DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cftr and LOC4397657

DIOPT Version :10

Sequence 1:NP_651269.1 Gene:Cftr / 42928 FlyBaseID:FBgn0039207 Length:1402 Species:Drosophila melanogaster
Sequence 2:XP_061510127.1 Gene:LOC4397657 / 4397657 VectorBaseID:AGAMI1_001984 Length:1504 Species:Anopheles gambiae


Alignment Length:1440 Identity:468/1440 - (32%)
Similarity:737/1440 - (51%) Gaps:213/1440 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 AKPTRKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELE 69
            ||....||...::..|:|.:.:.....:||.|:.|..||:.....||.|..|....:..|::.:|
Mosquito   200 AKLKNPNPELRSSFFSRLFYLYFDSYAWRGFRKPLTDDDMYDLNPEDTSRALVPPFDKYWYESVE 264

  Fly    70 RSHRKK-------------QKPHLRN------ALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQ 115
            :..||:             .||:...      |:.:.:.||....|::.|....::...|.::.:
Mosquito   265 KGRRKQIAADKKAGKTNLVYKPNAATNGSVLPAMVKAYGGPFWFAGMLQFAISGLQFASPYLMQE 329

  Fly   116 LLIQFQKTPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPL 180
            ::                                       ||.             :||  || 
Mosquito   330 IM---------------------------------------AVI-------------ALD--GP- 339

  Fly   181 EPIQPPVEEVDHNATAVRSILDQTVEHMWNDM-NSLGAVL--VLSTLFCCFLLHHVDLRQRLMGA 242
                                       .|..| .:||..|  :|..||.....|    |..|:|.
Mosquito   340 ---------------------------FWKGMIITLGLFLTSLLIALFNGQYFH----RTFLVGF 373

  Fly   243 RMRIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLI 307
            |:|....|.||||.||:|......|..|.::||::.|..|......::|.:|..||...|..||:
Mosquito   374 RIRTGLISAIYRKALRISSFAKKDTTVGEIVNLMAVDAQRFFELTSYLHVLWSAPLIIALCIYLL 438

  Fly   308 WLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEK 372
            :..:| ||:...:|:::..:|:...::.....|::...:..|.||..|||::.||:|:|:||||.
Mosquito   439 YELLG-PAVFAGLGVMVIMIPITGFIATRMRDLQVEQMKIKDERVKKMNEILGGIKVLKLYAWEP 502

  Fly   373 PFQAVVAEARRSEIKQIRYASYLRG--FYLSTMVFTERSTLYITLAAAALM-----GQTITADFV 430
            .||..|...|..|:..::.|:|...  :::.||     :...:|||:.|:.     ...:.....
Mosquito   503 SFQDTVVTVRNEELDVLKSAAYYGAGTYFVWTM-----APFLVTLASFAVYVMIDEENVLDPQTA 562

  Fly   431 FSAASYYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAV 495
            |.|.:.:|||:...|: :|:.::|..:|.||::||..|:..|  |.....:||.:.:     .|:
Mosquito   563 FVALALFNILRFPLAM-FPMMITFAMQAWVSIKRIDKFMNSE--ELDPNNVTHNKSE-----NAL 619

  Fly   496 TIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDL 560
            .:||...||..:.|  ||::|||.:.:|:|.||:|.||.||||::..||||:..:.|.|...|.:
Mosquito   620 EVKDGTFSWGDDAP--TLKNINLALRRGKLSAVVGGVGTGKSSLISALLGEMEKMKGSVNTDGSI 682

  Fly   561 SYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQR 625
            :|..|:.|:...::|:|||||..||:.:|.:|..||||..|.:.||.||.|.:||:|.:|||||:
Mosquito   683 AYVPQQAWIQNATLRDNILFGRPFDQAKYDKVIECCALRPDLEMLPGGDTTEIGEKGINLSGGQK 747

  Fly   626 ARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEAD 690
            .|::||||||..:::||.||||||||||||:|:|::||||.|.|  :..:|:||||.:.||...:
Mosquito   748 QRVALARAVYADSEVYLFDDPLSAVDAHVGKHIFEKVIGPSGML--VGRSRLLVTHGISFLPFVE 810

