DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5789 and ABCC8

DIOPT Version :9

Sequence 1:NP_001247286.1 Gene:CG5789 / 42928 FlyBaseID:FBgn0039207 Length:1402 Species:Drosophila melanogaster
Sequence 2:XP_016873686.1 Gene:ABCC8 / 6833 HGNCID:59 Length:1604 Species:Homo sapiens


Alignment Length:1440 Identity:432/1440 - (30%)
Similarity:679/1440 - (47%) Gaps:265/1440 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   120 FQKTPVAQLRNIDVNDISISDSLNRTARAIPNY----------------------VLSQAVANSS 162
            |.||  |..:.||:..|.   .|....||:.||                      .:.||::::.
Human   236 FIKT--AHKKPIDLRAIG---KLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAF 295

  Fly   163 G-----SPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQTVEHMWNDM-----NSLGA 217
            |     |....:....|..||||               .:..|:|...:.  ||:     ..||.
Human   296 GRRLVLSSTFRILADLLGFAGPL---------------CIFGIVDHLGKE--NDVFQPKTQFLGV 343

  Fly   218 VLVLS------------TLFCCFLLHHVDLRQRL-----MGARMRIACCSLIYRKTLRLSMK--T 263
            ..|.|            .||...||....|:...     .|..:|.|..:.||.|.:.||..  :
Human   344 YFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLS 408

  Fly   264 AGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVP 328
            .|:..||.:.||::.|.|:|.:.|.....:|.||:|.::...|::..:|:.|::|...::| ..|
Human   409 MGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIIL-LAP 472

  Fly   329 VQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYAS 393
            ||..::...|..:....|.::.|:...||:::||:::|:||||..|:..|...||.|:..:|..:
Human   473 VQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFA 537

  Fly   394 YLRGFYLSTMVFTERSTLYITLAAAAL--MGQTI---TADF----VFSAASYYNILQ----LVAA 445
                .|.|..:|...:   |.:||..:  :|...   .|||    .|::.|.::||.    |:::
Human   538 ----IYTSISIFMNTA---IPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSS 595

  Fly   446 IWYPLAVSFGAEALVSLRRIQDFL-MLEGREER------------------TQGL--THKRDQEG 489
            :     |....:||||::::.:|| ..|.|||:                  .:||  .|.....|
Human   596 V-----VRSTVKALVSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVEEGLPSLHSSQPSG 655

  Fly   490 G--------------------DSRAVT--IKDINASWDIEKPQ-----------------KTLQS 515
            .                    |.|.:|  ::.:..|.|.:...                 .||.:
Human   656 SSPPNHPQPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSN 720

  Fly   516 INLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVF------------------------- 555
            |.::|.:|||..::|.||.||||:|...|||:..:.|.||                         
Human   721 ITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSSLPDSEIGEDPSPERETATDLD 785

  Fly   556 --IQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGA 618
              .:|.::||:|:|||...:|..||:|...|:::||:.|...|:|..|...||:||:|.:||||.
Human   786 IRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGI 850

  Fly   619 SLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQV 683
            :||||||.|||:|||:|:.|.:..:|||.||:|.|:..||..  .|....|...|.|.:||||::
Human   851 NLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQ--AGILELLRDDKRTVVLVTHKL 913

  Fly   684 HFLSEADVIVIVDQGRILRQGTYQELINSDLD----FARLLERPKEEEEGE--NSRNQTSPLSVN 742
            .:|..||.|:.:..|.|.|:||.::...|:..    :..|:.|..:|.|.|  ..|..|.|    
Human   914 QYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEP---- 974

  Fly   743 SLESDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISP----- 802
                     |         |.|.:..|      |.|....|:..:|::.||::....:|.     
Human   975 ---------P---------QGLSRAMS------SRDGLLQDEEEEEEEAAESEEDDNLSSMLHQR 1015

  Fly   803 -----RVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQQEHQRSQGEATFS-TFEC 861
                 |...:|..:...|| .|.:||..::..:|..:.|::...||......:......| :.||
Human  1016 AEIPWRACAKYLSSAGILL-LSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQEC 1079

  Fly   862 ---MYIYGALIIAVVIMTTFRGFLFFKICMHAS-----------KVLHDRMFACILHATMRFFDT 912
               ..:| |::..|:..      |...:|:..|           |.||..:...|:.|.||||:|
Human  1080 TLDQTVY-AMVFTVLCS------LGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFET 1137

  Fly   913 TPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILK 977
            ||.|.||||||.|...||:.:|..:....:..|:....|.||..:.||.:.|:|.:|:|...|.|
Human  1138 TPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQK 1202

  Fly   978 LYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVN 1042
            .:...|:||::|:...:.|:.||.:.::.||..||:.:.:....::.....|.::.......|.|
Human  1203 YFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAAN 1267

  Fly  1043 TTLGLWLDCV-SCIFLTSVTFSFIISSETTYS-GNVGLAIAQAMILTGMVQYGVRQVAESLQQMT 1105
            ..|.:.::.: :|:.|.:...|...|.....| |.|||.:..|::::..:.:.||.:|:...|:.
Human  1268 RWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLG 1332

  Fly  1106 SVERV--LQYTELEQ-EPALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKV 1167
            :|:|:  |..||.|. |..|.....|:.||.:|:::.:|:|.|||.:..|||:::|..|..|.|:
Human  1333 AVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKI 1397

  Fly  1168 GIVGRTGAGKSSLIGALFRLAH-IEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNL 1231
            ||.||||:||||...|.||:.. .||.|.||||:...:.|..||:|:|||.|||||||.|||:||
Human  1398 GICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNL 1462

  Fly  1232 DPFERYTDAELWSALEDVELR---KAIP-GLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVL 1292
            ||..:.:|:.||.|||..:|:   ||:| |||.::||.|.|||.|||||.|||||.:|...:.::
Human  1463 DPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIM 1527

  Fly  1293 DEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKS 1357
            |||||::|..|:.::|:.:...|...||:|:|||:||::.:|.:||:..|..:|||.|..||.:.
Human  1528 DEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1592

  Fly  1358 QGHLRQMVEA 1367
            .......|.|
Human  1593 DSVFASFVRA 1602

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5789NP_001247286.1 CFTR_protein 9..1367 CDD:273530 431/1438 (30%)
ABC_membrane 214..441 CDD:294371 69/254 (27%)
ABCC_MRP_domain1 495..699 CDD:213217 86/249 (35%)
ABC_membrane 863..1088 CDD:294371 66/237 (28%)
ABCC_MRP_domain2 1135..1350 CDD:213211 108/219 (49%)
ABCC8XP_016873686.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.720

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