Protein Alignment CG5789 and CG10226

DIOPT Version :9

• Sequence 1: NP_001247286.1
• Gene: CG5789 / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_648040.1
• Gene: CG10226 / 38725
• FlyBaseID: FBgn0035695
• Length: 1320
• Species: Drosophila melanogaster
• Alignment Length: 1437
• Identity: 308/1437 - (21%)
• Similarity: 594/1437 - (41%)
• Gaps: 290/1437 - (20%)

  Fly    69 ERSHRKKQKPHLR-NALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNID 132
            ::..::|.:|.:. ..|||...|         :.|:|:.:...|...|.|:    .|:|    |.
  Fly    25 KKKTKEKAQPMVSYTELFRYIAG---------WDYLVLLSGFVAAFLQSLV----FPIA----IV 72

  Fly   133 VNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALF--PKSLDKAGPLEPIQPPVEEVDHNAT 195
            |....::..:.||        |.|  ..||.:.|.:||  .|.|..|.
  Fly    73 VYSELVAMFIERT--------LGQ--GTSSVTIGLSLFGGGKILTNAS----------------- 110

  Fly   196 AVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFL-LHHVDLRQRL---MGARMRIACCSLIYRKT 256
                 .::.::.:..|..|.|.::.|:||...|. :::||...||   :..|||    ...::.|
  Fly   111 -----YEENMQELRKDSVSFGILMTLNTLLMLFSGVYYVDAFNRLALKLTVRMR----REFFKAT 166

  Fly   257 LRLSMKTAGQTPAGYLINLLSNDVNRLDYGFI--FMHWIWIMPLQAMLTCYLIWLNIGIPAIVG- 318
            ||..:..............:::::.::..|..  ..|::.||       |.:| :::.:..|.|
  Fly   167 LRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAENLGHYVEIM-------CDVI-ISVVLSFIYGW 223

  Fly   319 -----VVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVV 378
                 :|..:..|:.|.:|::.....|..:..........::.|::..|:.:..:..|
  Fly   224 KLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIGAIRTVVAFGGE------- 281

  Fly   379 AEARRSEIKQIRYASYL---------RGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAA 434
                |||  .:||.|.|         :|.:........::.|:||.|.:...|..:..
  Fly   282 ----RSE--SLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGANLIL------- 333

  Fly   435 SYYN---------------ILQLVAAIWYPLAVSFGAEALVSLRRI-------QDFLMLEGRE-- 475
             ||.               ::.:::.|            :||..:|       :.|.|..|..
  Fly   334 -YYRDPSIPIDEREYTPAVVMIVISGI------------IVSANQISRTSPFLETFAMARGSASA 385

  Fly   476 -----ERTQGLTHKRDQEG-----GDSRAVTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIG 530
                 :|| .|.....:.|     |...||..:|:...:...:....|:.:|:.:|:||..|::|
  Fly   386 ILDVIDRT-SLIDPLSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVG 449

  Fly   531 PVGAGKSSILQLLLGELPVIDGGVFIQGD-------------LSYAAQEPWLFTGSVRNNILFGE 582
            |.|.|||:.:|||......:.|.|.:.|:             ::...|||.||.||:..||..|:
  Fly   450 PSGCGKSTCIQLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGK 514

  Fly   583 -EFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDP 646
             |..:|..::..:..........|..|..|.:.|:|..||||||.||::|||:.:..:|.|:|:.
  Fly   515 PEATQKEVEDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEA 579

  Fly   647 LSAVDAH---VGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQE 708
            .||:|.|   :.:...|:..  :||      |.::|:|::..:..|..||.::.|:.:.|||::|
  Fly   580 TSALDYHSEKLVQAALDKAC--KGR------TTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEE 636

  Fly   709 LINSDLDFARLLERPKEEEEGENSRNQTSPLS-VNSLESDDEDIPFIDGVKDGYQQLRK----QS 768
            |:..:..:.:::.....::..|...|:...:: :...:...|..|:..|.::....|.|    |.
  Fly   637 LMKLEGFYHKMVTVHSYDDSAEELLNELEEVAEIKERKMSYEVEPYQLGTRNSIVSLEKNAEFQM 701

