DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and cftr

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_001038348.1	Gene:	cftr / 559080	ZFINID:	ZDB-GENE-050517-20	Length:	1485	Species:	Danio rerio

Alignment Length:	1595	Identity:	433/1595 - (27%)
Similarity:	734/1595 - (46%)	Gaps:	321/1595 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHR 73
            :::|.:.||.:|:..|.|..|::.:|.:..|...|:.|...:|.::.|.:|||.:|.:|:...
Zfish     2 QRSPVEDANCLSRYFFWWTNPIMRKGFKEKLRPSDVYQAPSQDAADILAERLEKEWDREVASG-- 64

  Fly    74 KKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISI 138
             |:||.|..|:.||::.|.::.|.:.:|....||:.|.:|.:::..|.  |..:....:...::.
Zfish    65 -KKKPSLLRAMARCYIKPFLLFGFLLYIGEATKTVQPQLLGRIIASFD--PAHEPERANGYFLAF 126

  Fly   139 SDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQ 203
            ...|..|||    ::|                            :||.:
Zfish   127 GLGLLFTAR----FLL----------------------------LQPAM---------------- 143

  Fly   204 TVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKTAGQTP 268
                                    |.|||       :|.::|||..|:||:|||:||.:...:..
Zfish   144 ------------------------FGLHH-------LGMQIRIALFSIIYKKTLKLSSRVLDKIS 177

  Fly   269 AGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTAL 333
            .|.|::|:|.::.:.|......|:|||.|||.:|...|||..|.:.:...:..:.|..| :|..|
Zfish   178 TGQLVSLMSANLGKFDQSLGMAHFIWISPLQCILCTGLIWELIDVNSFCALAAISLLGV-LQAFL 241

  Fly   334 SKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRGF 398
            |......:.:....|:.|:.:.:|:::.:..:|.|.||:..:.::...|:.|:|..|....||.|
Zfish   242 SHKMGPYKAQKVLLTNKRLALTSEIMENLHSVKAYGWEEIMETLIKNIRQDEVKLTRKIGSLRYF 306

  Fly   399 YLSTMVFTERSTLYITLAAAA--LMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVS 461
            |.|...|   |.:::.:||..  .:.:.|....:|:..||..:|::......|.::....:.:..
Zfish   307 YSSAYFF---SAIFVIVAAVVPHALSRGINLRRIFTTLSYCMVLRMTVTRQLPGSIQMWYDTMRL 368

  Fly   462 LRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINASWD---------IEKPQK------ 511
            :.:|::||   .:||      :|..:.......:.::|:.||||         |::..|
Zfish   369 IWKIEEFL---SKEE------YKLMEYDLSITELELQDVTASWDEGPGELLERIKQENKANGHHN 424

  Fly   512 --------------TLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSY 562
                          .|:.|:|:::||::.||.|.:|:||||:|..:||||....|.:...|.:||
Zfish   425 GDAGLFFTNLYVAPVLKDISLKLKKGEMLAVTGSMGSGKSSLLMTILGELVPSSGKIRHSGRISY 489

  Fly   563 AAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRAR 627
            ::|..|:..|::|:|||||..:|..||:.|.:.|.|..|...||..|||.:.|.|.:|||||:||
Zfish   490 SSQTAWIMPGTIRDNILFGLTYDEYRYKSVVKACQLEEDLAALPEKDKTPMAEGGLNLSGGQKAR 554

  Fly   628 ISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKA--TRILVTHQVHFLSEAD 690
            ::||||||:.|.:||:|.|.:.:|....:.:||:.      |.:|.|  ||||||:::..|..||
Zfish   555 VALARAVYRDADLYLLDAPFTHLDIATEKEIFDKC------LCKLMASKTRILVTNKIEHLKRAD 613

  Fly   691 VIVIVDQGRILRQGTYQELINSDLDFARLL-----------ER------------PKEEEEGENS 732
            .|:::..|.....||:.||.:...||:.||           ||            ..:|..|...
Zfish   614 KILLLHNGESFFYGTFPELQSERPDFSSLLLGLEAYDNISAERRCSILTETLHRVSVDESAGMQP 678

  Fly   733 RNQ-------TSPLSVN------------------------------------SLESDDE----- 749
            ...       |.|:.::                                    ||..::|
Zfish   679 ERSAFRQVPPTKPMYIDERKASVIVNPLGVARKASFIQVPEEEVRRTLPDRKFSLVPENELVDES 743

  Fly   750 ----DIPFIDGVKDGYQQLRK-----------------QSS-----------------SVHGSKS 776
                |:....||....|:.:.                 |||                 .::..:.
Zfish   744 FMGSDVYHNHGVHMAGQRRQSVLAFMTNAQGQGRREHLQSSFRRRLSVVPQSELASELDIYTRRL 808

