Protein Alignment Cftr and abcc2

DIOPT Version :10

• Sequence 1: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_956883.2
• Gene: abcc2 / 393561
• ZFINID: ZDB-GENE-040426-1523
• Length: 1567
• Species: Danio rerio
• Alignment Length: 1464
• Identity: 477/1464 - (32%)
• Similarity: 759/1464 - (51%)
• Gaps: 211/1464 - (14%)

  Fly     6 KPTRKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELER 70
            |....||...|..:|::.|.|...::::|.:|.|..:|:....|.|.:..:....||...|||::
Zfish   202 KVAETNPEAKATFLSRITFNWFNSMVWKGFKRPLVQEDMWDLNKNDSTHFICQTFEDVMAKELKK 266

  Fly    71 SHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVND 135
            :         ||.|                                    ||....:.:.:|
Zfish   267 A---------RNNL------------------------------------QKKKSKKRKTVD--- 283

  Fly   136 ISISDSLNRTARAIPNYVL---------SQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVD 191
               ::..|..|:.:...||         |:..........|:.:|:|.
Zfish   284 ---AEGQNGLAKGVSQDVLVMETETEKESKKKKKKKQKDSDSDYPQSW----------------- 328

  Fly   192 HNATAVRS----ILDQTVEHMWNDMNS-------------------------LGAVLVLSTLFC- 226
            ...|.|:|    :|:..:..:..|:.|                         |.|||::...|.
Zfish   329 LVTTIVKSFKGVLLESALFKLLQDLLSFASPQLLKLMIAFTQNKDSYAWTGYLYAVLLVLVAFVQ 393

  Fly   227 ----------CFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVN 281
                      ||:|          |.::|.|..:.:|:|.|.:|..:..::.||.::||:|.|..
Zfish   394 SVVLQQYFQRCFIL----------GMKVRTAIMAAVYKKALVVSNDSRKESTAGEIVNLMSADAQ 448

  Fly   282 RLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAE 346
            |.:....|:|.:|..|||..|:...:|:.:| |:::..:.:::..||:...|:..:...:|:..:
Zfish   449 RFNDVTNFIHLLWSCPLQIALSIAFLWIELG-PSVLSGLLVMVLMVPINGWLATKSRQFQMQNMK 512

  Fly   347 RTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRGFYLSTMVFTERSTL 411
            ..|:|:.|:|:|:.||:::|.||||..|:|.|.|.|..|:|.:|..:||..  :||.:|:....|
Zfish   513 FKDSRMKIVNDLLNGIKILKYYAWETSFEAQVQEIREKELKVMRKFAYLSS--VSTFIFSCAPAL 575

  Fly   412 YITLAAAALM-----GQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVSLRRIQDFLML 471
             ::||..|:.     ...:.|:..|::.|.:|||:...|: .|..:|...:..||.:|::.|  |
Zfish   576 -VSLATFAVFVSVSPDNILDAEKAFTSISLFNILRFPLAM-LPQLISIMVQTSVSKKRLEKF--L 636

  Fly   472 EGREERTQGLTHKRDQEGGDSRAVTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGK 536
            .|.:..|..:||    :...:.||::.:...:|: ...:..|:.::|.|:.|:|.||:|.||:||
Zfish   637 SGDDLDTTTVTH----DSSITAAVSMTNGTYAWE-RDTEPVLKRVSLDIKPGRLVAVVGAVGSGK 696

  Fly   537 SSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTD 601
            :|::..|||||..|.|.:.|.|.::|..|:.|:...::::|||||...|.:|||.|.:.|||..|
Zfish   697 TSLVSALLGELHSIKGNININGSVAYVPQQAWIQNATLKDNILFGSSVDEERYQSVIKACALGPD 761

  Fly   602 FQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPR 666
            ...||..|:|.:||:|.:|||||:.|:|||||||..|.:||:||||||||:|||:|||::||||.
Zfish   762 LDLLPGRDQTEIGEKGINLSGGQKQRVSLARAVYSSADVYLLDDPLSAVDSHVGKHLFEKVIGPN 826

  Fly   667 GRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLER-PKEEEEGE 730
            |.|..  .||||:||.:.||...|.||::..|.:...|:|:.|..|...|:..||. .|:|...:
Zfish   827 GLLRD--KTRILITHGISFLPYVDEIVVLVHGVVSEIGSYESLRASKGAFSEFLETYGKDESNKD 889

