DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and abcc2

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_956883.2	Gene:	abcc2 / 393561	ZFINID:	ZDB-GENE-040426-1523	Length:	1567	Species:	Danio rerio

Alignment Length:	1464	Identity:	477/1464 - (32%)
Similarity:	759/1464 - (51%)	Gaps:	211/1464 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KPTRKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELER 70
            |....||...|..:|::.|.|...::::|.:|.|..:|:....|.|.:..:....||...|||::
Zfish   202 KVAETNPEAKATFLSRITFNWFNSMVWKGFKRPLVQEDMWDLNKNDSTHFICQTFEDVMAKELKK 266

  Fly    71 SHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVND 135
            :         ||.|                                    ||....:.:.:|
Zfish   267 A---------RNNL------------------------------------QKKKSKKRKTVD--- 283

  Fly   136 ISISDSLNRTARAIPNYVL---------SQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVD 191
               ::..|..|:.:...||         |:..........|:.:|:|.
Zfish   284 ---AEGQNGLAKGVSQDVLVMETETEKESKKKKKKKQKDSDSDYPQSW----------------- 328

  Fly   192 HNATAVRS----ILDQTVEHMWNDMNS-------------------------LGAVLVLSTLFC- 226
            ...|.|:|    :|:..:..:..|:.|                         |.|||::...|.
Zfish   329 LVTTIVKSFKGVLLESALFKLLQDLLSFASPQLLKLMIAFTQNKDSYAWTGYLYAVLLVLVAFVQ 393

  Fly   227 ----------CFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVN 281
                      ||:|          |.::|.|..:.:|:|.|.:|..:..::.||.::||:|.|..
Zfish   394 SVVLQQYFQRCFIL----------GMKVRTAIMAAVYKKALVVSNDSRKESTAGEIVNLMSADAQ 448

  Fly   282 RLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAE 346
            |.:....|:|.:|..|||..|:...:|:.:| |:::..:.:::..||:...|:..:...:|:..:
Zfish   449 RFNDVTNFIHLLWSCPLQIALSIAFLWIELG-PSVLSGLLVMVLMVPINGWLATKSRQFQMQNMK 512

  Fly   347 RTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRGFYLSTMVFTERSTL 411
            ..|:|:.|:|:|:.||:::|.||||..|:|.|.|.|..|:|.:|..:||..  :||.:|:....|
Zfish   513 FKDSRMKIVNDLLNGIKILKYYAWETSFEAQVQEIREKELKVMRKFAYLSS--VSTFIFSCAPAL 575

  Fly   412 YITLAAAALM-----GQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFLML 471
             ::||..|:.     ...:.|:..|::.|.:|||:...|: .|..:|...:..||.:|::.|  |
Zfish   576 -VSLATFAVFVSVSPDNILDAEKAFTSISLFNILRFPLAM-LPQLISIMVQTSVSKKRLEKF--L 636

  Fly   472 EGREERTQGLTHKRDQEGGDSRAVTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGK 536
            .|.:..|..:||    :...:.||::.:...:|: ...:..|:.::|.|:.|:|.||:|.||:||
Zfish   637 SGDDLDTTTVTH----DSSITAAVSMTNGTYAWE-RDTEPVLKRVSLDIKPGRLVAVVGAVGSGK 696

  Fly   537 SSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTD 601
            :|::..|||||..|.|.:.|.|.::|..|:.|:...::::|||||...|.:|||.|.:.|||..|
Zfish   697 TSLVSALLGELHSIKGNININGSVAYVPQQAWIQNATLKDNILFGSSVDEERYQSVIKACALGPD 761

  Fly   602 FQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPR 666
            ...||..|:|.:||:|.:|||||:.|:|||||||..|.:||:||||||||:|||:|||::||||.
Zfish   762 LDLLPGRDQTEIGEKGINLSGGQKQRVSLARAVYSSADVYLLDDPLSAVDSHVGKHLFEKVIGPN 826

  Fly   667 GRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLER-PKEEEEGE 730
            |.|..  .||||:||.:.||...|.||::..|.:...|:|:.|..|...|:..||. .|:|...:
Zfish   827 GLLRD--KTRILITHGISFLPYVDEIVVLVHGVVSEIGSYESLRASKGAFSEFLETYGKDESNKD 889

  Fly   731 NSRNQTSPLSVNSLESDDEDIPFIDGVK---DGYQQ------LRKQSSSVHG---SKSLDSTQLD 783
            |.:...:  :...:..:.|.:|  :|::   ||..:      |::::|..|.   ||...|.::.
Zfish   890 NDKKAAA--AQTPVYEEIETLP--EGLETQADGSPEDIVSSTLKRENSLRHSQRHSKRNGSVKVR 950

