DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and ABCC6

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	XP_024306029.1	Gene:	ABCC6 / 368	HGNCID:	57	Length:	1515	Species:	Homo sapiens

Alignment Length:	1446	Identity:	447/1446 - (30%)
Similarity:	690/1446 - (47%)	Gaps:	224/1446 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PTRKN--PRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWF--KE 67
            |.:.|  |...|...|:..|.|...|::||.||.|...||....:|:.||:|..|||.:|.  :.
Human   209 PQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRS 273

  Fly    68 LERSHRK----KQK-----------PHLR----------NALFRCFLGPTIINGLICFIYIVIKT 107
            ..|.|.|    |:|           |.||          .|:::.|....::..|...|..|.:.
Human   274 AARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRF 338

  Fly   108 LIPAVLAQLLIQFQKTPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPK 172
            .:|.:|: |.::|                 |.|                              ||
Human   339 TVPKLLS-LFLEF-----------------IGD------------------------------PK 355

  Fly   173 SLDKAGPLEPIQPPVEEVDHNATAVRSILDQTVEHMWNDMNSLGAVL-VLSTLFCCF--LLHHVD 234
                        ||.                     |.     |.:| ||..|..|.  |....:
Human   356 ------------PPA---------------------WK-----GYLLAVLMFLSACLQTLFEQQN 382

  Fly   235 L-RQRLMGARMRIACCSLIYRKTLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPL 298
            : |.:::..|:|.|...|:|||.|.||..:...:..|.::||:|.||.||....::::.:| :||
Human   383 MYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLW-LPL 446

  Fly   299 QAMLTCYL-IWLNIGIPAIVGVVGLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGI 362
            ..::.|:: :|..:| |:.:..:.:.|..:|:...:||..:..:.....:.|:|..:.:.:::..
Human   447 VWIVVCFVYLWQLLG-PSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNS 510

  Fly   363 QVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALMGQTITA 427
            :.||.:.||..|...|...|..|:..:|.:..|  |.:|.:.| :.||..:.|...|:  .|:.|
Human   511 KTIKFHGWEGAFLDRVLGIRGQELGALRTSGLL--FSVSLVSF-QVSTFLVALVVFAV--HTLVA 570

  Fly   428 DFVFSAASYY------NILQLVAAIWYPLAVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRD 486
            :...:|...:      |||....| :.|.::....:|.||..|:..||.|   ||...|:.   |
Human   571 ENAMNAEKAFVTLTVLNILNKAQA-FLPFSIHSLVQARVSFDRLVTFLCL---EEVDPGVV---D 628

  Fly   487 QEGGDSRA----VTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGEL 547
            .....|.|    :||.....:|..|.| ..|..|||.:.:|.|.||:|||||||||:|..|||||
Human   629 SSSSGSAAGKDCITIHSATFAWSQESP-PCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGEL 692

  Fly   548 PVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTL 612
            ..::|.|.|:|.::|..||.|:...||..|:.||:|.|....:.|...|||..|....|.|..|.
Human   693 SKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTS 757

  Fly   613 VGERGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRI 677
            :||:|.:|||||:.|:|||||||:.|.:||:||||:|:|||||:|:|::||||.|.|.  ..|||
Human   758 IGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQ--GTTRI 820

  Fly   678 LVTHQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLERPKEEEEGENSRNQTSPLSVN 742
            ||||.:|.|.:||.|:::..|.|...|:||||:........||::.:  :.|:....:|.|   .
Human   821 LVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALMCLLDQAR--QPGDRGEGETEP---G 880

  Fly   743 SLESDDEDIPFIDGVKDGYQ-QLRKQSS--SV-HGSKSLDSTQLDDNVDEDDLAEAQAS------ 797
            :...|..      |...|.: :||::.|  || ...::....|.:..:|:.|.|...|.
Human   881 TSTKDPR------GTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQY 939

  Fly   798 GGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQ------QEHQRSQGEATF 856
            |.:...|...|..|..|.|.. :.:|:.:..||......::.::|..      |:.|.:.....|
Human   940 GRVKATVHLAYLRAVGTPLCL-YALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIF 1003

  Fly   857 STFECMYIYGALI-IAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILN 920
            ....|:...|... :|.|::...|          ||::|..|:...::.:.:.||:.||.|.:||
Human  1004 GLLGCLQAIGLFASMAAVLLGGAR----------ASRLLFQRLLWDVVRSPISFFERTPIGHLLN 1058

  Fly   921 RFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQD 985
            ||||:...:|..:|..:...:..|..:..:.:|:.:..|:...|:|.:.::......||:..|..
Human  1059 RFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQ 1123

  Fly   986 LKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSV---------WQLTMAV 1041
            |:|||....|.|.||::.:..|..::|:.:.|.....:.:...|....:         |   :|.
Human  1124 LRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRW---LAA 1185

  Fly  1042 NTTL---GLWLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQ 1103
            |..|   ||.....:|..|:....|         :|.||.:::.|:.:|..:|:.||...:....
Human  1186 NVELLGNGLVFAAATCAVLSKAHLS---------AGLVGFSVSAALQVTQTLQWVVRNWTDLENS 1241

  Fly  1104 MTSVERVLQYTELEQE-----PALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEA 1163
            :.||||:..|....:|     |....:.|   ||..||:|||:...||.|.....::.::..|.|
Human  1242 IVSVERMQDYAWTPKEAPWRLPTCAAQPP---WPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHA 1303

  Fly  1164 GWKVGIVGRTGAGKSSLIGALFRLAH-IEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATI 1227
            |.|||||||||||||||...|.||.. .||.|:|||:....:.|..||:|||||||||:||..::
Human  1304 GEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSL 1368

  Fly  1228 RYNLDPFERYTDAELWSALEDVELR---KAIPG-LDYMVTERGGNFSVGQRQLLCLARAILRNNK 1288
            |.|||..:.::|..:|:|||.|:|:   .::|| |.|...:||.:.||||:||||||||:||..:
Human  1369 RMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQ 1433

  Fly  1289 VLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLL 1353
            :|:||||||.|||.|:..:|..:...|.|||||.:||||.:|||..|::|||.|...|...|..|
Human  1434 ILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQL 1498

  Fly  1354 LKKSQGHLRQMVEATG 1369
            |.: :|...::.:.:|
Human  1499 LAQ-KGLFYRLAQESG 1513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	445/1440 (31%)
		ABC_membrane	214..441	CDD:294371	61/237 (26%)
		ABCC_MRP_domain1	495..699	CDD:213217	100/203 (49%)
		ABC_membrane	863..1088	CDD:294371	54/237 (23%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	111/219 (51%)
ABCC6	XP_024306029.1	SunT	14..1514	CDD:331423	447/1446 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720