  Fly   691 VIVIVDQGRILRQGTYQELINSDLDFARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFI- 754
            .|.::..|.:...|:||||::....||..|.:..:|.:.|                |::::..| 
Mosquito   811 EIFVMKDGEVSESGSYQELLDQKGAFAEFLTQHIQEMDDE----------------DEDELKLIQ 859

  Fly   755 DGVKDGYQQLRK-----------QSSSVHGS---------KSLDSTQ---LDDNVDEDDLA---- 792
            :.:|||  :.:|           :|.|.:||         :|.:|.:   ::..|.:...|    
Mosquito   860 EALKDG--EAKKIVQRAMSTRSQRSGSSNGSVRKKRVSRAESRNSNKPRAVEQTVAQQSSATLIE 922

  Fly   793 -EAQASGGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQQEHQRSQGEATF 856
             |..|:|.:...|:.:||......|.| :.:|..|::|    .:..:||||.....:..:. ||.
Mosquito   923 KEESATGAVGYVVYIKYFKGIGLWLGF-WSIFFSVINQ----GASIYANIWLTDWSEDPEA-ATD 981

  Fly   857 STFECMY--IYG--------ALIIAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFD 911
            .:...||  :||        ||:||.|.:...        |:.|::.||:.:....:...|.|||
Mosquito   982 PSVRDMYLGVYGGLGGAQSIALLIASVTLALG--------CIKAARELHNNLLESSMRMPMSFFD 1038

  Fly   912 TTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLIL 976
            |||.|||:||||||:..:|.:||:::..::.:...:.|:.:||||..|:.:|.:....|:..||.
Mosquito  1039 TTPLGRIMNRFSKDVDVVDNILPQSIRAWLLMFFNVIGVFVVIGISTPIFLAVVPAFLVIYYLIQ 1103

  Fly   977 KLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAV 1041
            |.|:..|:.|||||.:.|||::||...|:||.:.||:...|:....|.:...|.:......::..
Mosquito  1104 KFYIATSRQLKRLESVTRSPIYSHFGESITGQSTIRAYGQQERFMNESEQRVDYNQLTSYPSIIA 1168

  Fly  1042 NTTLGLWLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTS 1106
            |..|.:.|:.|..:.:.......:::.::.....|||:|:.|:.::..:.:.||..||....:.:
Mosquito  1169 NRWLAVRLELVGALVVFFAALFAMVARDSIGQATVGLSISYALQISATLSFLVRMTAEVETNIVA 1233

  Fly  1107 VERVLQYTEL--EQEPALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGI 1169
            :||:.:||.|  |.|..||.  ..:.||..|:|||::...||......|:|.::|.:..|.|:||
Mosquito  1234 IERLEEYTVLPREAEWQLGH--VDKAWPVEGKVEFKDYQIRYREGLDLVIRGISLNVRGGEKIGI 1296

  Fly  1170 VGRTGAGKSSLIGALFRLAHIE-GEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDP 1233
            |||||||||||...|||:.... |:|.|||::...:.|..||.|::||||||||||.|:|.|:||
Mosquito  1297 VGRTGAGKSSLTLGLFRIVEAAGGQIIIDGLDISKMGLHQLRGRLTIIPQDPVLFSGTLRANVDP 1361

  Fly  1234 FERYTDAELWSALEDVELRKAI----PGLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDE 1294
            |:.|:|..:|.|||...|:..:    .|||:.:.|.|.|.|||||||:|||||:||..|||:|||
Mosquito  1362 FKSYSDDLVWKALELSHLKTFVKGLAAGLDHEIAENGENLSVGQRQLICLARAVLRKTKVLILDE 1426

  Fly  1295 ATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQG 1359
            |||.||.:||.|||:|||.:|..||:||:||||:|::||||::|:|.|:..|.|.|..||...:.
Mosquito  1427 ATAAVDLETDDLIQKTIRTEFADCTILTIAHRLNTILDSDRVLVLDKGLVAECDSPQNLLANRES 1491

  Fly  1360 HLRQMVEATG 1369
            ....|.:..|
Mosquito  1492 IFFGMAKNAG 1501

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CftrNP_651269.1 MRP_assoc_pro 12..1356 CDD:188098 463/1418 (33%)
LOC4397657XP_061510127.1 None

Return to query results.
Submit another query.