DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and ABCC1

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	XP_016878726.1	Gene:	ABCC1 / 4363	HGNCID:	51	Length:	1549	Species:	Homo sapiens

Alignment Length:	1436	Identity:	488/1436 - (33%)
Similarity:	745/1436 - (51%)	Gaps:	193/1436 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKE--------- 67
            |...|:.:|::.|.|...|:.||.|:.|...||....|||.|||:...|...|.||
Human   227 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 291

  Fly    68 ---------------------------LERSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVI 105
                                       :.:|.:|:..|.|...|::.| ||..   |:.|.:..|
Human   292 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTF-GPYF---LMSFFFKAI 352

  Fly   106 KTLI----PAVLAQLLIQFQKTPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPG 166
            ..|:    |.:| :|||:|            |||
Human   353 HDLMMFSGPQIL-KLLIKF------------VND------------------------------- 373

  Fly   167 DALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLH 231
                .|:.|..|....:          ...|.:.|...|.|.:              ...||
Human   374 ----TKAPDWQGYFYTV----------LLFVTACLQTLVLHQY--------------FHICF--- 407

  Fly   232 HVDLRQRLMGARMRIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIM 296
                   :.|.|::.|....:|||.|.::......:..|.::||:|.|..|......:::.||..
Human   408 -------VSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSA 465

  Fly   297 PLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQG 361
            |||.:|..||:|||:| |:::..|.:::..|||...::..|...::...:..|.|:.:|||::.|
Human   466 PLQVILALYLLWLNLG-PSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNG 529

  Fly   362 IQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALMGQT-- 424
            |:|:|:||||..|:..|...|:.|:|.::.::||......|.|.|.......|.|....:.:.
Human   530 IKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNI 594

  Fly   425 ITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEG 489
            :.|...|.:.:.:|||:....| .|:.:|...:|.|||:|::.||..|  |.....:..:..::|
Human   595 LDAQTAFVSLALFNILRFPLNI-LPMVISSIVQASVSLKRLRIFLSHE--ELEPDSIERRPVKDG 656

  Fly   490 GDSRAVTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGV 554
            |.:.::|:::...:|....| .||..|...|.:|.|.||:|.||.||||:|..||.|:..::|.|
Human   657 GGTNSITVRNATFTWARSDP-PTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHV 720

  Fly   555 FIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGAS 619
            .|:|.::|..|:.|:...|:|.|||||.:.:...|:.|.:.|||..|.:.||:||:|.:||:|.:
Human   721 AIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVN 785

  Fly   620 LSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVH 684
            |||||:.|:|||||||..|.|||.||||||||||||:|:|:.||||:|.|.  ..|||||||.:.
Human   786 LSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLK--NKTRILVTHSMS 848

  Fly   685 FLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLER-PKEEEEGENSRNQTSPLSVNSLESDD 748
            :|.:.|||:::..|:|...|:||||:..|..||..|.. ...|:|.:...|..:.:|....|:..
Human   849 YLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQ 913

  Fly   749 EDIPFIDGVKDGYQQLRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQ-------------ASGGI 800
            .:...:.....|.|..|:.|||  .|.|.|.::..::..|...|||:             .:|.:
Human   914 MENGMLVTDSAGKQLQRQLSSS--SSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQV 976

  Fly   801 SPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQ-------QEHQRSQGEATFST 858
            ...|:::|..|....:|| ..:|:.:.:.|...:|:::.::||.       |||.:.:
Human   977 KLSVYWDYMKAIGLFISF-LSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVR------- 1033

  Fly   859 FECMYIYGALIIAVVIMTTFRGFLFFKICMH-------ASKVLHDRMFACILHATMRFFDTTPSG 916
               :.:||||.|:       :|...|...|.       ||:.||..:...||.:.|.||:.||||
Human  1034 ---LSVYGALGIS-------QGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSG 1088

  Fly   917 RILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLR 981
            .::|||||::..:|.::|..:..|:.....:.|..|||.:..|:....:..:.::...:.:.|:.
Human  1089 NLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVA 1153

  Fly   982 PSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLG 1046
            .|:.|||||.:.||||:||.:.:|.|:::||:.:.|:....:.||..|.:...:..::..|..|.
Human  1154 SSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA 1218

  Fly  1047 LWLDCV-SCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERV 1110
            :.|:|| :||.|.:..|: :||..:..:|.|||:::.::.:|..:.:.||..:|....:.:|||:
Human  1219 VRLECVGNCIVLFAALFA-VISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERL 1282

  Fly  1111 LQYTELEQEP--ALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRT 1173
            .:|:|.|:|.  .:.|..||..||..|:|||||...||..:...|||::|:||..|.||||||||
Human  1283 KEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRT 1347

  Fly  1174 GAGKSSLIGALFRL-AHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERY 1237
            |||||||...|||: ...||||.||||....|.|..||.:|:||||||||||.::|.|||||.:|
Human  1348 GAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQY 1412

  Fly  1238 TDAELWSALEDVELR---KAIPG-LDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATAN 1298
            :|.|:|::||...|:   .|:|. ||:...|.|.|.|||||||:|||||:||..|:||||||||.
Human  1413 SDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAA 1477

  Fly  1299 VDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQ 1363
            ||.:||.|||.|||.:|:.|||||:||||:|:||..|:||:|.|...|:..|..||:: :|....
Human  1478 VDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ-RGLFYS 1541

  Fly  1364 MVEATG 1369
            |.:..|
Human  1542 MAKDAG 1547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	487/1432 (34%)
		ABC_membrane	214..441	CDD:294371	62/228 (27%)
		ABCC_MRP_domain1	495..699	CDD:213217	98/203 (48%)
		ABC_membrane	863..1088	CDD:294371	70/232 (30%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	128/219 (58%)
ABCC1	XP_016878726.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.730