVLDAEKAFVSLSLFN 575

  Fly   439 ILQLVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINAS 503
            ||::...: .|..:|...:|.|||:|||||  |...|...|.:..|....|   .|:||.:...:
Mouse   576 ILKIPLNM-LPQLISGLTQASVSLKRIQDF--LNQNELDPQCVERKTISPG---YAITIHNGTFT 634

  Fly   504 WDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPW 568
            |..:.| .||.|:|:||.||.|.||:||||.||||::..||||:..::|.|.::|.::|..|:.|
Mouse   635 WAQDLP-PTLHSLNIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGVVSVKGSVAYVPQQAW 698

  Fly   569 LFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARA 633
            :...:::.|:|||:..:.||||:....|||..|...||.||:|.:||:|.:||||||.|:|||||
Mouse   699 IQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLARA 763

  Fly   634 VYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQG 698
            ||..|.|:|:||||||||:||.:|:||:||||.|.||  ..||:||||.:.||.:.|.|:::..|
Mouse   764 VYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLA--GKTRVLVTHGISFLPQTDFIIVLAGG 826

  Fly   699 RILRQGTYQELINSDLDFARLLER--PKEEEEGENSRNQTSPLSVNSLE---------SDDEDIP 752
            ::...|.|..|:..|..||..|..  |.|::|...:..|.:...|..||         :|:|  |
Mouse   827 QVSEMGHYSALLQHDGSFANFLRNYAPDEDQEDHEAALQNANEEVLLLEDTLSTHTDLTDNE--P 889

  Fly   753 FIDGVKDGYQQLRKQSS-SVHG-----------SKSLDSTQLDDNVDE------DDLAEAQASGG 799
            .|..|:.  |.:|:.|| |..|           :.||:...|.....|      :::||   :|.
Mouse   890 AIYEVRK--QFMREMSSLSSEGEVQNRTMPKKHTNSLEKEALVTKTKETGALIKEEIAE---TGN 949

  Fly   800 ISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQ------QEH-QRSQGEATFS 857
            :...|:::|  |.|..|..:..:.::...|   |::...||:|..      :|| |:::......
Mouse   950 VKLSVYWDY--AKSMGLCTTLSICLLYGGQ---SAAAIGANVWLSAWSNDAEEHGQQNKTSVRLG 1009

  Fly   858 TFECMYIYGALIIAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRF 922
            .:..:.|...|::.:...|...|      .:.|:::||:.:....:.:...||||||||||||||
Mouse  1010 VYAALGILQGLLVMLSAFTMVVG------AIQAARLLHEALLHNKIRSPQSFFDTTPSGRILNRF 1068

  Fly   923 SKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLK 987
            |||:..|||:|...::..:.........::||....|:.:..:|.:||:...:.:.|:..|:.||
Mouse  1069 SKDIYVIDEVLAPTILMLLNSFFTSISTIMVIVASTPLFMVVVLPLAVLYGFVQRFYVATSRQLK 1133

  Fly   988 RLEGICRSPVFSHLSASLTGLAIIRS-RQLQDVVAKEFDLLQDVHSSVWQLT----MAVNTTLGL 1047
            |||.|.|||:|||.|.::||.::||: .::||     |.:|.|......|.:    :|.|..||:
Mouse  1134 RLESISRSPIFSHFSETVTGTSVIRAYGRIQD-----FKVLSDTKVDNNQKSSYPYIASNRWLGV 1193

  Fly  1048 WLDCV-SCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVL 1111
            .::.| :|:.|.:..|: :|...:...|.|||:::.|:.:|..:.:.:|.:::....:.:||||.
Mouse  1194 HVEFVGNCVVLFAALFA-VIGRNSLNPGLVGLSVSYALQVTMALNWMIRMISDLESNIIAVERVK 1257

  Fly  1112 QYTELEQE-PALGEKT-PPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTG 1174
            :|::.:.| |.:.|.. .|:.|||||.|||||.|.||.|....||:|:.:.::.|.|||||||||
Mouse  1258 EYSKTKTEAPWVVESNRAPEGWPTRGMVEFRNYSVRYRPGLELVLKNVTVHVQGGEKVGIVGRTG 1322

  Fly  1175 AGKSSLIGALFR-LAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYT 1238
            |||||:...||| |...||||.|||:....|.|..||::::||||||:|||.|:|.|||||.||:
Mouse  1323 AGKSSMTLCLFRILEAAEGEIVIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYS 1387

  Fly  1239 DAELWSALEDVELRKAI----PGLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANV 1299
            :.::|.|||...|...:    .|||:...|.|.|.|||||||:|||||:||.::|||||||||.:
Mouse  1388 EEDIWRALELSHLNTFVSSQPAGLDFQCAEGGDNLSVGQRQLVCLARALLRKSRVLVLDEATAAI 1452

  Fly  1300 DPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQM 1364
            |.:||.|||.|||.:|:.|||||:||||:|:||.:|::|:|.||..|||.|..|:
Mouse  1453 DLETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNLI---------- 1507

  Fly  1365 VEATGGESEALKKTA 1379
              |.||....:.|.|
Mouse  1508 --AAGGIFYGMAKDA 1520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	484/1430 (34%)
		ABC_membrane	214..441	CDD:294371	65/228 (29%)
		ABCC_MRP_domain1	495..699	CDD:213217	100/203 (49%)
		ABC_membrane	863..1088	CDD:294371	73/230 (32%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	125/219 (57%)
Abcc3	NP_001350116.1	MRP_assoc_pro	7..1522	CDD:188098	490/1445 (34%)
Abcc3	NP_001350116.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	903..923		4/19 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1171
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.680