Protein Alignment Cftr and CG11898

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_651679.2
• Gene: CG11898 / 43451
• FlyBaseID: FBgn0039645
• Length: 1320
• Species: Drosophila melanogaster
• Alignment Length: 1459
• Identity: 520/1459 - (35%)
• Similarity: 777/1459 - (53%)
• Gaps: 216/1459 - (14%)

  Fly     1 MDSSAKPTRKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWF 65
            |.:..:..:.||...||..|:..|.|...:|.:|.:|.|:..||.:......|.|:...|...|.
  Fly     1 MSAVHEQRQPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWE 65

  Fly    66 KELERSHRKKQKPHLRNALFRC----FLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVA 126
            :||:||     ||::...:|:.    |:..:|:..::.   |.:.|..|.:|..|:..|
  Fly    66 QELKRS-----KPNVLRMIFKAYGWSFVPASIVYSIMA---IAVHTTQPLMLGGLVSFF------ 116

  Fly   127 QLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVD 191
                        |:|..:..:
  Fly   117 ------------SESTGKITK-------------------------------------------- 125

  Fly   192 HNATAVRSILDQTVEHMWNDMNSLGAVL--VLSTLFCCFLLHHVDLRQRL-MGARMRIACCSLIY 253
            |:|.                :.::|.||  ::|.||     .|..::... :|:|:|:||..|:|
  Fly   126 HSAY----------------LYAMGVVLCSLISGLF-----FHPFMKYLFRVGSRVRLACAGLVY 169

  Fly   254 RKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVG 318
            ||.||:|:.......:||.|:|::.|:...:..|...|.:|..||:.::..|:|:..||.||:||
  Fly   170 RKFLRVSVAADNSGVSGYAISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVG 234

  Fly   319 VVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARR 383
             :|.::..:|:|...::..:..:...|:..|.||.:|||::..:|:||||||||.|..::.:.|:
  Fly   235 -LGTIVAFIPLQAWAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRK 298

  Fly   384 SEIKQIRYASYL-RGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIW 447
            .|:..||.::|: .|...:.|:  .:.:|:::|......|..:|:..||..||||:.|.......
  Fly   299 EEMDSIRGSTYIYAGLQCTGMI--SKLSLFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHS 361

  Fly   448 YPLAVSFGAEALVSLRRIQDFLM------------LEGREERTQ-----GLTHKRDQEGGDSRAV 495
            :|||::...|..|...|::|||.            .:..|:..:     |.|||...|   .:::
  Fly   362 WPLAINMWVETFVVANRVKDFLFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAE---VKSI 423

  Fly   496 TIKDINASWDIEKPQKT---LQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQ 557
            |:..::||||.:|.:|.   ::.::.|.:..|...::|.||||||::||::||||.:|.|.|.:.
  Fly   424 TVHKLSASWDQKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVN 488

  Fly   558 GDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSG 622
            |.||||.|||||..||:|:||||.|.:|.:||.||.|.|.|..|.:|||.||.|.|||.||||||
  Fly   489 GVLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSG 553

  Fly   623 GQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLS 687
            ||:||:|||||||:.|.|||:||||||||:||.:.|.|..:..    ...|..||||||:|..|.
  Fly   554 GQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNE----FLSKKIRILVTHRVQLLR 614

  Fly   688 EADVIVIVDQGRILRQGTYQEL---------INSDLDFARL----LERPKEEEEGENSRNQTSPL 739
            ..|.:|:::.|||..||.|..|         :.:|::.|:|    .:...||.|...|.:|...:
  Fly   615 HVDHLVLLEGGRISVQGHYDALKKLIRFRMSVANDVEVAKLRAMRTDSVYEEPEPRKSLSQEEHM 679

  Fly   740 SVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISPRV 804
            ..:.:|                ||.::|                           |..|.:..:.
  Fly   680 DRHEIE----------------QQFKEQ---------------------------QQIGSVKLQT 701

  Fly   805 WYEYFHAGSTLLSFSFMVFVMVMSQVVCSSS----DFFANIW-TQQEHQRSQGEAT----FSTFE 860
            :.|||    .:|....:|.::::..||..||    |.|.:.| |.:|.:.:|.|..    .:...
  Fly   702 YKEYF----KVLGHPLVVVLILLMFVVARSSEATMDIFLSKWATWEETEPNQHEPIPEYHRTRLR 762

  Fly   861 CMYIYGALIIAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKD 925
            .|.:|..||:..:|....|.|.||.:.:..|..:||::|..::.|.|.||....|||||||||.|
  Fly   763 MMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSD 827

  Fly   926 MGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILK----LYLRPSQDL 986
            :.|||..||:||||.|:.|:....:|.|:...|    ..:|:.|.|.|.:|.    ||:..|:.|
  Fly   828 VLAIDVNLPQAMMDSIEFAVNALAVLAVVSTAN----IWLLIPATVVVALLYGCRCLYIGASRSL 888

  Fly   987 KRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDC 1051
            ||:|.|.|||::||.:|:..|||.||:......:.::|...|:.::|...|.:::|.....|.|.
  Fly   889 KRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYYQNENTSALYLHVSINRAFAFWTDL 953

  Fly  1052 VSCIFLTSVTFSFIISSETT--YSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYT 1114
            :..:::.:|||||::..:..  |||:|||||.|:|.|..|.|.|:||..|....|||||||::|.
  Fly   954 ICVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYV 1018

  Fly  1115 ELEQEPALGEKTP---PQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAG 1176
            .:..|||...:..   |:.||:.||::||::..||..:|..:|:.|..||....|:||||.|.||
  Fly  1019 NIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAG 1083

  Fly  1177 KSSLIGALFRLAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAE 1241
            |||::.||||||||.|.|.|||.||..:.|..||.|||||||||||||.::|:||||||..||.|
  Fly  1084 KSSIVHALFRLAHINGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEE 1148

  Fly  1242 LWSALEDVELRKAI----PGLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQ 1302
            ||.|||.|:|::.:    .|::..:.:.|.|||:|||||:|||||:||.||:|::|||||||||:
  Fly  1149 LWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPE 1213

  Fly  1303 TDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEA 1367
            ||.|||..|..||..|||||:|||||||||:||::|:|.|..||...|:.||....|:|.:.||.
  Fly  1214 TDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFVEK 1278

  Fly  1368 TG-GESEALKKTASDSHKRMQRERDERDR 1395
            || |.::.|:..|..|:::....|...|:
  Fly  1279 TGVGTAQHLRHLAEQSYRKRVLGRKSEDQ 1307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	506/1406 (36%)
CG11898	NP_651679.2	MRP_assoc_pro	2..1268	CDD:188098	507/1417 (36%)