DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and Abcb8

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_083296.2	Gene:	Abcb8 / 74610	MGIID:	1351667	Length:	717	Species:	Mus musculus

Alignment Length:	660	Identity:	155/660 - (23%)
Similarity:	285/660 - (43%)	Gaps:	126/660 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   791 LAEAQASGGISP----------RVWYEYFH-------------AGSTLLSFSFMVFVMVMSQVVC 832
            |.||:.|....|          ::::.:.|             .|:.|::....:.:..:.::|.
Mouse    95 LCEAKESPPAQPTRAPELRFNWKLFWHFLHPHLLALGAAIVLALGAALVNVQIPLLLGQLVEIVA 159

  Fly   833 SSSDFFANIWTQQEHQRS-QGEATFSTFECMYIYGALIIAVVIMTTFRGFLFF------KICMHA 890
            ..:         ::|..| ..|:...:.:.:.:||     |..:.|| |:|..      ::.|..
Mouse   160 KYT---------RDHMGSFVSESRKLSVQLLLLYG-----VQGLLTF-GYLVLLSHIGERMAMDM 209

  Fly   891 SKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIG 955
            .|.|    |:.:|...:.|||...:|::::|.:.|:..........:...::....:.|.|:.:.
Mouse   210 RKAL----FSSLLRQDIAFFDAKKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVIGSLVSLS 270

  Fly   956 ILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLA--------IIR 1012
            :|:|.|.   |::|||...::.:.......|::|...|:..:     |..||:|        .:|
Mouse   271 MLSPRLT---LMLAVVTPALMGVGTLMGSGLRKLSRQCQEQI-----ARATGVADEALGNVRTVR 327

  Fly  1013 SRQLQDVVAKEFDL-LQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSV---------------- 1060
            :..::....:.:.. |:.......:|...:....||.....:|:.|.::
Mouse   328 AFAMEKREEERYQAELESCCCKAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLKGGD 392

  Fly  1061 TFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQE-PALGE 1124
            ..||:::|:|     |..::|...:|.|.|..|          :::..||.:|..|... |..|.
Mouse   393 LMSFLVASQT-----VQRSMASLSVLFGQVVRG----------LSAGARVFEYMALSPVIPLTGG 442

  Fly  1125 KTPPQQWPTRGQVEFRNMSCRYDPN-GSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLA 1188
            ...|.: ..||.:.|:|::..|... |..||::..|.:.:|..|.:||::|.||:::...|.|..
Mouse   443 YCIPNK-DIRGSITFQNVTFSYPCRPGFNVLKDFTLKLPSGKIVALVGQSGGGKTTVASLLERFY 506

  Fly  1189 HIE-GEIFIDGIETGTISLEILRTR-ISIIPQDPVLFSATIRYNLDPFERY-----TDAELWSAL 1246
            ..| |.:.:||.:..|::...||.: |..|.|:||||:.||..|:    |:     :|.|:::|.
Mouse   507 DPEAGSVTLDGHDLRTLNPSWLRGQVIGFISQEPVLFATTIMENI----RFGKLDASDEEVYTAA 567

  Fly  1247 EDVELRKAI----PGLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALI 1307
            .:....:.|    .|...:|.|||...|.||:|.|.:|||:::...||:|||||:.:|.:::.::
Mouse   568 REANAHEFISSFPDGYSTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVV 632

  Fly  1308 QRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEATGGES 1372
            |..:.......|||.:||||.||..:..||||..|...|......||||.           |..|
Mouse   633 QEALDRASAGRTVLVIAHRLSTVRAAHSIIVMANGQVCEAGTHEELLKKG-----------GLYS 686

  Fly  1373 EALKKTASDS 1382
            |.:::...|:
Mouse   687 ELIRRQTLDA 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	151/643 (23%)
		ABC_membrane	214..441	CDD:294371
		ABCC_MRP_domain1	495..699	CDD:213217
		ABC_membrane	863..1088	CDD:294371	48/255 (19%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	76/226 (34%)
Abcb8	NP_083296.2	MdlB	116..695	CDD:224055	149/636 (23%)
Abcb8	NP_083296.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	695..717		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000