Protein Alignment Cftr and rdog

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_651678.1
• Gene: rdog / 43450
• FlyBaseID: FBgn0039644
• Length: 1374
• Species: Drosophila melanogaster
• Alignment Length: 1462
• Identity: 555/1462 - (37%)
• Similarity: 812/1462 - (55%)
• Gaps: 208/1462 - (14%)

  Fly    10 KNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRK 74
            |||...||..||..|.|...|..||.:..|..::|.|..|...||::.::..:.|..||:||:
  Fly    12 KNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDELKRSN-- 74

  Fly    75 KQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISIS 139
               |.:...:.|.:       |         |..:|..||                     .|||
  Fly    75 ---PSVVRMILRAY-------G---------KIFVPMGLA---------------------FSIS 99

  Fly   140 DSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQT 204
            :::.:                       :|.|..|   |.|         |.:.||      :||
  Fly   100 ETICK-----------------------SLMPLFL---GGL---------VGYFAT------NQT 123

  Fly   205 VEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRL-----MGARMRIACCSLIYRKTLRLSMKTA 264
                  |::...|.|....:..|.|:..:.....:     :|.::|:|...|||||.|::|..::
  Fly   124 ------DISENTAYLYAMGIVICMLVPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSS 182

  Fly   265 GQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPV 329
            .....|..||:||||:.|.|....|:|..|..|::::|..:|::..|||.|::| |..:|..:|:
  Fly   183 NDGLRGRAINILSNDLGRFDVALCFLHDTWKGPMESILIGFLMYREIGISAVIG-VSFMLSFIPL 246

  Fly   330 QTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASY 394
            |...:|..:..|...|||||.||.:|||::|||||||||||||.|..|:||.|..|:|.||..:|
  Fly   247 QAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAY 311

  Fly   395 LRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEAL 459
            :......|.:.:..| :::.|.:...:|..:||..|::.:||:|:|......::|::::|.||||
  Fly   312 IHAALGCTSMISPLS-VFLALCSYVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEAL 375

  Fly   460 VSLRRIQDFLM----------LE-----GREER------------------TQGLTHK---RDQE 488
            ||.:|.:|||:          ||     |:.:|                  :.|..|.   ||.:
  Fly   376 VSAKRCKDFLLDGDKAEVPINLEANQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYD 440

  Fly   489 -GGDSRAVTIKDINASWDIEKPQK--TLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVI 550
             ....:.|.:|:::||||......  .::..:..|:...|.||:|||||||||.|.:||||:.:.
  Fly   441 PEATKKCVVLKNVSASWDTSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEVGID 505

  Fly   551 DGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGE 615
            .|...:.|.:|||:||.|:|.|::|:||:|.|:::.:||::|.:.|.|..|.:.||.||.|:|||
  Fly   506 KGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPRGDLTVVGE 570

  Fly   616 RGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVT 680
            ||.||||||:||:|||||||:.|.|||:||||||||.|||:|:||..|  |..|:  ...|||||
  Fly   571 RGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCI--RDFLS--NKIRILVT 631

  Fly   681 HQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLERPKEEEEGENSRNQTSPLSVNSLE 745
            |||.:|.:.:.::::..|:|:.||:||||..| ..| :.||:.:.:|.|.::.:.:|.||    .
  Fly   632 HQVQYLFDVEHLLLMGSGKIMAQGSYQELQRS-RQF-QFLEQTQHDESGIDTHSVSSYLS----R 690

  Fly   746 SDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISPRVWYEYFH 810
            ||.|     ..::..:.||.:.               |::| ||...|.|..|.|...|:..|..
  Fly   691 SDSE-----KSMEHQHNQLLRP---------------DEHV-EDVNQEQQTVGSIKMHVYASYIK 734

  Fly   811 AGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQQEHQRSQGEATF------STF---------- 859
            |..:......::.:.|.::::.:..|:|.:.|...|.|.:....|.      :|.
  Fly   735 ALDSTFLLGIVISLFVCARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINAT 799

  Fly   860 ------------------ECMYIYGALIIAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHAT 906
                              |.:..|..::.|.:|:...|.|.|||:|:..|..||||:|..|..|:
  Fly   800 DPYIAPLLASDIQAGIRQELVLFYATILGATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRAS 864

  Fly   907 MRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVV 971
            |.||:|..|||||||||||:..:|..||..::|.:...:.:.|::|::.|.|..|:....::.|:
  Fly   865 MYFFNTNSSGRILNRFSKDIRTVDTDLPHTLLDCLAFIIDVSGVVIIVAIANYWLLIPAAIIGVI 929

  Fly   972 DVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQ 1036
            ..:|..||:..|:.:||||.|.||||||..:.:..||..||:.|.|..:.:||...|:.::|.|.
  Fly   930 LGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWF 994

  Fly  1037 LTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESL 1101
            |.::......||.|.:..:::|:|||||::..:...||:|||||..:..:|||.|:|:||.||..
  Fly   995 LFLSCTRAFALWSDVLCIVYMTAVTFSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELE 1059

  Fly  1102 QQMTSVERVLQYTELEQEPAL--GEK-TPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEA 1163
            .|||||||||:|||...|..|  .|| .|..:||::|::||.|...||.|..:|||::||.|||.
  Fly  1060 NQMTSVERVLEYTEQPSEALLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEP 1124

  Fly  1164 GWKVGIVGRTGAGKSSLIGALFRLAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIR 1228
            ..|:||||||||||||:|.::||||..||.|.||.::...|.|..||:::|||||||||||.|:|
  Fly  1125 REKIGIVGRTGAGKSSIIQSIFRLACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLR 1189

  Fly  1229 YNLDPFERYTDAELWSALEDVELRK----AIPGLDYMVTERGGNFSVGQRQLLCLARAILRNNKV 1289
            |||||.:..:|.|:|.||.|||||.    .|.||:..:.:.|.|||||||||:||||||||:||:
  Fly  1190 YNLDPMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKI 1254

  Fly  1290 LVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLL 1354
            |::|||||||||:||.|||:|||.||..|||||:||||||||||||::|||||...|...||.||
  Fly  1255 LIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELL 1319

  Fly  1355 KKSQGHLRQMVEATG-GESEALKKTASDSHKR 1385
            :::.|:|||:|:.|| ..|.||::.|..|:.:
  Fly  1320 QRTGGYLRQLVDNTGAATSFALQQAAEQSYSK 1351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	541/1428 (38%)
rdog	NP_651678.1	MRP_assoc_pro	14..1323	CDD:188098	541/1430 (38%)