DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and abcc8

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	XP_005170744.1	Gene:	abcc8 / 553281	ZFINID:	ZDB-GENE-050517-22	Length:	1594	Species:	Danio rerio

Alignment Length:	1471	Identity:	429/1471 - (29%)
Similarity:	693/1471 - (47%)	Gaps:	264/1471 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 SHRKKQKP--HLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDV 133
            :|..:.||  .|::...| ||.| .:|.|....|..:.|.|.:.        .:.|:
Zfish   212 AHATEVKPPEDLQDLGVR-FLQP-FVNLLSKSTYWWMNTFITSA--------HRRPI-------- 258

  Fly   134 NDISISDSLNRTARAIPNYV-LSQAVANSSGSPGDA--------------LFPKS---------- 173
             |:.:...|....||:.||: |.||.....| |.|.              .|.|.
Zfish   259 -DLKVIGRLPIAMRALTNYIKLRQAFEAQKG-PQDTPPQGSKWIWAALRQAFGKPLILSITYRFM 321

  Fly   174 ---LDKAGPLEPIQPPVEEVDHNATAVRSILDQTVEHMW------NDMNSLGAVLVLSTLFCCFL 229
               |..||||     .:..:.|:.:.....:...|:|:.      .:..:.|.||.: .||...|
Zfish   322 ADLLGFAGPL-----CISGIVHHLSKENHTILPPVKHLGMYFISSQEFLANGYVLAV-LLFFALL 380

  Fly   230 LHHVDLRQRL-----MGARMRIACCSLIYRKTLRL---SMKTAGQTPAGYLINLLSNDVNRLDYG 286
            |....|:...     .|..:|.|..:.|:.|.:||   ::...|.| .|.:.||::.|.|:|.:.
Zfish   381 LQRTFLQASYYVAIETGINLRGAIQTKIFNKIMRLCTSNLSMGGMT-VGQICNLVAIDTNQLMWF 444

  Fly   287 FIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVG--VVGLLLKTVPVQTALSKVTSVLRMRIAERTD 349
            |.....::.||:|.::...|::..:||.|::|  ::.||   .|||..::...|..:....|.:.
Zfish   445 FFLCPNLFAMPVQIIVGIILLYYLLGISALIGATIITLL---APVQYFVATKLSDAQKSTLEYSS 506

  Fly   350 ARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRGFYLSTMVFTER----ST 410
            .|:...|||::||:::|:||||..|.:.|.|.|..|:..::..:    .|.|..:|...    :.
Zfish   507 ERLKKTNELLRGIKLLKLYAWEHIFCSNVEETRCKELTSLQAFA----LYTSISIFMNTAIPIAA 567

  Fly   411 LYITLAAAALMGQ--TITADFVFSAASYYNILQ----LVAAIWYPLAVSFGAEALVSLRRIQDFL 469
            :.:|..|...:..  .::....|::.|.::||.    |::::     |....:||||::::.:|.
Zfish   568 VLVTFVAHVHLSDDADLSPAVAFASLSLFHILVTPLFLLSSV-----VRSTVKALVSVQKLSEFF 627

  Fly   470 MLE---GREE-------------RTQGL-----THKR-------------DQEG-----GDSRAV 495
            ..:   |.:|             :.|.|     ..||             :||.     || ..:
Zfish   628 SCDEIGGEQEPRATVVPNSTNHNKYQALPLKVVNRKRPVREDWNSFALQSEQEDEVLAVGD-EDI 691

  Fly   496 TIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVF----- 555
            .||..|..:...:...||.::|::|..|||..::|.||.||||:|...|||:..|.|.|.
Zfish   692 CIKITNGYFSWTEGTSTLSNVNIKIPFGQLTMIVGQVGCGKSSLLLAALGEMQKISGTVIWNRMP 756

  Fly   556 --------------IQGDL------SYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALST 600
                          .:||:      :||:|:|||...::..||.|.....::||:.|...|:|..
Zfish   757 TLDAEGNESLPDAAAEGDIRKRGAVAYASQKPWLLNTTLAENITFEMPLIKQRYRAVIEACSLQP 821

  Fly   601 DFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGP 665
            |...||.||:|::||||..||||||.|||:|||:|:...:..:|||.||:|.|:..||..|  |.
Zfish   822 DIDILPQGDQTIIGERGIILSGGQRQRISVARALYQTTNVVFLDDPFSALDIHLSDHLMQE--GI 884

  Fly   666 RGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLD----FARLLERPKEE 726
            ...|.:.|.|.::|||::.:|..||.|:.:..|.|..:||.:::..|..:    :..|:.|..:|
Zfish   885 LKLLREEKRTVVIVTHKLQYLPHADWIIAMKDGSIQTEGTLKDIQKSQPELFEQWKTLMHRQDKE 949

