DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5789 and abcc12

DIOPT Version :9

Sequence 1:NP_001247286.1 Gene:CG5789 / 42928 FlyBaseID:FBgn0039207 Length:1402 Species:Drosophila melanogaster
Sequence 2:XP_009301629.1 Gene:abcc12 / 568482 ZFINID:ZDB-GENE-050517-25 Length:1368 Species:Danio rerio


Alignment Length:1427 Identity:457/1427 - (32%)
Similarity:740/1427 - (51%) Gaps:195/1427 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 TRKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSH 72
            :..:|...|...|...|:|..|:::|..|..|:.|.|. ....|.:...|:|.:..|.:|:.|..
Zfish    64 SNSHPVDDAGFFSFTSFSWMTPMMWRLFRNRLDEDSLF-LSPHDGAHINGERFQRLWDEEVARVG 127

  Fly    73 RKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDIS 137
            .:|                                   |.|:.::::||||              
Zfish   128 LEK-----------------------------------ASLSAVIMRFQKT-------------- 143

  Fly   138 ISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILD 202
                     |.|.:::.|...|       .|:|      .||...:...:..|:.:..:      
Zfish   144 ---------RFIVSFLASVMFA-------FAVF------VGPSILVYEILNYVEQSEPS------ 180

  Fly   203 QTVEHMWNDMNSLGAVLVL-----STLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMK 262
             ||.|      .:|..:.|     |..|...:|..|:||   ...|::.|...|.::|.  :|::
Zfish   181 -TVVH------GVGVCVALFLTEFSKAFFASVLWAVNLR---TAVRVKGAFSMLAFKKI--ISLR 233

  Fly   263 TAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAML----TCYLIWLNIGIPAIVGVVGLL 323
            :......|..||:|::|..||....||..::..:|:..::    .|::    :|..|::|::..|
Zfish   234 SLTTITVGETINVLTSDGYRLFDAVIFGTFLLCVPVLLIICIIYACFI----LGYTALIGILVYL 294

  Fly   324 LKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQ 388
            : .:|:|.:::::..|.|.|....||.||..|||::..|::|||||||:.|:..:.:.|::|...
Zfish   295 I-FLPIQFSIARLIGVFRRRAVSVTDKRVRTMNEVLTCIKLIKMYAWEESFEKSITDIRKNEKLL 358

  Fly   389 IRYASYLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVS 453
            ::.|.|::....|...........:|......:...:.....::..:.:|.:::...: .|.:|.
Zfish   359 LQKAGYVQSLNSSLTTIVPTLATIVTFIVHTSLKLPLLPSTAYTIIAVFNCMRMSMGL-LPFSVK 422

  Fly   454 FGAEALVSLRRIQDFLMLEGREERTQG-LTHKRDQEGGDSRAVTIKDINASWD----------IE 507
            ..|||.|:|.|::..:::    :..:| ||..::.:    .|:.::....||.          .|
Zfish   423 AVAEAKVALTRLKRIMLV----QNPKGYLTQDKNMD----LALVMEKATFSWSPTDDKNTSQMPE 479

  Fly   508 KP----------QKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSY 562
            .|          |.:|::|:|.:.||.|..|.|.||:||:|::..:|.::.::.|.|...|.|:|
Zfish   480 NPSQNGKHKAESQPSLRNISLTLSKGSLLGVCGNVGSGKTSLISSILEQMHLLSGSVSANGTLAY 544

  Fly   563 AAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRAR 627
            .:|:.|:|.|:||:|||.||.||..||..|...|.|..|...||.||:|.:||||.:|||||:.|
Zfish   545 VSQQAWIFHGTVRDNILMGEPFDEARYASVINACCLKPDLAILPYGDQTEIGERGINLSGGQKQR 609

  Fly   628 ISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKA-TRILVTHQVHFLSEADV 691
            :|||||||....|:|:||||||||||||:|:|:|.|     ..:||. :.||||||:.:|...|.
Zfish   610 VSLARAVYSNRDIFLLDDPLSAVDAHVGKHIFEECI-----KKELKGKSVILVTHQLQYLEFCDE 669

  Fly   692 IVIVDQGRILRQGTYQELINSDLDFARLLERPKEEEEGE--NSRNQTSPLSVNSLESDDEDIPFI 754
            ::::|.|.|...||:.:|:.:...:::|:.....|:..|  :|:.||..   |..|..:.|.|..
Zfish   670 VMLLDNGEIKEAGTHSDLMKTKGRYSQLITNVHLEQNNERADSKPQTEH---NDSEQTNPDEPKA 731

