DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5789 and CG9270

DIOPT Version :9

Sequence 1:NP_001247286.1 Gene:CG5789 / 42928 FlyBaseID:FBgn0039207 Length:1402 Species:Drosophila melanogaster
Sequence 2:NP_995741.2 Gene:CG9270 / 35366 FlyBaseID:FBgn0032908 Length:1292 Species:Drosophila melanogaster


Alignment Length:1406 Identity:582/1406 - (41%)
Similarity:822/1406 - (58%) Gaps:146/1406 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 AKPTRKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELE 69
            ||..:.|||:.|.|.|.|:|.:|:|:|::|.::.|...||...|||.::|.|||:....|..|:.
  Fly     3 AKKLQTNPRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSEVR 67

  Fly    70 R-SHRKKQKPHLRNALFRCFLGPTIINGLIC-FIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNID 132
            . ....|::|.:...:.:.|.....::|::. .:.:..:..:|.:|..|:.:|.:          
  Fly    68 SCGDSPKKEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALIAEFTR---------- 122

  Fly   133 VNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAV 197
                                       |.:|                                  
  Fly   123 ---------------------------NGNG---------------------------------- 126

  Fly   198 RSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMK 262
                    :.:|..:  .|..|:||.||...:.|.:.:....:..:||:|..:.||||.||||..
  Fly   127 --------DGLWAQI--YGLTLILSILFSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRLSRT 181

  Fly   263 TAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTV 327
            ..|.|..|.::||:|||:.|.|...|..|::|:.||:.:::.|.::..||:.::.|:| :||..:
  Fly   182 ALGDTTTGQVVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIV-ILLLFL 245

  Fly   328 PVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYA 392
            |:||.||::||.||.:.|.|||.||.:|||::.||||||||.|||||..::...||||:..||..
  Fly   246 PIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKV 310

  Fly   393 SYLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAE 457
            :|:||..||..:...|..::::|....|||..:||:..||..::||||:.....::|..:|..||
  Fly   311 NYIRGTLLSFEITLSRIAIFVSLLGFVLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAE 375

  Fly   458 ALVSLRRIQDFLMLEGREERTQGLTHKRDQ-----EGGDSRAVTIKDINASWDIEKPQKTLQSIN 517
            .:|:||||:.|:|   |.| |:.|..|..|     ||  ...|.::...|.|:.:..:..|::||
  Fly   376 MMVTLRRIKGFMM---RSE-TEALYLKGGQTNKLFEG--EPLVKLQSFQARWNHDHVEPVLENIN 434

  Fly   518 LQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNILFGE 582
            :.:...||.|||||||:||||::|.:|||||...|.:.:|||:|||:||||||..|||:|||||.
  Fly   435 ISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVRDNILFGL 499

  Fly   583 EFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMDDPL 647
            ..|:.||:.|.|.|||..||:.| :||:|.|||||||||||||||||||||||:.|..||:||||
  Fly   500 PMDKHRYRNVIRNCALERDFELL-HGDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPL 563

  Fly   648 SAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQELINS 712
            ||||.|||||||:|.:  ||.|.....  ||||||:.||..||:|||:|:|:|...|||:|::.|
  Fly   564 SAVDTHVGRHLFEECM--RGFLRDKLV--ILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKS 624

  Fly   713 DLDFARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQQLRKQSSSVH--GSK 775
            ..||.:|| ..:.:|.|::::.|     ||: |.|..:      .|..|.   :|||.|.  ...
  Fly   625 GQDFGKLL-ATEAQEMGDSNQEQ-----VNA-EGDSRN------DKSTYS---RQSSRVSRVSVT 673

  Fly   776 SLDST--QLDDNVDEDDLAEAQASGGISPRVWYEYFHAGSTLLSFSFMVFVMVMSQVVCSSSDFF 838
            |:||:  .:.|| :.....|:::.|.|...::.:||.|||..|....:.|..:.:|::.|..|:|
  Fly   674 SVDSSTESILDN-ERQPAQESRSQGKIGLGIYGKYFSAGSGWLMVILVAFFCLGTQILASGGDYF 737