  Fly   727 EEGENSRNQTSPLSVNSL------------ESDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSLDS 779
            .|.|......:.|...:|            |.|:|:                        :||:|
Zfish   950 FEKETVDENMTVLERKNLRRAMYSREALKTEEDEEE------------------------ESLES 990

  Fly   780 TQLDDNVDEDDLAEAQASGGISPRVWYEYFHAGSTLLSFS--FMVFVMVMSQVVCSS----SDFF 838
            .      |:|:|::........|  |    .:..|.||.:  .::.::::||::..|    .|::
Zfish   991 D------DDDNLSQVMRHRATIP--W----RSCGTYLSSAGLLLLLLLLLSQLLKHSLLVAIDYW 1043

  Fly   839 ANIWTQQ---------EHQ----------RSQGEATFSTFECMYIYGALIIAVVIMTTFRGFLFF 884
            ...||.:         .|.          .|.....||...|:.|  .|.:|..:...:.|
Zfish  1044 LAHWTSKVITAKIDAAAHNCSLVQDIGFTHSSYLLVFSLLCCLGI--VLCLATSVAVEWTG---- 1102

  Fly   885 KICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFG 949
               :..:|.||..:.:.|:.|.||.|:|||.|.||||||.|...||:.:|..:....:..|:...
Zfish  1103 ---LRVAKELHHNLLSNIILAPMRLFETTPLGSILNRFSSDTNTIDQHIPATLECLSRSTLLCVS 1164

  Fly   950 ILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSR 1014
            .|.||..:.||.:..:..:.:....|.|.:...|:||::||...:.|:.||.|.::.||..||:.
Zfish  1165 ALGVISYVTPVFLIVLAPLTIACYFIQKYFRVASKDLQQLEDSTQLPLLSHFSETVEGLTTIRAF 1229

  Fly  1015 QLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCV-SCIFLTSVTFSFIISSETTYS----G 1074
            :.:....:......|.::.......|.|..|.:.::.: :||.|.:...|.   :.:.||    |
Zfish  1230 RYEPRFRQRLLQFTDANNMASLFLTAANRWLEVRMEYIGACIVLIAAVASI---TNSLYSHLSTG 1291

  Fly  1075 NVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERV--LQYTELEQ-EPALGEKTPPQQWPTRGQ 1136
            .|||.:..|::::..:.:.||.:|:...|:.:|:|:  |..||.|. |..|.....|:.||.:|:
Zfish  1292 LVGLGLTYALMVSNYLNWMVRNLADMEVQLGAVKRIKALLRTEPENYEGLLSASQVPEGWPQQGE 1356

  Fly  1137 VEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-IEGEIFIDGIE 1200
            ::.:|:|.|||....|||:::|..|:.|.|:||.||||:||||...|.||:.. .||.|.||.|:
Zfish  1357 IQIQNLSVRYDSTLKPVLKHVNAHIKPGQKLGICGRTGSGKSSFSLAFFRMVDTFEGRIIIDDID 1421

  Fly  1201 TGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELR---KAIP-GLDYM 1261
            ...:.|:.||:|.|||.|||.|||.|||:||||..:.||:.||.|||..:|:   |.:| |||.:
Zfish  1422 IAKLPLQTLRSRFSIIQQDPFLFSGTIRFNLDPEMKATDSMLWEALEIAQLKPVVKTLPGGLDAI 1486

  Fly  1262 VTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHR 1326
            :||.|.|||.|||||.|||||.:|.:.:|::|||||::|..|::::|:.:...|...||:|:|||
Zfish  1487 ITEGGENFSQGQRQLFCLARAFVRKSSILIMDEATASIDMATESILQKVVMTAFADRTVVTIAHR 1551

  Fly  1327 LHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEA 1367
            :||::::|.:|||..||.:|||.|.:||.:........|.|
Zfish  1552 VHTILNADLVIVMKRGVILEFDKPEVLLDQEDSVFASFVRA 1592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	428/1469 (29%)
		ABC_membrane	214..441	CDD:294371	63/242 (26%)
		ABCC_MRP_domain1	495..699	CDD:213217	84/228 (37%)
		ABC_membrane	863..1088	CDD:294371	62/229 (27%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	109/219 (50%)
abcc8	XP_005170744.1	MRP_assoc_pro	39..1591	CDD:188098	427/1468 (29%)
		ABC_membrane	<388..603	CDD:294371	56/222 (25%)
		P-loop_NTPase	693..918	CDD:304359	84/226 (37%)
		ABC_membrane	1038..1307	CDD:279056	70/280 (25%)
		P-loop_NTPase	1355..1594	CDD:304359	114/238 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810