  Fly   769 SSVHGSKSLDSTQLDDNVDEDDLAEA-------QASGGISPRVWYEYFHAGST---LLSFSFMVF 823
            .:::|   |.:..::..:|:..:..|       :..|...|.  :.:...|:.   |...:..||
  Fly   702 KNLNG---LANITMNQEIDDPRVPSANFISTFFRILGWARPE--WSFLIIGAICAGLYGVTMPVF 761

  Fly   824 VMVMSQVVCSSSDFFANIWTQQEHQRSQGEATFSTFECMYIYGALIIAVVIMTTFRGFLFFKIC- 887
            .:|::::..|    .|....::..::|...|..|     .:.|.....|..:.||    ||.:.
  Fly   762 SVVLAELYGS----LAKPTDEEVLEQSASMAIIS-----LVIGIAAGVVCYIQTF----FFNLAG 813

  Fly   888 MHASKVLHDRMFACILHATMRFFDTTPS--GRILNRFSKDMGAIDELLPRAMMDFIQ-------- 942
            :..:..:..:.|.||::..|.:||...:  |.:..|.|.|..::...:...:.:.||
  Fly   814 VWLTTRMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICS 878

  Fly   943 IALVM---FGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSAS 1004
            ||:..   :.:.::....:|.:||:::..|....   |..|:..:.|:....|.        :.:
  Fly   879 IAIAFPYSWELALICLSTSPFMVASIVFEARFGE---KSALKEKEVLEETSRIA--------TET 932

  Fly  1005 LTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSE 1069
            :|.:..:...:.::.:.|.:|  ::|.....|:...:.     |...|:.:..:.:.|.:.::
  Fly   933 ITQIRTVAGLRREEELIKIYD--KEVERYRHQILSRLK-----WRGLVNSLGKSLMFFGYAVT-- 988

  Fly  1070 TTYSGNV----GLAIAQAMILTGMVQYGVRQVAESL-------QQMTSVERVLQYTELEQEPAL- 1122
            .||.|::    .:.....|.::..:.||:..:|:||       ..:.|..|:  |..::::|.:
  Fly   989 LTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAALLSANRM--YEIIDRKPQIQ 1051

  Fly  1123 ----------GEKTPPQQWPTRGQVEFRNMSCRYDPNGS-PVLRNLNLTIEAGWKVGIVGRTGAG 1176
                      |..|..:....:..|.:|.::..|..... .||:|.||.|..|..|.:||.:|:|
  Fly  1052 SPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNFNLDINQGQTVALVGASGSG 1116

  Fly  1177 KSSLIGALFRLAH-IEGEIFIDGIET-GTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTD 1239
            ||:.:..|.|... .||:|.||.... ..:.|:.||.|:.|:.|:|.||..:|..|:...:....
  Fly  1117 KSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIADNIGYGDTSRQ 1181

  Fly  1240 AELWSALEDVELRKA------IPG-LDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATA 1297
            ..:...:|..::..|      :|. .|.::..:|...|.||:|.:.:|||::||.|:|:|||||:
  Fly  1182 VPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLLDEATS 1246

  Fly  1298 NVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLR 1362
            .:|.|::.::|:.:.......|.:.:||||.|:.:::.|.|:.||..||           ||...
  Fly  1247 ALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKIVE-----------QGSHS 1300

  Fly  1363 QMVEATG 1369
            |::...|
  Fly  1301 QLLAKNG 1307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	307/1433 (21%)
		ABC_membrane	214..441	CDD:294371	47/262 (18%)
		ABCC_MRP_domain1	495..699	CDD:213217	64/220 (29%)
		ABC_membrane	863..1088	CDD:294371	40/242 (17%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	71/224 (32%)
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	293/1364 (21%)
		ABC_membrane	<147..333	CDD:279056	37/210 (18%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	70/242 (29%)
		ABC_membrane	749..1019	CDD:279056	51/302 (17%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	75/243 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910