DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and abcc6a

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	XP_009300481.1	Gene:	abcc6a / 566555	ZFINID:	ZDB-GENE-050517-18	Length:	1507	Species:	Danio rerio

Alignment Length:	1452	Identity:	457/1452 - (31%)
Similarity:	708/1452 - (48%)	Gaps:	231/1452 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KPTRKN--PRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKEL 68
            |...||  |.|.|:.:|:::|.|...|:::|.|..|..:||....:||.||::...||::|  ..
Zfish   197 KAVHKNACPVQDASFLSKILFWWFSGLIFKGYRSPLQAEDLWSLREEDTSERIISDLEEEW--TA 259

  Fly    69 ERSHRKKQKPHLRNA------------LFR----------CFL-------GPTIINGLICFI-YI 103
            :|:..::|:.|:..:            |.|          |.|       ||..:.|.:|.| :.
Zfish   260 KRTKLQQQENHMSTSAALGSRLPDQAQLLRKIQKEQSSGFCLLRTLARSFGPYFLTGTLCLIVHD 324

  Fly   104 VIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDA 168
            |....:|.||: ||:.|.|
Zfish   325 VFMFSVPQVLS-LLLGFMK---------------------------------------------- 342

  Fly   169 LFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTL--------- 224
                  |:..||                            |........:.:||.|
Zfish   343 ------DEDTPL----------------------------WKGYFYATLMFLLSCLQSVFNHQYT 373

  Fly   225 FCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIF 289
            :.||          .:|.|::.|...|:|||:|.::.........|.::||:|.|..:|....::
Zfish   374 YTCF----------TVGMRVKTAVMGLVYRKSLVMNSSARRTCTVGEIVNLVSADTQKLMDFVVY 428

  Fly   290 MHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGI 354
            .:.:|:.|::..|..:.:|.::|..|:.|:..::. ..|:...:::..|.|:....:..|.||.:
Zfish   429 FNAVWLAPIEVTLCLFFLWQHLGPSALAGIATVIF-IFPLNGFIARKRSKLQEIQMKYMDGRVKL 492

  Fly   355 MNELVQGIQVIKMYAWEKPFQAVVAEARRSEIK-----QIRYASYLRGFYLSTMVFTERSTLYIT 414
            |||::.||:::|.|||||.|...|...|..|:|     ||.|:..|..|..|:.
Zfish   493 MNEILNGIKILKFYAWEKAFLEQVLGYREKELKTLKKSQILYSVSLASFNSSSF----------- 546

  Fly   415 LAAAALMG--------QTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFLML 471
            |.|.|:.|        ..:.|..:|.:.:..|||:...: ..|.|:|...:|||||:|:..||..
Zfish   547 LIAFAMFGVYVLIDDKNVLDAQKIFVSMALINILKTPLS-QLPFAMSTTMQALVSLKRLGKFLCQ 610

  Fly   472 -EGREERTQGLTHKRDQEGGDSRAVTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAG 535
             |.:.:.....:.|.|.:|     |...:...||..:.| ..|:.|::::..|.|.||:|.||:|
Zfish   611 DELKPDNVARESFKSDVDG-----VVFDNGTFSWSKDGP-PCLKRISVKVPCGSLVAVVGHVGSG 669

  Fly   536 KSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALST 600
            |||:|..:|||.....|.|.::|.::|..|:.|:...|:::|||||.|.....||.|...|||..
Zfish   670 KSSLLSAMLGETEKRSGTVSVKGSIAYVPQQAWIQNASLQDNILFGREKKESWYQRVLEACALLP 734

  Fly   601 DFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGP 665
            |...||.||.|.:||:|.:|||||:.|:|||||||:...:||:||||||||||||:|:|::||||
Zfish   735 DLDNLPAGDATEIGEKGLNLSGGQKQRVSLARAVYRKGDVYLLDDPLSAVDAHVGQHIFNKVIGP 799

  Fly   666 RGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLERPKEEEEGE 730
            :|.|..  .||:||||.:.||.:||:|:::..|.|..:|:||||:|.:..||..:......|..|
Zfish   800 KGILRD--KTRVLVTHGMSFLPQADLILVLVDGEISERGSYQELLNRNGAFADFIHTFANSERKE 862

  Fly   731 --------NSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVHG-SKSLDSTQLDDNV 786
                    .||.... |||........|:              .|...:.| :.|:....|.|:
Zfish   863 CFSEALQRGSRKSVR-LSVTDYMPFSRDL--------------SQEQLIGGDTNSIAIEPLPDS- 911

