DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5789 and Sur

DIOPT Version :9

Sequence 1:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster
Sequence 2:	NP_001334732.1	Gene:	Sur / 34350	FlyBaseID:	FBgn0028675	Length:	2223	Species:	Drosophila melanogaster

Alignment Length:	2101	Identity:	473/2101 - (22%)
Similarity:	752/2101 - (35%)	Gaps:	841/2101 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSH-------- 72
            |...|:..|.|..|||:.|.:..|..:||.|...||.:                |||
  Fly   226 ATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSA----------------RSHYDHFLYIY 274

  Fly    73 -RKKQKPHLRNALFRCF-----------------------LGPTIINGLICFIYIVIKTLIPAVL 113
             .||:|.:...:|:.|:                       :||..|..::.:|
  Fly   275 TEKKKKSNSSPSLWYCYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEYI------------ 327

  Fly   114 AQLLIQFQKTPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAG 178
            .||..|..:.|.....|      .:::.|..|:|.:             |:..|.:|..::||
  Fly   328 EQLYAQASEPPAKSPGN------EVANVLLSTSRIL-------------GTEFDEVFGTNIDK-- 371

  Fly   179 PLEPIQPPVEEVDHNATAVRSILDQTVEHMWNDMNSLG---AVLVLSTLFCCFLLHHVDLR-QRL 239
                              || |...|    |:|:.:.|   |.:||........|...... ..:
  Fly   372 ------------------VR-IYSST----WSDLLANGWCIAWIVLLAAITQGALSQASTHILNM 413

  Fly   240 MGARMRIACCSLIYRKTLRL-------SMKTAGQ-------------------TP---------- 268
            .|.|::.:...|||||:|.|       |..:|||                   ||
  Fly   414 TGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPN 478

  Fly   269 ----AGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPV 329
                .|.:.|.::.|...:...|:.:|:.|.:|.:..:..||:::|:||.|::|.:..::...|:
  Fly   479 ISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPL 543

  Fly   330 Q----TALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIR 390
            |    .|:||...|    ||..||.|:..:::.:.||:|||:.||::.|...:.||||.|:|
  Fly   544 QFFIGNAMSKNAEV----IAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELK--- 601

  Fly   391 YASYLRGFYLSTMVFTERSTLYITLAAAALMGQTI----TADFVFSAASYYNILQL-----VAAI 446
            |.:....|:....|.|..:|:.||...   :|..:    ..:|..:|:..::.|.|     |..:
  Fly   602 YLNKDATFWTLMAVLTHIATVLITFVT---LGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLL 663

  Fly   447 WYPLAVSFGAEALVSLRRIQDFL------------------------------------------ 469
            .:|:.|.....|.||.||::.||
  Fly   664 IFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTA 728

  Fly   470 --------------------------MLEGREERTQGLTHKRDQEGG------------------ 490
                                      :|:..||..:.::....||.|
  Fly   729 QAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYV 793

  Fly   491 ---------------------------------------DSRAVTIKDINASWDIEKPQKTLQSI 516
                                                   |..||:|.|...:|   :||..:..:
  Fly   794 AIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTW---QPQSQMPVV 855

  Fly   517 NLQ-----IEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQG--DLSYAAQEPWLFTGSV 574
            .|.     :.||:|..|:|..|:||:|:|..||.|:|::.|.:|...  .:||.:|:|||...::
  Fly   856 QLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTI 920

  Fly   575 RNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQ 639
            |.||||||.|..|||..|...|||..|.:.:|.||.:::||||.::|||||.||::|||:|..|.
  Fly   921 RENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSAN 985

  Fly   640 IYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQG 704
            :.:|||||:::|..||.|:|...|  |..|.:...|.||||.|:|.:.||:.::.:..||:...|
  Fly   986 VVIMDDPLASLDNEVGEHIFQHCI--REMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACG 1048

  Fly   705 TYQEL------INSDLDFARLLERPKEEEEGENSRNQTS-----------------PLSV----- 741
            :|.::      |.::.:....:.:.|.:...:|...:|:                 .:||
  Fly  1049 SYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDAN 1113