  Fly   755 DGV----------KDGYQQLRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISPRVWYEYF 809
            :|:          |....:..|.||...|.|           |:....|....|.::.|.:::|.
Zfish   732 NGIENPAFDMSDEKPATNETPKDSSETKGKK-----------DQLVTREVAQEGSVTWRTYHQYC 785

  Fly   810 HAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIW-----TQQEHQRSQGEATFS----------TF 859
            .|....:    ::|::|:...:...|..|:|.|     .|.....|...||.:          :|
Zfish   786 QAAGGYI----LLFLVVLLFTLLVGSTAFSNWWLSYWLDQGSGNNSSSNATSNSGNISENPDLSF 846

  Fly   860 ECMYIYGALIIAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSK 924
            ..| :||.:|||:::::..:|:.|.|:.:.:|..|||.||..||.:.|.||||||:||::|||||
Zfish   847 YQM-VYGVIIIAMIVLSILKGYTFTKVTLRSSSKLHDTMFKRILGSPMSFFDTTPTGRLVNRFSK 910

  Fly   925 DMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRL 989
            |...:|.:||..|.:|:|..|::...|:.|.|:.|.|:.|::::.::...||.::.|..:.:||:
Zfish   911 DQDEVDAVLPFNMENFLQFCLIVTFTLLTICIVFPFLLIAVVILGLIFATILYVFQRSIRHMKRM 975

  Fly   990 EGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSC 1054
            |.:.|||..|..::::.||:.|.:...:....:.|.:|.|.:|:.:.|..|....|..|||.:|.
Zfish   976 ENVSRSPWISLTTSTIQGLSTIHAYDKRQQYIERFKMLSDNNSNHFMLFNAGTRWLSFWLDVLSA 1040

  Fly  1055 IFLTSVTFSFIISSETTYSGNV-GLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTE--L 1116
            .....|:...::|...|.:.:: |||::..:.|||::|:.||...|...:.|||||:|:|..  :
Zfish  1041 TVTLIVSLFVVLSPNETINPSLKGLALSYTIQLTGILQFVVRLSTEVEAKFTSVERLLEYITSCV 1105

  Fly  1117 EQEP-ALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSL 1180
            .:.| .:.:...|..||..|.:.|:|.|.||..|...||.|||:||..|.|:|||||||:|||||
Zfish  1106 SEGPRRVKDANIPAGWPQEGTITFKNYSMRYRDNTPIVLDNLNITIRPGEKLGIVGRTGSGKSSL 1170

  Fly  1181 IGALFRLAH-IEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWS 1244
            ..||||||. .||.|.||.::...:.|:.||:::|:||||||||..|:|||||||..|.|.|||.
Zfish  1171 GVALFRLAEPAEGTILIDDMDICKLGLKDLRSQLSVIPQDPVLFIGTVRYNLDPFNNYKDEELWL 1235

  Fly  1245 ALEDVELRKAI----PGLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDA 1305
            |||...::..|    ..|...|.|.|.|||||:|||:|:|||:|||:|:::||||||::|.:||:
Zfish  1236 ALEKTYMKDTISKLPEKLQSPVVENGENFSVGERQLMCMARALLRNSKIILLDEATASIDSETDS 1300

  Fly  1306 LIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEA 1367
            |||.|||..|:.||:||:|||::||::||||:|||.|..:|||.|..|:::.......::.|
Zfish  1301 LIQHTIRDGFQHCTMLTIAHRINTVLESDRILVMDQGKVIEFDPPQDLIQRPNSLFASLLAA 1362

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5789NP_001247286.1 CFTR_protein 9..1367 CDD:273530 456/1424 (32%)
ABC_membrane 214..441 CDD:294371 56/235 (24%)
ABCC_MRP_domain1 495..699 CDD:213217 94/224 (42%)
ABC_membrane 863..1088 CDD:294371 75/225 (33%)
ABCC_MRP_domain2 1135..1350 CDD:213211 124/219 (57%)
abcc12XP_009301629.1 CFTR_protein 68..1366 CDD:273530 457/1423 (32%)
ABC_membrane 149..414 CDD:294371 66/300 (22%)
ABCC_MRP_domain1 457..677 CDD:213217 94/224 (42%)
ABC_membrane 809..1077 CDD:294371 86/268 (32%)
ABCC_MRP_domain2 1125..1345 CDD:213211 124/219 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
65.730

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