  Fly   784 DN------VDEDDL-------AEAQASGGISPRVWYEYFHA-GSTLLSFSFMVFVMVMSQVVCSS 834
            .|      .|.:|.       .|...:|.:...|:.:|..| |...:.||| ||..:.:..|...
Zfish   951 KNSSLRAQKDPEDKKGQRLIEKEMMETGRVKFSVYLQYLSAMGWWYVGFSF-VFYFIQNVAVIGQ 1014

  Fly   835 SDFFANIWTQQEHQRSQGEATFSTFECMY----------IYGALIIAVVIMTTFRGFLFFKICMH 889
            :.:.:: ||         :.:...|...|          ::|||.:|...:..|...|.....:.
Zfish  1015 NLWLSD-WT---------DDSIEYFNQTYPNHIRDTRIGVFGALGLAQGFLVFFGTILLADGSIS 1069

  Fly   890 ASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVI 954
            ||:.||..:...||...|.||||||||||:|||:||:..:||::|.:...:|...|.:.|.|.||
Zfish  1070 ASRTLHTSLLTNILKVPMMFFDTTPSGRIVNRFAKDIFTVDEMIPMSFRSWILCLLGVLGTLFVI 1134

  Fly   955 GILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDV 1019
            .:..|:..|.::.:|||...:.:.|:..|:.|:||:.:.|||::||...:::||::||:...||.
Zfish  1135 CLATPIFTAVVVPMAVVYYFVQRFYVATSRQLRRLDSVSRSPIYSHFGETVSGLSVIRAYGHQDR 1199

  Fly  1020 VAK--EFDLLQDVHSSV-WQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIA 1081
            ..|  |..:.|::.|.. |   :..|..|.:.|:.:..:.:.......:||.::..||.|||:|:
Zfish  1200 FLKRNEHTIDQNLKSVYPW---IVSNRWLAMRLESLGNLVVFFAALFAVISRDSLNSGLVGLSIS 1261

  Fly  1082 QAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQE-PALGEKTPPQQWPTRGQVEFRNMSCR 1145
            .|:.:|..:.:.||..:|....:.:||||.:|.|::.| |.:....||..||:.|.:.|.:...|
Zfish  1262 YALNVTQTLNWLVRMTSELETNIVAVERVREYAEIQNEAPWVTSVRPPDDWPSAGNIRFEDYKVR 1326

  Fly  1146 YDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-IEGEIFIDGIETGTISLEIL 1209
            |.|....||..:...|::..|:|||||||||||||...|||:.. .:|.|.||.|:..|:.|..|
Zfish  1327 YRPELELVLHGVTCDIQSTEKIGIVGRTGAGKSSLTNCLFRIVEAADGRILIDDIDIATLGLHDL 1391

  Fly  1210 RTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELR---KAIP-GLDYMVTERGGNFS 1270
            |:|::||||||||||.|:|.|||||:.::|||:||.||...|:   :.:| ||::.|:|.|.|.|
Zfish  1392 RSRLTIIPQDPVLFSGTLRMNLDPFQTFSDAEIWSVLELAHLKEYVRGLPTGLEHEVSEGGENLS 1456

  Fly  1271 VGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDR 1335
            :|||||||||||:||.:::|:||||||.||.:||.|||.|||.:|..|||||:||||:|::||.|
Zfish  1457 LGQRQLLCLARALLRKSRILILDEATAAVDLETDDLIQSTIRREFSHCTVLTIAHRLNTILDSSR 1521

  Fly  1336 IIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEATG 1369
            ::|:|:|..||||.|..||.| .||...|.|..|
Zfish  1522 VMVLDSGKIVEFDSPNELLSK-PGHFSSMAEDAG 1554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	474/1457 (33%)
		ABC_membrane	214..441	CDD:294371	71/267 (27%)
		ABCC_MRP_domain1	495..699	CDD:213217	95/203 (47%)
		ABC_membrane	863..1088	CDD:294371	76/237 (32%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	119/219 (54%)
abcc2	NP_956883.2	MRP_assoc_pro	10..1555	CDD:188098	477/1464 (33%)
		ABC_membrane	346..612	CDD:294371	73/279 (26%)
		ABCC_MRP_domain1	656..856	CDD:213217	95/202 (47%)
		ABC_membrane	1001..1270	CDD:279056	84/282 (30%)
		ABCC_MRP_domain2	1316..1536	CDD:213211	119/219 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.730