  Fly   839 ANIWTQQEHQRSQGEATFSTFECMYIYGALIIAVVIMTTFRGFLFFKICMHASKVLHDRMFACIL 903
            .:.|.:.....|..:        :||:..:..|:||....|..|||.:.||:|..||:.||..:.
  Fly   738 LSYWVKNNDSSSSTD--------IYIFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVS 794

  Fly   904 HATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVV 968
            ...:.||...|||||||||:.|:|.:||:||..|:|.|||.|.:.||:.|:.|.||..:...:.:
  Fly   795 RTALYFFHANPSGRILNRFAMDLGQVDEILPAVMLDCIQIFLTISGIIGVLCITNPWYLINTITM 859

  Fly   969 AVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSS 1033
            .:....:...||..|:||||||.|.|||::||.||:|.||:.||:.:.||::.||:|..||:|||
  Fly   860 FLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSS 924

  Fly  1034 VWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVA 1098
            .:...::.|...|.:||.....::.|||.....:......|.:||.|.|||.:||.||:|:||.|
  Fly   925 GYYTFLSTNRAFGYYLDLFCVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSA 989

  Fly  1099 ESLQQMTSVERVLQYTELEQEPALGE------KTPPQQWPTRGQVEFRNMSCRY--DPNGSPVLR 1155
            |....||||||||:|..||.|   ||      |.||..||..|.:....:|.||  ||....||:
  Fly   990 ELENSMTSVERVLEYRHLEAE---GEFESPDDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLK 1051

  Fly  1156 NLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHIEGEIFIDGIETGTISLEILRTRISIIPQDP 1220
            :||..|....|:||||||||||||||.|||||::.||.:.||..:...|.|..||::||||||:|
  Fly  1052 SLNFIIMPREKIGIVGRTGAGKSSLINALFRLSYNEGSLVIDNTDILGIGLHDLRSKISIIPQEP 1116

  Fly  1221 VLFSATIRYNLDPFERYTDAELWSALEDVELRKAIP----GLDYMVTERGGNFSVGQRQLLCLAR 1281
            ||||.|:|.||||||:|.|.:||.|||:|.|:..:.    ||:.:|.|.|.|:|||||||:||||
  Fly  1117 VLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLAR 1181

  Fly  1282 AILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVE 1346
            ||||.|::||:||||||||||||||||.|||.||:.|||||:||||:|::||||::|:|||..||
  Fly  1182 AILRENRILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVE 1246

  Fly  1347 FDVPYLLLKKSQGHL-RQMVEATGGES-EALKKTASDSHKR 1385
            |..|:.||.:|...: ..||..||..| |.|.|.|.::|:|
  Fly  1247 FGSPFELLTQSWSKVFYGMVLQTGRSSFEHLLKLALEAHER 1287

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5789NP_001247286.1 CFTR_protein 9..1367 CDD:273530 571/1381 (41%)
ABC_membrane 214..441 CDD:294371 94/226 (42%)
ABCC_MRP_domain1 495..699 CDD:213217 119/203 (59%)
ABC_membrane 863..1088 CDD:294371 91/224 (41%)
ABCC_MRP_domain2 1135..1350 CDD:213211 133/220 (60%)
CG9270NP_995741.2 CFTR_protein 6..1257 CDD:273530 568/1371 (41%)
ABC_membrane 92..362 CDD:294371 103/351 (29%)
ABCC_MRP_domain1 412..611 CDD:213217 119/203 (59%)
ABC_membrane 718..981 CDD:294371 100/270 (37%)
ABCC_MRP_domain2 1029..1250 CDD:213211 133/220 (60%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 86 1.000 Domainoid score I2776
eggNOG 1 0.900 - - E2759_KOG0054
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 133 1.000 Inparanoid score I246
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 1 1.000 - - FOG0001028
OrthoInspector 1 1.000 - - otm14754
orthoMCL 1 0.900 - - OOG6_100026
Panther 1 1.100 - - P PTHR24223
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X771
109.870

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