  Fly   787 DEDDLAEAQAS---------GGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIW 842
            |||.:.|....         |.:...::.|||......|..| :||:....|....|::::.::|
Zfish   912 DEDHIPEDLGKLTKVDKARIGRVKLEMYIEYFRTIGLPLIIS-IVFLYAFQQAASLSNNYWLSLW 975

  Fly   843 TQQEHQRSQGEATFSTFECMYIYGALIIAVVIMTTFRGFLFFKI-------CMHASKVLHDRMFA 900
            ..|.....   ...:|...:.:||||..|       :|...|..       |:.||:.||..:..
Zfish   976 ADQPVING---TQLNTDLKLGVYGALGFA-------QGISIFGTTVAISLGCIIASRHLHLDLLN 1030

  Fly   901 CILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAM 965
            .:||:.|.||::||||.:||||:|::.|||.::|..:...:.....:..:.|::.:..|.....:
Zfish  1031 NVLHSPMSFFESTPSGNLLNRFAKEIDAIDNMIPDGLKMMLSYFFKLTEVCIIVLMATPFAAVII 1095

  Fly   966 LVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDV 1030
            |.:..:...|...|:..|..|:|||.:.|||:::||:.::.|.::||:...|.......:...|.
Zfish  1096 LPMVFLYGFIQSFYVATSCQLRRLESVSRSPIYTHLNETVQGASVIRAFNEQSRFIMGANHKVDH 1160

  Fly  1031 HSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVR 1095
            :.:.:.........||:.|:.:....:.:.:...:::..|...|.||||::.::.:||.:.:.||
Zfish  1161 NQTAYFPRFIATRWLGVNLEFLGNGIVLAASILSVMAKGTLSPGMVGLAVSHSLQVTGFLSWIVR 1225

  Fly  1096 QVAESLQQMTSVERVLQYTELEQEPAL---GEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNL 1157
            ...:....:.|||||.:|.:..:|.|.   |...|| .||..|.:||::...:|.......|:.:
Zfish  1226 SWTDVENNIVSVERVKEYADTPKEAAWSIEGSSLPP-SWPQTGTIEFQDYGLQYRKGLELALKGI 1289

  Fly  1158 NLTIEAGWKVGIVGRTGAGKSSLIGALFR-LAHIEGEIFIDGIETGTISLEILRTRISIIPQDPV 1221
            ::.|....|:|||||||||||||...:|| |...:|||:||||....|.|..||:||:|||||||
Zfish  1290 SVHIHEREKIGIVGRTGAGKSSLALGIFRILEAAKGEIYIDGINIAEIGLHDLRSRITIIPQDPV 1354

  Fly  1222 LFSATIRYNLDPFERYTDAELWSALEDVELRKAI----PGLDYMVTERGGNFSVGQRQLLCLARA 1282
            |||.::|.|||||..|:|.|:|:|||...|:..:    ..|::..:|.|.|.|:|||||:|||||
Zfish  1355 LFSGSLRMNLDPFNAYSDEEVWNALELAHLKNFVSELPDKLNHECSEGGENLSLGQRQLVCLARA 1419

  Fly  1283 ILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEF 1347
            :||..||||||||||.:|.:||.|||.|||.:|:.|.|||:||||:|:||..::||||.|..||.
Zfish  1420 LLRKTKVLVLDEATAALDLETDTLIQSTIRSQFEDCAVLTIAHRLNTIMDYTKVIVMDKGHVVEM 1484

  Fly  1348 DVPYLLLKKSQGHLRQMVEATG 1369
            |.|..|:.| :|....|....|
Zfish  1485 DSPSNLIAK-RGQFYYMCREAG 1505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	455/1445 (31%)
		ABC_membrane	214..441	CDD:294371	62/248 (25%)
		ABCC_MRP_domain1	495..699	CDD:213217	95/203 (47%)
		ABC_membrane	863..1088	CDD:294371	59/231 (26%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	116/219 (53%)
abcc6a	XP_009300481.1	MRP_assoc_pro	5..1506	CDD:188098	457/1452 (31%)
		ABC_membrane	317..584	CDD:279056	77/369 (21%)
		ABCC_MRP_domain1	630..831	CDD:213217	95/203 (47%)
		ABC_membrane	955..1218	CDD:279056	66/272 (24%)
		ABCC_MRP_domain2	1267..1487	CDD:213211	116/219 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.730