  Fly   777 LDSTQ------LDDNVD---EDDLAEAQASGGISPRVWYEYFHAGSTLLSFSF-MVFVMVMS--Q 829
            .|||.      .::|::   .|::.|.:.:  .....|..|....|...|..: ::|::.::  :
Zfish   809 SDSTYDMTGILEEENIEACLTDEIDEIEET--FETTKWNTYVRYVSNNKSLLYVLIFILFIAAIE 871

  Fly   830 VVCSSSDFFA---NIWTQQEHQRSQGEAT------------------FSTFECMYIYGALIIAVV 873
            :..|.:..|.   .:| ::|||||:...|                  .|::..:|||.|...:::
Zfish   872 IAGSVAGIFLITDELW-REEHQRSEPNMTKHSNASSSGQTYAITVTPTSSYYILYIYVATSESLL 935

  Fly   874 IMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMM 938
            .|..|||..|....:..||.||.:|...:|.|.|...:|..:|||:|||:|||..||::||..|.
Zfish   936 AMGFFRGLPFVHTTITISKKLHQKMLHAVLSAPMSVLNTMKTGRIMNRFTKDMATIDDMLPLLMF 1000

  Fly   939 DFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSA 1003
            ||:|:.:|:.|.::|:.|:.|.:..|...:|::.:::.|.:||..|.||:||...|||:||||..
Zfish  1001 DFVQLTVVVVGCILVVSIVRPYIFLAATPLAIIFIVMRKYFLRTGQQLKQLETEARSPIFSHLIM 1065

  Fly  1004 SLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISS 1068
            ||.||..||:.:.|......|....:.|::.|.|.:   :||..:|.....:|:...|.:..|:.
Zfish  1066 SLKGLWTIRAFERQAYFEALFHKTLNTHTATWFLYL---STLRWFLFRADILFVFFFTLAAWIAV 1127

  Fly  1069 ETTYS--GNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQE---PALGEKT-- 1126
            .|...  |.:|:.|..||::.|..|:.|.........|.||:||.::.:|..|   |..|:.:
Zfish  1128 GTNQDKPGEIGIIICLAMLILGTFQWCVATSIAVDGMMRSVDRVFKFIDLPSETPKPDKGKDSDL 1192

  Fly  1127 --------PPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGA 1183
                    ....||.|||:|.||::.:|...|..||:||:.:.|...:|||:||||:|||||..|
Zfish  1193 IIENVDAQADSSWPHRGQIEVRNLTVKYTEAGHAVLKNLSFSAEGRQRVGILGRTGSGKSSLFNA 1257

  Fly  1184 LFRLAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALED 1248
            |.:|.:.:|||.|||:....:.|:..|....::||...:|:..:|.||||:..::|.|||...|:
Zfish  1258 LLKLVYTDGEISIDGVNWNKMPLQKWRKAFGVVPQKVFIFTGPLRMNLDPYGCHSDEELWRVAEE 1322

  Fly  1249 VELRKAI----PGLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQR 1309
            |.|:..|    ..||:.:...|...|.|.:||:||||:||...::|:|||.:|::||.|..::::
Zfish  1323 VGLKTVIEQFPDKLDFQLEYGGYVLSNGHKQLICLARSILSGARILLLDEPSAHLDPVTIKVLKK 1387

  Fly  1310 TIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEATGGESEA 1374
            |:|..|..||:|...|::..:::....::||.|....:|....||.:: .||:|.:    ..:|.
Zfish  1388 TLRQSFSTCTILLSEHKVEPLLECQSFLMMDKGQVKTYDSIQKLLNET-SHLKQAI----SPAER 1447

  Fly  1375 LK-------------KTASDSHKRMQRERDERDRD 1396
            ||             ...|...:.:|.|.::..:|
Zfish  1448 LKLFPRRNSSMRTPQSKLSSVTQTLQEEAEDNIQD 1482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	426/1551 (27%)
		ABC_membrane	214..441	CDD:294371	62/228 (27%)
		ABCC_MRP_domain1	495..699	CDD:213217	86/234 (37%)
		ABC_membrane	863..1088	CDD:294371	80/226 (35%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	83/218 (38%)
cftr	NP_001038348.1	AAA	1..1485	CDD:333001	433/1595 (27%)
		Disordered R region. /evidence=ECO:0000250\|UniProtKB:P13569	653..826		20/172 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1452..1485		4/31 (13%)
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:P13569	1483..1485		433/1595 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920