DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5789 and Abcb10

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_062425.1	Gene:	Abcb10 / 56199	MGIID:	1860508	Length:	715	Species:	Mus musculus

Alignment Length:	633	Identity:	160/633 - (25%)
Similarity:	269/633 - (42%)	Gaps:	160/633 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   819 SFMVFVMVMSQVVCSSSDFFAN-----IWTQQEHQRSQGEATFST-----FECMYIYGALIIAVV 873
            |..|..:.:|.|:..|:.||..     |:|..    |:|.....|     ..|:::.||....:
Mouse   137 SAAVGFLAVSSVITMSAPFFLGRIIDVIYTNP----SEGYGDSLTRLCAVLTCVFLCGAAANGI- 196

  Fly   874 IMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAI--------- 929
                 |.:|...........|...:|:.||...:.|||.|.:|.::||.|.|...:
Mouse   197 -----RVYLMQSSGQSIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLS 256

  Fly   930 DELLPRA-------MMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQD-- 985
            |.|...|       ||.|:..:|..|    |:.::.|:     .|:||:....|:...:.:||
Mouse   257 DGLRAGAQASVGVGMMFFVSPSLATF----VLSVVPPI-----SVLAVIYGRYLRKLSKATQDSL 312

  Fly   986 ---------------------------------------LKRLEGICRSPVFSHLSASLTGLAII 1011
                                                   |.:.|.:.|:..|.  :|.|:|..|:
Mouse   313 AEATQLAEERIGNIRTIRAFGKEMTEVEKYTGRVDQLLQLAQKEALARAGFFG--AAGLSGNLIV 375

  Fly  1012 RSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYSGNV 1076
            .|     |:.|...|:...|.:|.:|:                        ||::     |:..|
Mouse   376 LS-----VLYKGGLLMGSAHMTVGELS------------------------SFLM-----YAFWV 406

  Fly  1077 GLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQEP--------ALGEKTPPQQWPT 1133
            ||:|.      |:..:    .:|.::.:.:..|:.:.  ||::|        .|.|||      .
Mouse   407 GLSIG------GLSSF----YSELMKGLGAGGRLWEL--LERQPRLPFNEGMVLDEKT------F 453

  Fly  1134 RGQVEFRNMSCRYD--PNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-IEGEIF 1195
            :|.:||||:...|.  |..| |.::.:|:|.:|....:||.:|:|||:::..|.||.. ..|.:.
Mouse   454 QGALEFRNVHFTYPARPEVS-VFQDFSLSIPSGSVTALVGPSGSGKSTVVSLLLRLYDPNSGTVS 517

  Fly  1196 IDGIETGTISLEILRTRISIIPQDPVLFSAT----IRYNLDPFERYTDAELWSALE---DVELRK 1253
            :||.:...::...||::|..:.|:|||||.:    |.|..|.....|..::..|.|   ..|..:
Mouse   518 LDGHDIRQLNPVWLRSKIGTVSQEPVLFSCSVAENIAYGADNLSSVTAQQVERAAEVANAAEFIR 582

  Fly  1254 AIP-GLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQ 1317
            :.| |.|.:|.|:|...|.||:|.:.:|||:|:|.|:|:|||||:.:|.:.:.|:|..:....:.
Mouse   583 SFPQGFDTVVGEKGILLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEHLVQEALDRLMEG 647

  Fly  1318 CTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMV 1365
            .|||.:||||.|:.:::.:.|:|.|...|......||.|..|..|:::
Mouse   648 RTVLIIAHRLSTIKNANFVAVLDHGKICEHGTHEELLLKPNGLYRKLM 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	160/633 (25%)
		ABC_membrane	214..441	CDD:294371
		ABCC_MRP_domain1	495..699	CDD:213217
		ABC_membrane	863..1088	CDD:294371	55/281 (20%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	77/225 (34%)
Abcb10	NP_062425.1	3a01208	8..694	CDD:273363	160/630 (25%)
		ABC_membrane	142..403	CDD:279056	61/315 (19%)
		ABC_MTABC3_MDL1_MDL2	458..698	CDD:213216	81/239 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000