DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and Abcb9

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_063928.2	Gene:	Abcb9 / 56325	MGIID:	1861729	Length:	762	Species:	Mus musculus

Alignment Length:	658	Identity:	166/658 - (25%)
Similarity:	304/658 - (46%)	Gaps:	114/658 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   792 AEAQASGGISPRVWYEYFH----------AGST---LLSFS--FMVFVMVMS--QVVCSSSDFFA 839
            |||...|.       |.||          :|:|   |||::  .:.|::..|  .:|.:..:.|.
Mouse   144 AEALEPGN-------EGFHGEGGAPAEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFL 201

  Fly   840 NIWTQQE-----HQRSQGEATFS-TFECMYIYGALIIAVVIMTTFRGFLFFKICMHASKVLHDRM 898
            ..:|.:.     .|:|..:.|.: ...|:...|:.:.|.:     ||.:|..:....:..|.:.:
Mouse   202 PYYTGRAIDSIVIQKSMDQFTTAVVVVCLLAIGSSLAAGI-----RGGIFTLVFARLNIRLRNCL 261

  Fly   899 FACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVI----GILNP 959
            |..::.....|||...:|.:::|.:.|...:.:|:.:.:..|::..:.:.|:::.:    ..|:.
Mouse   262 FRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINIFLRNTVKVTGVVVFMFSLSWQLSL 326

  Fly   960 VLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEF 1024
            |......::.:|..:..|.|.|.|::::  ..:.|:...:  ..:::.:..:||...::..|:.|
Mouse   327 VTFMGFPIIMMVSNIYGKYYKRLSKEVQ--SALARASTTA--EETISAMKTVRSFANEEEEAEVF 387

  Fly  1025 -DLLQDVH-----------SSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYSGNVG 1077
             ..||.|:           |.||      .:.|.|.:..||.::...   ..:||.:.: |||:.
Mouse   388 LRKLQQVYKLNRKEAAAYMSYVW------GSGLTLLVVQVSILYYGG---HLVISGQMS-SGNLI 442

  Fly  1078 LAIAQAMIL------TGMVQYGVRQVAESLQQMTSVERVLQYTELEQEPAL---GEKTPPQQWPT 1133
            ..|....:|      .|.|..|:      :|.:.:.|:|.::  ::::|.:   |...|..   .
Mouse   443 AFIIYEFVLGDCMESVGSVYSGL------MQGVGAAEKVFEF--IDRQPTMVHDGSLAPDH---L 496

  Fly  1134 RGQVEFRNMSCRY--DPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHIE-GEIF 1195
            .|:|:|.|::..|  .|: :.||:|::.::..|....:||.:|:||||.:..|.....:: |.:.
Mouse   497 EGRVDFENVTFTYRTRPH-TQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLQGGRVL 560

  Fly  1196 IDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLD------PFERYTDAELWSALED--VELR 1252
            :||...|....:.|...||::.|:||||:.:|..|:.      |||...:|...:....  :||:
Mouse   561 LDGKPIGAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQ 625

  Fly  1253 KAIPGLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQ 1317
               .|......|:|...|.||:|.:.:|||::||..||:|||||:.:|.:::.|||:.|....::
Mouse   626 ---DGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQR 687

  Fly  1318 CTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHL------RQMVEATGGESEALK 1376
            .|||.:||||.||..:..|:|:|.|..|:......||  :||.|      |||:    |....|.
Mouse   688 HTVLIIAHRLSTVERAHLIVVLDKGRVVQQGTHQQLL--AQGGLYAKLVQRQML----GLEHPLD 746

  Fly  1377 KTASDSHK 1384
            .||  |||
Mouse   747 YTA--SHK 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	159/639 (25%)
		ABC_membrane	214..441	CDD:294371
		ABCC_MRP_domain1	495..699	CDD:213217
		ABC_membrane	863..1088	CDD:294371	45/246 (18%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	76/225 (34%)
Abcb9	NP_063928.2	3a01208	44..734	CDD:273363	156/632 (25%)
		ABC_membrane	189..451	CDD:279056	51/280 (18%)
		ABCC_TAP	489..714	CDD:213215	77/231 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000