Protein Alignment CG5789 and CG10505

DIOPT Version :9

• Sequence 1: NP_001247286.1
• Gene: CG5789 / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Sequence 2: NP_611571.2
• Gene: CG10505 / 37428
• FlyBaseID: FBgn0034612
• Length: 1312
• Species: Drosophila melanogaster
• Alignment Length: 1457
• Identity: 530/1457 - (36%)
• Similarity: 797/1457 - (54%)
• Gaps: 215/1457 - (14%)

  Fly     1 MDSS--AKPTRK-NPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLED 62
            ||:|  :.|.|: ||...|||||:.:|.|...:..:|.|..|:...|.:.|....||.|...|:.
  Fly     1 MDASKQSSPKRESNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQP 65

  Fly    63 QWFKELERSHRKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLI----PAVLAQLLIQFQKT 123
            .|.||     .||:.|.|...:|:.: |...:.  :|.:|.:::..|    |.:|..|:..|.
  Fly    66 HWEKE-----SKKKNPSLMRLIFKVY-GWQFVP--VCILYSLLEMAIHSFQPLLLGGLISYFA-- 120

  Fly   124 PVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVE 188
                                                                             
  Fly   121 ----------------------------------------------------------------- 120

  Fly   189 EVDHNATAVRSILDQTVEHMWNDMNSLGAV---LVLSTLFCCFLLHHVDLRQRLMGARMRIACCS 250
               :..|.|      |.|..:  :.::|.|   ||.|.:|..|:.:..     .:|.|:|:||..
  Fly   121 ---YGQTTV------TKESAY--LYAMGIVLCSLVTSLVFHPFMFYVF-----AVGTRVRLACAG 169

  Fly   251 LIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPA 315
            |:|||.||.| .::|:...|..|:::|.|:::.|..|.|.|.:|..|::|.:..||:...:|..:
  Fly   170 LVYRKCLRAS-ASSGEGLGGQAISVMSIDLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTS 233

  Fly   316 IVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAE 380
            ::|:..::: .:|:|...:|.::....|.|:..||||.:|||::..|||||||||||.|..::|.
  Fly   234 LIGIAFIVI-LIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAA 297

  Fly   381 ARRSEIKQIR-----YASYLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNIL 440
            .|:||:|.||     ||:      |.......:.:|:::|.|...:|..:||..||..:|||.:|
  Fly   298 VRQSEVKAIRGSMSIYAA------LQCTNMISKISLFLSLVAYVYVGDLVTAKKVFILSSYYGLL 356

  Fly   441 QLVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEG---------------- 489
            ......::|:|::..|:.|||.||:.:||:   :.|:....:..||..|
  Fly   357 NDSLLHYWPMAITTWAQTLVSARRVVEFLL---QVEKPTEESCCRDNPGLELDAEKPKPAQSGRL 418

  Fly   490 ----GDSRAVTIKDINASWD---IEKPQKT-LQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGE 546
                .:::.::.:.::||||   |::|:|. ::.|:..|..||...::|.||:|||::|..:|||
  Fly   419 HCVQSETKCLSFRKVSASWDKPSIKQPRKPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGE 483

  Fly   547 LPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKT 611
            :.::.|.|.:.|.:|||||:||:|.||:|.||||.|:::.|||:.|...|.|..|.:.||.||.|
  Fly   484 IELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDAT 548

  Fly   612 LVGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATR 676
            :|||||.||||||:|||:||||||:.|.|||.||||:||||.||:.|.|:..   .||...| .|
  Fly   549 VVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCF---HRLLDGK-MR 609

  Fly   677 ILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLERPKEEEEGENSRNQTSPLSV 741
            |||||.|..|...|.:::::.|::.:||:|:||                    ::.....:.|.:
  Fly   610 ILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEEL--------------------KDVITHHAALDL 654

  Fly   742 NSLESDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISPRVWY 806
            .::|:|.:.      ||....|:.:.|..:...:..|...:.   ||:..||.|..|.:|...:.
  Fly   655 EAIEADKQQ------VKRVLSQVDRTSKQLSKGEEKDPATIQ---DENGNAEQQLQGAVSYDTYK 710

  Fly   807 EYFHAGSTLLSFSFMVFVMVMSQVV----CSS-SDFFANIWTQQEHQRSQGEATFSTFEC----M 862
            .||.|    |...|:| .:|:|..|    |.: .|.|.:.|...|..|  |..:...:|.    |
  Fly   711 AYFRA----LGAPFLV-CLVLSMFVLARGCQAVMDIFISRWATWEEDR--GYDSVDDYEATRTKM 768

  Fly   863 YI-YGALIIAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDM 926
            .| |..|::..:.:...|.|.||.:|:..|..|||:::..|:.|.|.||:..||||:|||||.|:
  Fly   769 VIWYTVLLLLTLALFLLRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDI 833

  Fly   927 GAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLIL----KLYLRPSQDLK 987
            ..:|..||:||||.:|..:.:..:|:::.|.|..|    |:.|.:.|::|    .||:..|:.||
  Fly   834 QNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWL----LIPAAIMVILLYFCRALYIGASRSLK 894

  Fly   988 RLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCV 1052
            |:|.:.|||::||.:.:..|.:.|||......:.:.|...|:.:||...|.::.|.....|.|.:
  Fly   895 RIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANRAFSFWTDLI 959

  Fly  1053 SCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELE 1117
            ..|::.:|||||::.:::.|||:|||||.|:|.|..|.|:|:||.||....||||||||:|.:..
  Fly   960 CVIYILAVTFSFLVINQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTP 1024

  Fly  1118 QEPALGEKTPPQ-----QWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGK 1177
            .||.|  ::|..     :||..|.:.|:::..||.|....:||.||...:...|:||||||||||
  Fly  1025 SEPPL--ESPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGK 1087

  Fly  1178 SSLIGALFRLAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAEL 1242
            ||:|.||||||..||.|.|||::.|.:.|..||:|||||||||||||.|:|:|||||:..:|..|
  Fly  1088 SSIIQALFRLALNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESL 1152

  Fly  1243 WSALEDVELRKAIP----GLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQT 1303
            ||||:||:|:|.:.    ||...:.:.|.|||:|||||:||||||||.|:|||:||||||||.:|
  Fly  1153 WSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTET 1217

  Fly  1304 DALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHLRQMVEAT 1368
            |.|||.||:.||.:|||||:|||||||||:|.::|||||..|||..|:.||::..|.|.::|...
  Fly  1218 DILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLVNQN 1282

  Fly  1369 GGES-EALKKTASDSHKRMQRERDERD 1394
            ...: :.||:.||:|:.|    |:.||
  Fly  1283 DATTVKFLKRIASESYMR----RNRRD 1305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	517/1417 (36%)
		ABC_membrane	214..441	CDD:294371	80/234 (34%)
		ABCC_MRP_domain1	495..699	CDD:213217	100/207 (48%)
		ABC_membrane	863..1088	CDD:294371	84/229 (37%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	132/218 (61%)
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	511/1403 (36%)
		ABC_membrane	95..360	CDD:294371	91/355 (26%)
		ABCC_MRP_domain1	428..632	CDD:213217	100/207 (48%)
		ABC_membrane	728..994	CDD:294371	93/271 (34%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	132/218 (61%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	142	1.000	Domainoid score	I2904
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm14754
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.870