  Fly   742 ---------------------NSLESDDE-DIPF-IDGVKDGYQQLRKQSSSVHGSKSL------ 777
                                 |.:|.||: .:.: |.....|...|:::.||::||:.|
  Fly  1114 VACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPL 1178

  Fly   778 --DSTQLDD-------------------------------------------------------- 784
              |..|.||
  Fly  1179 PIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSS 1243

  Fly   785 ----NVDEDDLA--------------------------------------------EAQASGGIS 801
                :||..|||                                            ||:.|...|
  Fly  1244 YAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSS 1308

  Fly   802 --------------------------PRVWYEYFHAGSTLLSFS--------FMVFVMVM----- 827
                                      |:..:....|.:::||.|        |...::..
  Fly  1309 ESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKN 1373

  Fly   828 ------------------SQVVC-------SSSDFFANIWT----QQEH---------------- 847
                              :.:.|       |..:..||:.:    |::|
  Fly  1374 ETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRE 1438

  Fly   848 -----------QRSQGEATFSTFECMYI--YGALIIAVVIMTTF--------------------- 878
                       :|..|:.:...: .|||  .|..||.:..:|..
  Fly  1439 SMPLARLAIDTERKYGKISDDIY-LMYIRAAGLPIITIFFITALIWQCLRVYTDIWLQQWSNVHG 1502

  Fly   879 ----RGFL-------------FFK-------ICM---------------HASKVLHDRMFACILH 904
                :|.:             :|:       :|:               :|.:.|||::...|||
  Fly  1503 RVASKGHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILH 1567

  Fly   905 ATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVA 969
            .|:.||..||.|||:||||.||..||:.:.......:|..|:....:::...:.|.::...|.:.
  Fly  1568 KTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPIC 1632

  Fly   970 VVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQ----DVVAKEFDLLQDV 1030
            ....||.|.|...:::|:|:|....|||.||||.::.|:..||:...|    :::.|..    :.
  Fly  1633 GAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRL----EA 1693

  Fly  1031 HSSVWQLTMAVNTTLGLWLD----CVSCIFLTSVTFSFIIS------SETTYSGN---------- 1075
            ::..:.|....:..||:.||    |:  :|:.:||.....|      .|.|.|.:
  Fly  1694 NTIAYALLNTSHRWLGVSLDYLGGCI--VFVATVTALTAASVSCRRHYEATTSPSASASPSPFET 1756

  Fly  1076 ----------------VGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQY----------- 1113
                            |||||...:::...:.:.|:.:|:......||||:..|
  Fly  1757 YAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADAD 1821

  Fly  1114 --------TELEQEPALGE---------------------------------------------- 1124
                    .:|:.||:..|
  Fly  1822 ADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGG 1886

  Fly  1125 -------------------------------------------------KT--------PPQQ-- 1130
                                                             ||        ||||
  Fly  1887 DCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDD 1951

  Fly  1131 ------------------------WPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVG 1171
                                    ||.||.:.|.|:|.||:.....|:.||.|.|.||.::||.|
  Fly  1952 KDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICG 2016

  Fly  1172 RTGAGKSSLIGALFR-LAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFE 1235
            |||:|||||..:||. |....|.|:||.::...|..:.||||:||||||..||:||||.||||..
  Fly  2017 RTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHG 2081

  Fly  1236 RYTDAELWSALEDVELRKAIP-----GLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEA 1295
            .:.|.:||:.||..:|::.:.     |||.::.:.|.|.|.|.||||||||||||.:..||||||
  Fly  2082 YFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEA 2146

  Fly  1296 TANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGH 1360
            |:.:|..|::.:.:...:.|:..|::|:||||.|::|.||:||:|.|..||           .|:
  Fly  2147 TSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVE-----------DGN 2200

  Fly  1361 LRQMVEATGGESEA-LKKTAS 1380
            .|::.:..|..... |:|.||
  Fly  2201 PRELQQLEGSVFRGLLEKGAS 2221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	468/2085 (22%)
		ABC_membrane	214..441	CDD:294371	69/278 (25%)
		ABCC_MRP_domain1	495..699	CDD:213217	86/210 (41%)
		ABC_membrane	863..1088	CDD:294371	73/326 (22%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	103/220 (47%)
Sur	NP_001334732.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.160