  Fly   731 NSRNQTSPLSVNSLESDDEDIPFIDGVK---DGYQQ------LRKQSSSVHG---SKSLDSTQLD 783
            |.:...:  :...:..:.|.:|  :|::   ||..:      |::::|..|.   ||...|.::.
Zfish   890 NDKKAAA--AQTPVYEEIETLP--EGLETQADGSPEDIVSSTLKRENSLRHSQRHSKRNGSVKVR 950

  Fly   784 DN------VDEDDL-------AEAQASGGISPRVWYEYFHA-GSTLLSFSFMVFVMVMSQVVCSS 834
            .|      .|.:|.       .|...:|.:...|:.:|..| |...:.||| ||..:.:..|...
Zfish   951 KNSSLRAQKDPEDKKGQRLIEKEMMETGRVKFSVYLQYLSAMGWWYVGFSF-VFYFIQNVAVIGQ 1014

  Fly   835 SDFFANIWTQQEHQRSQGEATFSTFECMY----------IYGALIIAVVIMTTFRGFLFFKICMH 889
            :.:.:: ||         :.:...|...|          ::|||.:|...:..|...|.....:.
Zfish  1015 NLWLSD-WT---------DDSIEYFNQTYPNHIRDTRIGVFGALGLAQGFLVFFGTILLADGSIS 1069

  Fly   890 ASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVI 954
            ||:.||..:...||...|.||||||||||:|||:||:..:||::|.:...:|...|.:.|.|.||
Zfish  1070 ASRTLHTSLLTNILKVPMMFFDTTPSGRIVNRFAKDIFTVDEMIPMSFRSWILCLLGVLGTLFVI 1134

  Fly   955 GILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDV 1019
            .:..|:..|.::.:|||...:.:.|:..|:.|:||:.:.|||::||...:::||::||:...||.
Zfish  1135 CLATPIFTAVVVPMAVVYYFVQRFYVATSRQLRRLDSVSRSPIYSHFGETVSGLSVIRAYGHQDR 1199

  Fly  1020 VAK--EFDLLQDVHSSV-WQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIA 1081
            ..|  |..:.|::.|.. |   :..|..|.:.|:.:..:.:.......:||.::..||.|||:|:
Zfish  1200 FLKRNEHTIDQNLKSVYPW---IVSNRWLAMRLESLGNLVVFFAALFAVISRDSLNSGLVGLSIS 1261

  Fly  1082 QAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQE-PALGEKTPPQQWPTRGQVEFRNMSCR 1145
            .|:.:|..:.:.||..:|....:.:||||.:|.|::.| |.:....||..||:.|.:.|.:...|
Zfish  1262 YALNVTQTLNWLVRMTSELETNIVAVERVREYAEIQNEAPWVTSVRPPDDWPSAGNIRFEDYKVR 1326

  Fly  1146 YDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAH-IEGEIFIDGIETGTISLEIL 1209
            |.|....||..:...|::..|:|||||||||||||...|||:.. .:|.|.||.|:..|:.|..|
Zfish  1327 YRPELELVLHGVTCDIQSTEKIGIVGRTGAGKSSLTNCLFRIVEAADGRILIDDIDIATLGLHDL 1391

  Fly  1210 RTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELR---KAIP-GLDYMVTERGGNFS 1270
            |:|::||||||||||.|:|.|||||:.::|||:||.||...|:   :.:| ||::.|:|.|.|.|
Zfish  1392 RSRLTIIPQDPVLFSGTLRMNLDPFQTFSDAEIWSVLELAHLKEYVRGLPTGLEHEVSEGGENLS 1456

  Fly  1271 VGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDR 1335
            :|||||||||||:||.:::|:||||||.||.:||.|||.|||.:|..|||||:||||:|::||.|
Zfish  1457 LGQRQLLCLARALLRKSRILILDEATAAVDLETDDLIQSTIRREFSHCTVLTIAHRLNTILDSSR 1521

  Fly  1336 IIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEATG 1369
            ::|:|:|..||||.|..||.| .||...|.|..|
Zfish  1522 VMVLDSGKIVEFDSPNELLSK-PGHFSSMAEDAG 1554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	469/1443 (33%)
abcc2	NP_956883.2	MRP_assoc_pro	10..1555	CDD:188098	477/1464 (33%)